This perspective article delineates the significant role of hypoxic pockets—localized,transient reductions in cerebral oxygenation—and their implications for stroke neuroprotection strategies.It posits that precondi...
Objective: To investigate the protective effect of nitrates postconditioning on myocardial ischemia-reperfusion injury and whether it plays a regulatory role in TNF-α in patients with STEMI during PCI. Methods: Patie...
supported by the Fujian Provincial Health Technology Project of China,No.2018-CX-16;Fujian Provincial Hospital Flint Fund Project,No.2020HSJJ17(both to SRL).
Bradykinin(BK)is an active component of the kallikrein-kinin system that has been shown to have cardioprotective and neuroprotective effects.We previously showed that BK postconditioning strongly protects rat hippocam...
supported by the National Natural Science Foundation of China grant (NSFC81970247)。
Background:Administration of propofol,an intravenous anesthetic with antioxidant property,immediately at the onset of post-ischemic reperfusion(propofol postconditioning,P-PostC) has been shown to confer cardioprotect...
National Natural Science Foundation of China to Chunyu Niu(No.81770492);Natural Science Foundation of Hebei Province to Zigang Zhao(No.H2020405012)。
To the Editor:Hemorrhagic shock is a critical pathological process characterized by microcirculation dysfunction and hypoperfusion,with severe consequences of cell damage and organ dysfunction.Intestinal barrier dysfu...
supported by grants from Foundation for Innovative Research Groups of the National Natural Science Foundation of China(81421062);National Natural Science Foundation of China(81470891);863 National High Technology Research and Development Program of China for Young Scientist(2015AA020923);Public Technology Research and Social Development Projects(2016C33145);China Postdoctoral Science Foundation(2017M610374)
Background: Ischemia reperfusion injury(IRI) causes postoperative complications and influences the outcome of the patients undergoing liver surgery and transplantation. Postconditioning(Post C) is a known manual condi...
Myocardial infarction resulting from coronary atherosclerosis is the leading cause of death in modern soci- ety. Reperfusion is an essential treatment to salvage ischemia myocardium from necrosis, while it also leads ...
supported by the Science and Technology Research Program of Jinhua Municipality(No.2014-3-052),China
Objective: To evaluate the clinical effect of postconditioning on patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Methods: Randomized contr...
supported by grants from the National Science Foundation of China(30740080);Dean fund of the General Hospital of Jinan Military Command(2011Q08)
BACKGROUND: Rapid and complete reperfusion has been widely adopted in the treatment of patients with acute myocardial infarction(AMI), but this process sometimes can cause severe reperfusion injury. This study aimed t...