DERIVATIVE

作品数:1328被引量:1709H指数:14
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相关领域:理学更多>>
相关作者:梁宇学王超张东辉韩立杨鹰更多>>
相关机构:北京大学中南大学吉林大学沈阳药科大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>
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Two-dimensional MOF/MOF derivative arrays on nickel foam as efficient bifunctional coupled oxygen electrodes被引量:4
《Chinese Journal of Catalysis》2020年第11期1754-1760,共7页Kai Huang Shuai Guo Ruyue Wang Sen Lin Naveed Hussain Hehe Wei Bohan Deng Yuanzheng Long Ming Lei Haolin Tang Hui Wu 
国家自然科学基金(51902027,61874013,51976143,61874014,61674019,61974011);国家973计划基金(2015CB932500);中央高校基本科研业务费专项资金(2019RC20);信息光子学与光通信国家重点实验室(北京邮电大学)开放课题.
Oxygen electrocatalysis,exemplified by the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER),is central to energy storage and conversion technologies such as fuel cells,metal-air batteries,and water ele...
关键词:2DMOFs DERIVATIVE Coupled arrays Binder-free Oxygen electrode 
A new fluorescent quinoline derivative toward the acid-responsivity in both solution and solid states
《Chinese Chemical Letters》2020年第11期2909-2912,共4页Pu Wang Dan Liu Yongshuai Wang Pan Zhang Panpan Yu Mincan Wang Yonggang Zhen Huanli Dong Wenping Hu 
the Ministry of Science and Technology of China(Nos.2017YFA0204503,2016YFB0401100);the National Natural Science Foundation of China(Nos.21875259,51725304,51633006,61890943,91833306,51822308,21975263);the Strategic Priority Research Program(No.XDB12030300)of the Chinese Academy of Sciences and Beijing National Laboratory for Molecular Sciences(No.BNLMS-CXXM-202012)。
In this article,an acid-responsive luminescent material,1,4-di(quinoline-6-yl)buta-1,3-diyne(DQBD)is designed and synthesized.Upon different pH values,gradual changes of fluorescence colors for DQBD in both solution a...
关键词:Quinoline derivative STIMULI-RESPONSIVE Protonation effect Fluorescence switch pH sensor 
An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway被引量:6
《Cancer Biology & Medicine》2020年第3期693-706,共14页Xiaotong Zhang Gengyi Zou Xiyang Li Lun Wang Tianyu Xie Jin Zhao Longlong Wang Shunchang Jiao Rong Xiang Haoyu Ye Yi Shi 
This work was supported by grants from the National Natural Science Foundation of China(Grant Nos.81772974,81972882,and 81874297);the Bilateral Inter-Governmental S&T Cooperation Project from Ministry of Science and Technology of China(Grant No.2018YFE0114300);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University.We thank Dr.Scott McKercher(The Scripps Research Institute,La Jolla,CA,USA);Dr.Phillip Bryant(Childrens Hospital of Philadelphia,PA,USA);Dr.Cameron R.McKay(Nankai University School of Medicine,Tianjin,China)for revising the manuscript.
Objective:Angiogenesis plays a vital role in tumor growth and metastasis.Here,we aimed to find novel efficient antiangiogenic molecules targeting vascular endothelial growth factor A(VEGFA)at the transcriptional level...
关键词:ISOFLAVONE MTA2 SERRS tumor angiogenesis VEGFA 
Oxidation-induced ortho-selective C–H bond functionalization of 2-naphthylamine derivative被引量:1
《Science China Chemistry》2018年第10期1274-1277,共4页Dongchao Zhang Zhiliang Huang Aiwen Lei 
supported by the National Natural Science Foundation of China (21390402, 21520102003, 21702150);the National Basic Research Program of China (2012CB725302);the CAS Interdisciplinary Innovation Team and the Hubei Province Natural Science Foundation of China (2017CFA010);China Postdoctoral Science Foundation (BX201600114, 2016M602340)
Selective C–H bond functionalization has been emerged as a versatile strategy for the construction of new chemical bonds. In the past decades, the directing group(DG)-assisted C–H bond activation has been developed ...
关键词:oxidation-induced C-H bond functionalization ortho-selectivity 
Design,synthesis and bioevaluation of isoflavone derivative as a novel CLR/RAMP1 antagonist
《Journal of Chinese Pharmaceutical Sciences》2017年第7期504-511,共8页王俊杰 王超 吕鹏 牛彦 李宏月 黄文慧 李灿 徐凤荣 梁磊 徐萍 
National Basic Research Program of China(Grant No.2012CB518000);Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120001110010)
CGRP receptor(CLR) is a B class GPCR that functions only when combined with RAMPs. CLR/RAMP1 has been regarded as a promising target for migraine treatment, as its antagonists have been proved to be effective recent...
