OSTEOCHONDRAL

作品数：66被引量：256H指数：9
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相关领域：医药卫生更多>>
相关作者：陶金刚徐海斌黄媛霞更多>>
相关机构：第三军医大学西南医院新乡医学院第一附属医院青岛市市立医院更多>>
相关期刊：《Chinese Journal of Traumatology》《Science China(Life Sciences)》《Regenerative Biomaterials》《Nano-Micro Letters》更多>>
相关基金：国家自然科学基金中国博士后科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair
《Bioactive Materials》2024年第10期306-317,共12页Rachel H.Koh Junhee Kim Jeong-Uk Kim Seunghyun L.Kim Arun Kumar Rajendran Seunghun SLee Heesoo Lee Joo Hyun Kim Ji Hoon Jeong Yongsung Hwang Jong Woo Bae Nathaniel S.Hwang 
supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(NRF-2021K1A3A1A57086407,NRF-2021R1A2C2008821,NRF-2022R1I1A1A01071991);Arun Kumar Rajendran was supported by the National Research Foundation of Korea(NRF)grant Brain Pool program funded by the Ministry of Science and ICT through the National Research Foundation of Korea(2020H1D3A1A04081286);The Institute of Engineering Research at Seoul National University provided research facilities,and additional support came from the SNU Engineering-Medicine Collaboration grant.
Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage interface.Multilayered or gradient scaffolds,often in co...
关键词：BIOCERAMIC Whitlockite Bilayer scaffold Chondrocyte hypertrophy Osteochondral defect repair 
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration
《Bioactive Materials》2024年第8期305-320,共16页Cuijun Deng Chen Qin Zhenguang Li Laiya Lu Yifan Tong Jiaqi Yuan Feng Yin Yu Cheng Chengtie Wu 
The National Key Research and Development Program of China(2023YFB3813000);the National Natural Science Foundation of China(32271441,82102196,32225028);the Natural Science Foundation of Shanghai(21DZ1205600,22ZR1462800);Shanghai Municipal Education Commission Innovative Program(2023ZKZD27);State Key Laboratory of Molecular Engineering of Polymers(Fudan University,K2021-12).
Osteochondral regeneration involves the highly challenging and complex reconstruction of cartilage and subchondral bone.Silicon(Si)ions play a crucial role in bone development.Current research on Si ions mainly focuse...
关键词：DIATOMITE Si release Hierarchical scaffolds 3D printing Osteochondral regeneration 
Enhanced osteochondral regeneration with a 3D-Printed biomimetic scaffold featuring a calcified interfacial layer
《Bioactive Materials》2024年第6期317-329,共13页Di Wu Kaiwen Zheng Wenjing Yin Bin Hu Mingzhao Yu Qingxiao Yu Xiaojuan Wei Jue Deng Changqing Zhang 
supported by the National Natural Science Foundation of China(Grant No.82202690);the Shanghai Pujiang Program(2022PJD051);the China Postdoctoral Science Foundation(2022M712121);the Basic Science Program of Shanghai Sixth People’s Hospital(Grant No.ynqn202203).
The integrative regeneration of both articular cartilage and subchondral bone remains an unmet clinical need due to the difficulties of mimicking spatial complexity in native osteochondral tissues for artificial impla...
关键词：3D-printed scaffold Calcified interfacial layer CAV-1 Osteochondral regeneration Tasquinimod 
Integrating coaxial electrospinning and 3D printing technologies for the development of biphasic porous scaffolds enabling spatiotemporal control in tumor ablation and osteochondral regeneration
《Bioactive Materials》2024年第4期338-353,共16页Wenbao He Chunlin Li Shitong Zhao Zhendong Li Jing Wu Junjun Li Haichao Zhou Yunfeng Yang Yong Xu Huitang Xia 
supported by the National Natural Science Foundation of China(82302395 and 82001979);Natural Science Foundation of Shanghai(22YF1437400);Young Elite Scientists Sponsorship Program by CAST(2023QNRC001);Shandong Provincial Natural Science Foundation(Major Basic Research Program,ZR2019ZD38);Taishan Scholar Program of Shandong Province(To Huitang Xia,202211333);Natural Science Foundation of Shandong Province(ZR2020MH381);Academic Promotion Program of Shandong First Medical University(2019LJ005);Shandong First Medical University Culture Foundation(202201-09);Social Science Planning and Research Project of Shandong Province(21CTQJ08).
The osteochondral defects(OCDs)resulting from the treatment of giant cell tumors of bone(GCTB)often present two challenges for clinicians:tumor residue leading to local recurrence and non-healing of OCDs.Therefore,thi...
