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作品数:146被引量:280H指数:9
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相关领域:医药卫生更多>>
相关作者:田中宏明曹明张奠湘张瑞泉李世晋更多>>
相关机构:京都大学大连理工大学中国科学院华南植物园清华大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金上海市浦江人才计划项目更多>>
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Shedding light on the retina to see healthy and pathological aging
《Neural Regeneration Research》2025年第12期3537-3538,共2页Marília Inês Móvio Maria Camila Almeida Sergio T.Ferreira Alexandre Hiroaki Kihara 
With the advances in medicine and technology,life expectancy has increased significantly in recent decades.While this is positive news,it also brings major challenges to public health systems.As people live longer,the...
关键词:DISEASES ALZHEIMER cases 
Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds
《Neural Regeneration Research》2025年第4期1009-1014,共6页Antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa 
supported by Telethon Italy award GGP15225(to RC and GM);Italian Ministry of Health award RF-2016-02362950(to RC and CZ);the CJD Foundation USA(to RC);the Associazione Italiana Encefalopatie da Prioni(AIEnP)(to RC).
PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other mammals.PrPSccan adopt different patho...
关键词:anti-prion drug anti-PrPC antibody antisense oligonucleotide NEURODEGENERATION pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor 
Shedding light on the effects of sodium-glucose cotransporter 2 inhibitors in the early stages of heart failure
《World Journal of Cardiology》2025年第3期96-100,共5页Luigi Falco Emilio Di Lorenzo Daniele Masarone 
Heart failure(HF),which falls outside of the historical macrovascular or microvascular categorizations of diabetes complications,has been overlooked for long time in diabetic patients,despite its increasing prevalence...
关键词:Heart failure Sodium-glucose cotransporter 2 Sodium-glucose cotransporter 2 inhibitors Diabetes complications Glycemic control 
Integrative single-cell and metagenomic analysis dissects SARS-CoV-2 shedding modes in human respiratory tract
《Biosafety and Health》2025年第1期5-16,共12页Xiangxing Jin Lili Ren Xianwen Ren Jianwei Wanag 
Science Fund for Creative Research Groups of the National Natural Science Foundation of China(82221004);the National Natural Science Foundation(81930063);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-12M-1-038);Changping Laboratory research fund.
It is crucial to understand how severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)sheds in human respiratory tract,but this question remains elusive due to technical limitations.In this study,we integrated pu...
关键词:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Viral shedding RNA-Seq Single-cell analysis 
Super-resolution microscopy:Shedding new light on blood cell imaging
《Journal of Innovative Optical Health Sciences》2025年第1期29-53,共25页Huan Deng Yan Ma Yu-Hui Zhang 
supported by the following grants:National Key R&D Program of China(Grant no.2022YFC3401100);National Natural Science Foundation of China(Grant nos.32271428,92054110,32201132 and 31600692).
Blood cells are the most integral part of the body,which are made up of erythrocytes,platelets and white blood cells.The examination of subcellular structures and proteins within blood cells at the nanoscale can provi...
关键词:Super-resolution imaging blood cells subcellular structure PROTEINS 
Enhancing RBD exposure and S1 shedding by an extremely conserved SARS-CoV-2 NTD epitope
《Signal Transduction and Targeted Therapy》2024年第9期3566-3568,共3页Qianhui Zhu Pan Liu Shuo Liu Can Yue Xiangxi Wang 
supported by Ministry of Science and Technology of China(CPL-1233 and SRPG22-003);National Key Research and Development Program(2018YFA0900801);CAS(YSBR-010);National Natural Science Foundation of China(NSFC)(32200138);the National Science Foundation Grants(12034006,32325004 and T2394482);supported by National Science Fund for Distinguished Young Scholar(No.32325004);the NSFS Innovative Research Group(No.81921005).
Dear Editor,Multiple waves of outbreaks of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have resulted in unprecedented public health and socioeconomic crises.After 4 years of primary as well as breakthro...
关键词:properties acute respiratory 
Shedding light on pancreatic metastasis of clear cell sarcoma:An exceptional journey
《World Journal of Clinical Cases》2024年第25期5657-5661,共5页Preeti Kumari Chaudhary Soochong Kim 
Supported by National Research Foundation of Korea,No.NRF-2022R1A2C1003638;The Basic Research Lab Program through the NRF of Korea Funded by The Ministry of Science and ICT,No.2022R1A4A1025557.
This editorial comments on the study by Liu et al investigating pancreatic metastasis of clear cell sarcoma(CCS)published in the World Journal of Clinical Cases.CCS is a rare and aggressive melanocytic tumor,that typi...
关键词:Clear cell sarcoma PANCREAS METASTASIS DIAGNOSIS Treatment 
Estimating the effective reproduction number of COVID-19 from population-wide wastewater data:An application in Kagawa,Japan
《Infectious Disease Modelling》2024年第3期645-656,共12页Yuta Okada Hiroshi Nishiura 
Y.O.received funding from the SECOM Science and Technology Foundation,The Kyoto University Foundation,and Fujiwara Memorial Foundation.H.N.received funding from Health and Labour Sciences Research Grants(grant numbers 20CA2024,21HB1002,21HA2016,and 23HA2005);the Japan Agency for Medical Research and Development(grant numbers JP23fk0108612 and JP23fk0108685);JSPS KAKENHI(grant numbers 21H03198 and 22K19670);the Environment Research and Technology Development Fund(grant number JPMEERF20S11804)of the Environmental Restoration and Conservation Agency of Japan,Kao Health Science Research;the Daikin GAP Fund of Kyoto University,the Japan Science and Technology Agency SICORP program(grant numbers JPMJSC20U3 and JPMJSC2105);the RISTEX program for Science,Technology,and Innovation Policy(grant number JPMJRS22B4)。
Although epidemiological surveillance of COVID-19 has been gradually downgraded globally,the transmission of COVID-19 continues.It is critical to quantify the transmission dynamics of COVID-19 using multiple datasets ...
关键词:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Wastewater-based epidemiology Shedding load distribution'Mathematical model 
Early diagnosis of pancreatic cancer: Shedding light on an unresolved challenge
《World Journal of Clinical Cases》2024年第14期2463-2465,共3页Cristian Lindner 
Diagnosing early-stage pancreatic cancer(PC)remains a clinical challenge.Hence,studying novel imaging aspects that could enhance the diagnostic accuracy of malignant pancreatic precursor lesions is imperative.This art...
关键词:Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Pancreatic ducts Cancer Early diagnosis 
Shedding light on gene therapy of Parkinson’s disease in non-human primates
《The Innovation》2024年第2期15-16,共2页Xunyi Yan Xin Jin 
Parkinson’s disease(PD)is a progressive neurodegeneration disease initially described by James Parkinson.It is typically diagnosed based on clinical features such as bradykinesia,resting tremor,rigidity,and,in later ...
关键词:CLINICAL RIGIDITY initially 
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