INTERLEUKIN-11

作品数：11被引量：20H指数：3
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相关领域：医药卫生更多>>
相关机构：天津医科大学苏州大学更多>>
相关期刊：《Genes & Diseases》《Journal of Biomedical Research》《World Journal of Clinical Cases》《Cancer Communications》更多>>
相关基金：国家自然科学基金中国博士后科学基金天津市自然科学基金更多>>
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Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo
《Journal of Environmental Sciences》2023年第4期772-783,共12页Jixuan Ma Yujia Xie Yiju Xu Pei Gu Yingdie Zhang Lieyang Fan Yun Zhou Haijiao Wang Ting Zhou Jintong He Dongming Wang Weihong Chen 
supported by the National Natural Science Foundation of China (Nos. 81803205 and 81872593);the China Postdoctoral Science Foundation (No. 2019T120665);the Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (No. OHIC_(2)020G01);the Fundamental Research Funds for the Central Universities (No. 2020kfy XJJS005);the Open Projects Program of Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment (No. 2017B030314152)。
Environmental exposure to crystalline silica particles can lead to silicosis, which is one of the most serious pulmonary interstitial fibrosis around the world. Unfortunately, the exact mechanism on silicosis is uncle...
关键词：Silica particles INFLAMMATION FIBROSIS INTERLEUKIN-11 SILICOSIS 
Coding variants of the interleukin-11 receptor with reduced protein maturation show protease-dependent trans-signaling and transduce normal STAT3 signaling
《Genes & Diseases》2023年第2期373-376,共4页Birte Kespohl Roland Hartig Yvonne Garbers Juliane Lokau Christoph Garbers 
supported by a grant from the Deutsche Forschungsgemeinschaft(No.125440785,SFB877,A10).
Interleukin-11(IL-11)is a member of the IL-6 family of cytokines.1 IL-11 activates its target cells via binding to the IL-11 receptor(IL-11R),which also exists in soluble forms generated by proteolytic cleavage(sIL-11...
关键词：STAT3 PI3K GP130 
Mucin 1 and interleukin-11 protein expression and inflammatory reactions in the intestinal mucosa of necrotizing enterocolitis children after surgery被引量：1
《World Journal of Clinical Cases》2021年第25期7372-7380,共9页Hong-Xia Pan Chang-Song Zhang Chia-Hui Lin Min-Min Chen Xiao-Zhong Zhang Nong Yu 
Suzhou Science and Technology Program,No.SLT202005;Suzhou Municipal Commission of Health and Family Planning,No.LCZX202031;Suzhou New District Science and Technology Plan,No.2019Z009;Independent Innovation Project of National High Tech Development Zone Hospital,No.SGY2018C03.
BACKGROUND Necrotizing enterocolitis(NEC)of the newborn is a frequently occurring clinical disease in infants.The mortality rate of NEC in premature infants is as high as 50%,and the morbidity rate is on the rise.NEC ...
关键词：Neonatal necrotizing enterocolitis Mucin 1 INTERLEUKIN-11 INFLAMMATION Intestinal mucosa Expression 
miR-495 andmiR-5688 are down-regulated in non-small cell lung cancer under hypoxia to maintain interleukin-11 expression被引量：3
《Cancer Communications》2020年第9期435-452,共18页Meng Zhao Jiao Chang Ran Liu Yahui Liu Jin Qi Yanhui Wang Xinwei Zhang Lu Qiao Yu Jin Haohua An Li Ren 
supported by the National Natural Science Foundation of China(No.81602026);the Natural Science Foundation of Tianjin(No.18JCQNJC81600 and 18JCZDJC32600).
Background:Hypoxia is a hallmark of cancer and is associated with poor prognosis.However,the molecular mechanism by which hypoxia promotes tumor progression remains unclear.MicroRNAs dysregulation has been shown to pl...