关键词:ISOFLAVONE CLR/RAMP1 antagonist Research 
Spectroscopic and electrochemical studies on molecular recognition of tetrathiafulvalene derivative with P-glycoprotein and drug-resistant leukemia cells
《Science China Chemistry》2015年第7期1193-1199,共7页Yuanyuan Zhang Changyu Wu Hui Jiang Jinglin Zuo Xuemei Wang 
supported by the National Natural Science Foundation of China(81325011);the National High Technology Research&Development Program of China(2012AA022703);the National Basic Research Program of China(2010CB732404);the Major Science&Technology Project of Suzhou(ZXY2012028)
Cancer is still one of the important diseases that threatens the health of people. Multidrug resistance(MDR) is the main factor that leads to the failure of cancer chemotherapy. Thus, MDR diagnosis could facilitate th...
关键词:tetrathiafulvalene derivative leukemia cell P-GLYCOPROTEIN electrochemical detection Fourier transform infraredspectroscopy 
High open-circuit voltage solution-processed organic solar cells based on a star-shaped small molecule end-capped with a new rhodanine derivative
《Science China Chemistry》2015年第2期357-363,共7页Yuanhang Zhou Weichao Chen Zhengkun Du Dangqiang Zhu Dan Ouyang Liangliang Han Renqiang Yang 
supported by the National Natural Science Foundation of China(51173199,51211140346,61405209);the National Basic Research Program of China(2014CB643501,2010DFA52310);the Shandong Provincial Natural Science Foundation(ZR2011BZ007);the Qingdao Municipal Science and Technology Program(11-2-4-22-hz)
A new star-shaped small molecule named TCNR3TTPA,with a triphenylamine(TPA)unit as the central building block and2-(1,1-dicyanomethylene)-3-octyl rhodanine(CNR)as the end-capped group,has been designed and synthesized...
关键词:organic solar cells open-circuit voltage triphenylamine rhodanine derivative 
Synthesis, crystal structure, and application of an acenaphtho[1,2-k] fluoranthene diimide derivative被引量:2
《Science China Chemistry》2015年第2期364-369,共6页Lin Ding Chiyuan Yang Zhongmin Su Jian Pei 
financially supported by the National Basic Research Program of China(2013CB933501);the National Natural Science Foundation of China;supported by a General Financial Grant(2013M530135)from the China Postdoctoral Science Foundation
Organic electron acceptor materials play an important role in organic electronics.Recently,many organic electron acceptors have been developed,in which aromatic fused-imides have proved to be a promising family of exc...
关键词:acenaphtho fluoranthene diimide lithium-halogen exchange Diels-Alder reaction electron acceptor solar cell 
Syntheses and Anti-cancer Activities of Derivatives of Tetrandrine and Fangchinoline被引量:3
《Chemical Research in Chinese Universities》2014年第6期937-940,共4页LIU Yazhou HUANG Lan SUN Qianyun ZHANG Maosheng LI Tianlei LIANG Guangyi PAN Weidong 
Supported by the National Natural Science Foundation of China(No.81360479), the Ministry of Science and Technology of China(No.2012CB722601) and the Science and Technology Department of Guizhou Province, China(Nos.QKHZYZ[2011]5085, QKHRZ[2011]33).
A series of derivatives of tetrandrine and fangchinoline was designed and synthesized to find more active anti-cancer compounds. Their anti-cancer activities were tested against human hcpatocellular carcinoma BEL-7402...
关键词:TETRANDRINE FANGCHINOLINE DERIVATIVE CYTOTOXICITY 
G226, a novel epipolythiodioxopiperazine derivative, induces autophagy and caspase-dependent apoptosis in human breast cancer cells in vitro被引量:5
《Acta Pharmacologica Sinica》2014年第8期1055-1064,共10页Peng-xing HE Yong-sheng CHE Qiao-jun HE Yi CHEN Jian DING 
The project was supported by National Natural Science Foundation of China (81321092) and by a grant from the National Basic Research Program of China (2013CB932503).
Aim: To investigate the effects of G226, a novel epipolythiodioxopiperazine derivative, on human breast cancer cells in vitro, and to explore its anticancer mechanisms. Methods: A panel of human breast cancer cell l...
关键词:breast cancer epipolythiodioxopiperazine dideoxyverticillin apoptosis AUTOPHAGY LC3 P62 CASPASE-8 anticancer drug 
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