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Systemically intravenous siRNA delivery into brain with a targeting and efficient polypeptide carrier and its evaluation on anti-glioma efficacy: 《Chinese Chemical Letters》2025年第3期396-401,共6页Liqing Chen Zheming Zhang Yanhong Liu Chenfei Liu Congcong Xiao Liming Gong Mingji Jin Zhonggao Gao Wei Huang; supported by CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-026,China).; Gliomas are the most common intracranial tumors with poor survival and high mortality.Furthermore,the clinical efficacy of current drugs is still not ideal;despite the development of several therapeutic drugs over the...; 关键词：15-Amino-acid peptide GLIOMA Brain targeting Gene silencing Transvascular delivery

Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles for ovalbumin delivery: 《Chinese Chemical Letters》2022年第8期4084-4088,共5页Yingying Song Chang-Ming Dong; the financial support of the National Natural Science Foundation of China(Nos.22075176 and21774074)。; Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles were disclosed for ovalbumin(OVA)delivery system.The mannose-coated polypeptide nanoparticles can induce st...; 关键词：Polypeptide nanoparticles Sugar targeting Immune adjuvant Ovalbumin delivery system

Controlled synthesis of polypeptides被引量：4: 《Chinese Chemical Letters》2020年第12期3001-3014,共14页Yang Liu Di Li Jianxun Ding Xuesi Chen; the financial support from the National Natural Science Foundation of China(Nos.51973216,51873207,51803006,51833010,51673190 and 51520105004);the Science and Technology Development Program of Jilin Province(No.20190201068JC);the National Key Research and Development Program of China(No.2016YFC1100701);the Youth Talents Promotion Project of Jilin Province(No.181909);the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2019005)。; Polypeptides are one kind of promising biodegradable and biocompatible biomedical polymers with the structural units of various a-amino acids.Polypeptides were first polymerized by the ring-opening polymerization(ROP)...; 关键词：α-Amino acid N-carboxyanhydride Ring-opening polymerization Controlled synthesis POLYPEPTIDE Biomedical application

Discovery of a novel sodium taurocholate cotransporting polypeptide(NTCP) inhibitor: Design, synthesis, and anti-proliferative activities被引量：1: 《Chinese Chemical Letters》2020年第6期1422-1426,F0003,共6页Honggang Xiang Yanmei Chen Jifa Zhang jin Zhang Dabo Pan Bo Liu Liang Ouyang; supported by National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2018ZX09735005);the National Natural Science Foundation of China(Nos.81922064,81874290,81673290,81803347 and 81903502);the Natural Science Foundation of Guangdong Province(No.2018A030313707);Post-Doctor Research Project,West China Hospital,Sichuan University(No.2019HXBH034)。; Sodium taurocholate cotransporting polypeptide(NTCP)is identified as the functional receptor for HBV entry,which is responsible for upregulated HBV transcription in the HBV life cycle.Besides,NTCP is also implicated i...; 关键词：Sodium taurocholate cotransporting POLYPEPTIDE (NTCP) Hepatocellular carcinoma(HCC) HBV infection NTCP inhibitor Apoptosis

Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery被引量：5: 《Chinese Chemical Letters》2020年第5期1178-1182,共5页Pan Zheng Yang Liu Jinjin Chen Weiguo Xu Gao Li Jianxun Ding; financially supported by the National Natural Science Foundation of China(Nos.51973216,51873207,51833010,51703225,51673190,51673187,51603204 and 51520105004);the Science and Technology Development Program of Jilin Province(No.20190201068JC);the National Key Research and Development Program of China(No.2016YFC1100701);the Youth Talents Promotion Project of Jilin Province(No.181909);the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2019005)。; Cancer the rapy with nanoscale drug formulations has made significant progress in the past few decades.However,the selective accumulation and release of therapeutic agents in the lesion sites are still great challenge...; 关键词：POLYPEPTIDE TARGETING pH-responsiveness Intracellular drug delivery Cancer therapy

