supported in part by the National Key Research and Development Program of China(2022YFC2303100);the National Natural Science Foundation of China(32030002,22193070);the Shanghai Post-Doctoral Excellence Program(2022718)。
Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM)proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members.Many of these proteins are in...
financial support from the schoollevel research projects of Yancheng Institute of Technology(No.xjr2020044);the National Natural Science Foundation of China(Nos.22101152,22271123 and 21971090)。
Catalytic C–H activation-initiated annulation reactions have emerged as a versatile strategy for the efficient construction of diverse ring structural units and complex cyclic molecules in synthetic chemistry.Herein,...
We gratefully acknowledge the Provincial Planning Project of the Zhejiang Provincial Science and Technology Department(No.LGF19B060005)for financial support.
A novel and green route have been developed for the electrochemical synthesis of 3-halogenated spiro[4.5]trienones based on dearomative spirocyclization of alkynes with NaX(Br,I)as the halogen source.This transformati...
supported by CAMS Innovation Fund for Medical Sciences(No.2021-12M-1-030);the Natural Science Foundation of Beijing Municipality(No.7202131);Chinese Pharmaceutical Association-Yiling Pharmaceutical Innovation Fund for Biomedicine(No.GL-1-B04-20190397)。
We found compound 12N-p-trifluoromethylbenzenesulfonyl matrinane(1)was a potent anti-diabetic agent.Thirty-five tricyclic matrinic derivatives were synthesized and determined for their stimulatory effects on glucose c...
support from the Natural Science Foundation of China and Shandong Province(No.21971149,92156007,ZR2019ZD45,and ZR2020KB005);the Fundamental Research Funds of Shandong University.
A new rhodium(I)–BINAP-catalyzed enantioselective desymmetric Pauson–Khand (PK) reaction of prochiral 1,6-enynes with CO has been developed. Diverse tricyclic 6,5,5-fused bowl type polycycles withthree continuous ch...
This work was supported by the Personalized Medicines-Molecular Signature-based"Drug Discovery and Development,"Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDA12020369);the National Natural Science Foundation of China(NSFC)(grant No.81903882);the National Science and Technology Major Project"New Drug Creation and Manufacturing Program",China(grant No.2018ZX09711002-014-001).
Rheumatoid arthritis(RA)is characterized by joint leukocyte infiltration,synovial inflammation and bone damage result from osteoclastogenesis.Bruton’s tyrosine kinase(BTK)is a key regulator of B cell receptor(BCR)and...
Tricyclic and tetracyclic terpanes are important constituents of crude oil and source rock extracts.However,they have not been reported in the Offshore Niger Delta Basin,Nigeria.Thus,the present study investigated the...
Terpenoids have drawn much attention to scientists in synthesizing high-performance bio-jet fuels due to their ring structures,which feature potential high densities.Here,a facile biphasic catalytic process has been d...
supported by the National Natural Science Foundation of China(No.21502011);the Fundamental Research Funds for the Central Universities;the Chongqing Science&Technology Commission Project(No.cstc2016jcyjA0168)。
Efficient synthetic routs for the direct and rapid construction of[5-6-6]ABC tricyclic systems of daphmanidin A-type and calyciphylline A-type alkaloids have been successfully developed.For the daphmanidin A-type,the ...
Let G be a graph and A=(aij)n×n be the adjacency matrix of G, the eigenvalues of A are said to be the eigenvalues of the graph G, and to form the spectrum of this graph. The numbers of positive, negative and zero eig...