Oxygen electrocatalysis,exemplified by the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER),is central to energy storage and conversion technologies such as fuel cells,metal-air batteries,and water ele...
the Ministry of Science and Technology of China(Nos.2017YFA0204503,2016YFB0401100);the National Natural Science Foundation of China(Nos.21875259,51725304,51633006,61890943,91833306,51822308,21975263);the Strategic Priority Research Program(No.XDB12030300)of the Chinese Academy of Sciences and Beijing National Laboratory for Molecular Sciences(No.BNLMS-CXXM-202012)。
In this article,an acid-responsive luminescent material,1,4-di(quinoline-6-yl)buta-1,3-diyne(DQBD)is designed and synthesized.Upon different pH values,gradual changes of fluorescence colors for DQBD in both solution a...
This work was supported by grants from the National Natural Science Foundation of China(Grant Nos.81772974,81972882,and 81874297);the Bilateral Inter-Governmental S&T Cooperation Project from Ministry of Science and Technology of China(Grant No.2018YFE0114300);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University.We thank Dr.Scott McKercher(The Scripps Research Institute,La Jolla,CA,USA);Dr.Phillip Bryant(Childrens Hospital of Philadelphia,PA,USA);Dr.Cameron R.McKay(Nankai University School of Medicine,Tianjin,China)for revising the manuscript.
Objective:Angiogenesis plays a vital role in tumor growth and metastasis.Here,we aimed to find novel efficient antiangiogenic molecules targeting vascular endothelial growth factor A(VEGFA)at the transcriptional level...
supported by the National Natural Science Foundation of China (21390402, 21520102003, 21702150);the National Basic Research Program of China (2012CB725302);the CAS Interdisciplinary Innovation Team and the Hubei Province Natural Science Foundation of China (2017CFA010);China Postdoctoral Science Foundation (BX201600114, 2016M602340)
Selective C–H bond functionalization has been emerged as a versatile strategy for the construction of new chemical bonds. In the past decades, the directing group(DG)-assisted C–H bond activation has been developed ...
National Basic Research Program of China(Grant No.2012CB518000);Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120001110010)
CGRP receptor(CLR) is a B class GPCR that functions only when combined with RAMPs. CLR/RAMP1 has been regarded as a promising target for migraine treatment, as its antagonists have been proved to be effective recent...
supported by the National Natural Science Foundation of China(81325011);the National High Technology Research&Development Program of China(2012AA022703);the National Basic Research Program of China(2010CB732404);the Major Science&Technology Project of Suzhou(ZXY2012028)
Cancer is still one of the important diseases that threatens the health of people. Multidrug resistance(MDR) is the main factor that leads to the failure of cancer chemotherapy. Thus, MDR diagnosis could facilitate th...
supported by the National Natural Science Foundation of China(51173199,51211140346,61405209);the National Basic Research Program of China(2014CB643501,2010DFA52310);the Shandong Provincial Natural Science Foundation(ZR2011BZ007);the Qingdao Municipal Science and Technology Program(11-2-4-22-hz)
A new star-shaped small molecule named TCNR3TTPA,with a triphenylamine(TPA)unit as the central building block and2-(1,1-dicyanomethylene)-3-octyl rhodanine(CNR)as the end-capped group,has been designed and synthesized...
financially supported by the National Basic Research Program of China(2013CB933501);the National Natural Science Foundation of China;supported by a General Financial Grant(2013M530135)from the China Postdoctoral Science Foundation
Organic electron acceptor materials play an important role in organic electronics.Recently,many organic electron acceptors have been developed,in which aromatic fused-imides have proved to be a promising family of exc...
Supported by the National Natural Science Foundation of China(No.81360479), the Ministry of Science and Technology of China(No.2012CB722601) and the Science and Technology Department of Guizhou Province, China(Nos.QKHZYZ[2011]5085, QKHRZ[2011]33).
A series of derivatives of tetrandrine and fangchinoline was designed and synthesized to find more active anti-cancer compounds. Their anti-cancer activities were tested against human hcpatocellular carcinoma BEL-7402...
The project was supported by National Natural Science Foundation of China (81321092) and by a grant from the National Basic Research Program of China (2013CB932503).
Aim: To investigate the effects of G226, a novel epipolythiodioxopiperazine derivative, on human breast cancer cells in vitro, and to explore its anticancer mechanisms. Methods: A panel of human breast cancer cell l...