This perspective article delineates the significant role of hypoxic pockets—localized,transient reductions in cerebral oxygenation—and their implications for stroke neuroprotection strategies.It posits that precondi...
Objective: To investigate the protective effect of nitrates postconditioning on myocardial ischemia-reperfusion injury and whether it plays a regulatory role in TNF-α in patients with STEMI during PCI. Methods: Patie...
supported by the Fujian Provincial Health Technology Project of China,No.2018-CX-16;Fujian Provincial Hospital Flint Fund Project,No.2020HSJJ17(both to SRL).
Bradykinin(BK)is an active component of the kallikrein-kinin system that has been shown to have cardioprotective and neuroprotective effects.We previously showed that BK postconditioning strongly protects rat hippocam...
supported by the National Natural Science Foundation of China grant (NSFC81970247)。
Background:Administration of propofol,an intravenous anesthetic with antioxidant property,immediately at the onset of post-ischemic reperfusion(propofol postconditioning,P-PostC) has been shown to confer cardioprotect...
National Natural Science Foundation of China to Chunyu Niu(No.81770492);Natural Science Foundation of Hebei Province to Zigang Zhao(No.H2020405012)。
To the Editor:Hemorrhagic shock is a critical pathological process characterized by microcirculation dysfunction and hypoperfusion,with severe consequences of cell damage and organ dysfunction.Intestinal barrier dysfu...
supported by grants from Foundation for Innovative Research Groups of the National Natural Science Foundation of China(81421062);National Natural Science Foundation of China(81470891);863 National High Technology Research and Development Program of China for Young Scientist(2015AA020923);Public Technology Research and Social Development Projects(2016C33145);China Postdoctoral Science Foundation(2017M610374)
Background: Ischemia reperfusion injury(IRI) causes postoperative complications and influences the outcome of the patients undergoing liver surgery and transplantation. Postconditioning(Post C) is a known manual condi...
Background: It is well documented that sevoflurane postconditioning (SP) has a significant myocardial protection effect. However, the mechanisms underlying SP are still unclear. In the present study, we investigate...
This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81100150 and 81170144), and the Natural Science Foundation of Shanxi Province (No. 2012011040-1 ).
Apoptosis is a crucial mode of cell death induced by ischemia and reperfusion, and ischemic postconditioning (PostC) has been reported to inhibit cell apoptosis. Inducible nitric oxide synthase (iNOS) has been con...
Myocardial infarction resulting from coronary atherosclerosis is the leading cause of death in modern soci- ety. Reperfusion is an essential treatment to salvage ischemia myocardium from necrosis, while it also leads ...
supported by the Science and Technology Research Program of Jinhua Municipality(No.2014-3-052),China
Objective: To evaluate the clinical effect of postconditioning on patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Methods: Randomized contr...