关键词：Spatiotemporal control Giant cell tumors of bone Shell-core structure Double-layered scaffold Osteochondral regeneration 
Full-thickness osteochondral defect repair using a biodegradable bilayered scaffold of porous zinc and chondroitin sulfate hydrogel被引量：4
《Bioactive Materials》2024年第2期400-414,共15页Fan Yang Yageng Li Lei Wang Haodong Che Xin Zhang Holger Jahr Luning Wang Dong Jiang Hongjie Huang Jianquan Wang 
supported by grants from the National Natural Science Foundation of China(grant numbers:82072403,82072428,82272571,82267020,82372418,52201294);Beijing Natural Science Foundation Haidian Original Innovation Joint Fund Frontier Project(L212052);Beijing Natural Science Foundation(L212014);Prosperos project,funded by the Interreg VA Flanders-The Netherlands program,CCI Grant No.2014TC16RFCB04;the Interdisciplinary Centre for Clinical Research(IZKF)of the Faculty of Medicine of the RWTH Aachen University(OC1-1).
The regeneration of osteochondral tissue necessitates the re-establishment of a gradient owing to the unique characteristics and healing potential of the chondral and osseous phases.As the self-healing capacity of hya...
关键词：Chondroitin sulfate hydrogel Additive manufacturing Porous Zn scaffold Osteochondral regeneration 
In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units被引量：9
《Bioactive Materials》2023年第9期200-215,共16页Zhen Yang Bin Wang Wei Liu Xiaoke Li Kaini Liang Zejun Fan Jiao Jiao Li Yudi Niu Zihao He Hui Li Du Wang Jianjing Lin Yanan Du Jianhao Lin Dan Xing 
funded by grants from Beijing Natural Science Foundation(7212118,L222087);Natural Science Foundation of China(81973606,82272538).
The regeneration of hierarchical osteochondral units is challenging due to difficulties in inducing spatial,directional and controllable differentiation of mesenchymal stem cells(MSCs)into cartilage and bone compartme...
关键词：Mesenchymal stem cells SELF-ASSEMBLY Microcryogels Osteochondral regeneration Organoid 
Engineering the viscoelasticity of gelatin methacryloyl(GelMA)hydrogels via small“dynamic bridges”to regulate BMSC behaviors for osteochondral regeneration被引量：5
《Bioactive Materials》2023年第7期445-459,共15页Changjiang Liu Qifan Yu Zhangqin Yuan Qianping Guo Xiting Liao Feng Han Tao Feng Guoping Liu Runze Zhao Zhuang Zhu Haijiao Mao Caihong Zhu Bin Li 
This work was supported by National Natural Science Foundation of China(81871805,81925027 and 32130059);Jiangsu Provincial Clinical Orthopedic Center,Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology,the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
The dynamic extracellular matrix(ECM)constantly affects the behaviors of cells.To mimic the dynamics of ECM with controllable stiffness and energy dissipation,this study proposes a strategy in which a small molecule,3...
关键词：Viscoelastic hydrogels Dynamic bonds GelMA Dissipation Osteochondral regeneration 
Bone/cartilage organoid on-chip:Construction strategy and application被引量：10
《Bioactive Materials》2023年第7期29-41,共13页Yan Hu Hao Zhang Sicheng Wang Liehu Cao Fengjin Zhou Yingying Jing Jiacan Su 
This work was supported by grants from National Natural Science Foundation of China(No.82230071,92249303 and 82172098 to J.Su);Shanghai Committee of Science and Technology(Laboratory Animal Research Project to J.Su);Shanghai Baoshan District Medical Health Project(No.21-E-14 to L.Cao);China Postdoctoral Science Foundation(No.2022M722033 to Y.Hu).
The necessity of disease models for bone/cartilage related disorders is well-recognized,but the barrier between ex-vivo cell culture,animal models and the real human body has been pending for decades.The organoid-on-a...
关键词：Organoid On-chip platform Osteochondral unit Ex-vivo disease model 
Recent development in multizonal scaffolds for osteochondral regeneration被引量：6
《Bioactive Materials》2023年第7期122-159,共38页Le Yu Sacha Cavelier Brett Hannon Mei Wei 
Osteochondral(OC)repair is an extremely challenging topic due to the complex biphasic structure and poor intrinsic regenerative capability of natural osteochondral tissue.In contrast to the current surgical approaches...
关键词：Multizonal scaffolds Osteochondral regeneration FABRICATION CELLS Growth factors 
Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration被引量：3
《Bioactive Materials》2023年第2期221-242,共22页Zhicheng Cao Hongmei Wang Jialin Chen Yanan Zhang Qingyun Mo Po Zhang Mingyue Wang Haoyang Liu Xueyang Bao Yuzhi Sun Wei Zhang Qingqiang Yao 
supported by the National Natural Science Foundation of China(81901903,5171101275,81771985,81972042,82072400);the Natural Science Foundation of Jiangsu Province(BK20190356,BK20190354,BK20200001,BE2019736,BE2019679);the Zhishan Scholars Programs of Southeast University and the Postgraduate Research and Innovation Project of Jiangsu Province(SJCX 21_0637).
Osteochondral defects(OCD)cannot be efficiently repaired due to the unique physical architecture and the pathological microenvironment including enhanced oxidative stress and inflammation.Conventional strategies,such ...
关键词：Osteochondral regeneration Metal-organic framework Nanozyme INFLAMMATION ROS SILK 
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