关键词：HYPOXIA INTERLEUKIN-11 miR-495 miR-5688 non-small cell lung cancer PicTAR Targetscan 
Near-infrared fluorescent labeled CGRRAGGSC peptides for optical imaging of IL-11Rα in athymic mice bearing tumor xenografts被引量：1
《The Journal of Biomedical Research》2019年第6期391-397,共7页Tiannv Li Jin Sun Yao Hu Min Yang Haibin Shi Lijun Tang 
Supported by National Natural Science Foundation of China (No.81202032);Key University Science Research Project of Jiangsu Province (No. 16KJB320004);Jiangsu Provincial Health and Family Planning Commission Foundation (No.Z201502);Jiangsu Provincial Health and Family Planning Research Projects (No.H2018029);Key Laboratory of Nuclear Medicine of the Ministry of Health, Jiangsu Provincial Key Laboratory of Molecular Nuclear Medicine (No.KF201501)
The interleukin-11(IL-11)and the IL-11 receptorα-subunit(IL-11Rα)have been demonstrated to regulate the invasion and proliferation of tumor cells.Our study intends to evaluate a noninvasive imaging of IL-11Rαexpres...
关键词：interleukin-11 receptor molecular imaging NEAR-INFRARED breast tumors 
Research progress of interleukin-11 in tumor
《TMR Cancer》2018年第1期2-7,共6页Chen Huang Ya-Hui Liu Li Ren 
Interleukin-11 （IL-11） is a cytokine of IL-6 family that mediates signal transduction through a common signal transduction molecule glycoprotein 130gp130. JAK/STAT, Ras/Erk and PI3K-mediated pathways are involved in...
关键词：IL-11 Cancer progress Signaling pathways 
Unusual early-stage pancreatic sarcomatoid carcinoma被引量：3
《World Journal of Gastroenterology》2013年第43期7820-7824,共5页Chuan-Li Ren Ping Jin Chong-Xu Han Qin Xiao Dao-Rong Wang Lin Shi Da-Xin Wang Hui Chen 
Supported by China Postdoctoral Science Foundation,No.2013M541699;Social Development of Jiangsu Province,No.BE2012705;the Foundation of Northern Jiangsu People’s Hospital,No.Yzucms201213
Sarcomatoid carcinoma of the pancreas(SCP)is a very rare pathological type of carcinoma that usually has a poor prognosis.Its pathogenesis has not been elucidated.We herein report a case of an early-stage SCP involvin...
关键词：SARCOMATOID carcinoma of the PANCREAS Transforming growth factorβ1 Epithelial-to MESENCHYMAL transition INTERLEUKIN-11 VIMENTIN 
An effective and simple expansion system for megakaryocyte progenitor cells using a combination of heparin with thrombopoietin and interleukin-11被引量：1
《中国生物学文摘》2006年第5期26-26,共1页Feng Y Zhang L Xiao ZJ Li B Liu B Fan CG Yuan XF Han ZC 
关键词：巨核细胞 肝磷脂 输血疗法 血小板减少症 放射线疗法 化学疗法 
Effect of recombinant human interleukin-11 on expressions of interleukin-11 receptorα-chain and glycoprotein 130 in intestinal epithelium cell line-6 after neutron irradiation被引量：4
《World Journal of Gastroenterology》2006年第19期3055-3059,共5页Rui-Juan Wang Rui-Yun Peng Kai-Fei Fu Ya-Bing Gao Rui-Gang Han Wen-Hua Hu Qing-Liang Luo Jun-Jie Ma 
Supported by National Natural Science Foundation of China,No. 30370438
AIM： To explore the effect of recombinant human interleukin-11 （rhIL-11） on the expressions of interleukin-11 receptor α-chain （IL-11Rα） and an additional signal transducer glycoprotein 130 （gp130） in intesti...
关键词：Neutron IEC-6 INTERLEUKIN-11 IL-11Rα GP130 
Expression of Interleukin-11 and Interleukin-11 receptor a in human colorectal adenocarcinoma; Immunohistochemical analyses and correlation with clinicopathological factors被引量：7
《World Journal of Gastroenterology》2006年第2期317-321,共5页Kazuyuki Yamazumi Toshiyuki Nakayama Takafumi Kusaba Chun Yang Wen Ayumi Yoshizaki Yuichi Yakata Takeshi Nagayasu Ichiro Sekine 
AIM： There is strong evidence that interleukin-11 （IL-11） is involved in the regulation of tumor progression, cellular growth and differentiation. Recently, interleukin-11 receptor （IL-11R） has been detected on s...
关键词：IL-11  IL-11 receptor α Colorectal cancer 
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