Temperature-sensitive polypeptide brushes-coated mesoporous silica nanoparticles for dual-responsive drug release被引量：1: 《Chinese Chemical Letters》2019年第12期2291-2294,共4页Yahan Cui Rong Deng Xiangshuai Li Xinghuo Wang Qiong Jia Emilie Bertrand Kamel Meguellati Ying-Wei Yang; the Jilin Province-University Cooperative Construction Project-Special Funds for New Materials (No. SXGJSF2017-3) for financial support; A biopolymer-inorganic hybrid system(MSN@PBLGF) is designed and fabricated from mesoporous silica nanoparticles(MSNs) and folic acid(FA)-terminated temperature-sensitive synthetic polypeptide,i.e.,poly(γ-benzyl-L-glu...; 关键词：Biopolymers Dual targeting Mesoporous materials Multi-stimuli responsive Poly(γ-benzyl-L-glutamate)

One-pot photoreduction to prepare NIR-absorbing plasmonic gold nanoparticles tethered by amphiphilic polypeptide copolymer for synergistic photothermal-chemotherapy被引量：6: 《Chinese Chemical Letters》2019年第1期187-191,共5页Siqi Yang Linzhu Zhou Yue Su Rong Zhang Chang-Ming Dong; The National Natural Science Foundation of China (No. 21474061);The Innovation Fund (No. IFPM2016B004) of Shanghai Jiao Tong University & Affiliated Sixth People's Hospital South Campus are appreciated; We developed one-pot photoreduction strategy to prepare near infrared light(NIR)-absorbing plasmonic gold nanoparticles(Au NPs) tethered by amphiphilic polypeptide copolymer poly(L-cysteine)-b-poly(ethylene oxide)(PLC...; 关键词：Near infrared PLASMONIC gold nanoparticles POLYPEPTIDE PHOTOTHERMAL THERAPY Combination THERAPY

Fabrication of virus-like particles with strip-pattern surface：A two-step self-assembly approach被引量：6: 《Chinese Chemical Letters》2017年第4期839-844,共6页Shuo Zhang Chun-Hua Cai Zhou Guan Jia-Ping Lin Xing-Yu Zhu; supported by the National Natural Science Foundation of China(Nos.21234002,51303055,21474029,and51573049);Support from projects of Shanghai municipality(Nos.15QA1401400 and 13JC1402000); Spherical nanostructures with striped patterns on the surfaces resembling the essential structures of natural virus particles were constructed through a two-step self-assembly approach of polystyrene-boligo（acrylic a...; 关键词：Virus-like particles Two-step self-assembly Striped patterns Defects Polypeptide Ordered structure

pH-induced structural changes of surface immobilized poly (L-lysine) by two-dimensional (2D) infrared correlation study: 《Chinese Chemical Letters》2015年第2期173-176,共4页Eun Joo Yoo Boknam Chae Young Mee Jung Seung Woo Lee; supported by Yeungnam University Research Grants in 2013;a Human Resources Development Program of Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant(No.20104010100580) funded by the Korean Ministry of Knowledge Economy; This paper reports the pH-induced structural changes in the surface immobilized poly（L-lysine）（PLL）film.Two-dimensional（2D） correlation analysis was applied to the Fourier transform infrared（FTIR）spectra of th...; 关键词：Poly（L-lysine）（PLL） Surface-immobilized polypeptide FT-IR spectroscopy 2D correlation spectroscopy

A novel plant defensin from Chinese mistletoe,Viscum coloratum (Kom.) Nakai被引量：1: 《Chinese Chemical Letters》2007年第1期55-58,共4页Shi Lei Liu Xiu Bao Du Jing Lin Kong Hui Jiang; A novel polypeptide named as defensin CM was isolated from Chinese mistletoe, Viscum coloratura （Kom.） Nakai. The amino acid sequence was determined by the combination of Edman degradation, endoproteinase Lys-C dige...; 关键词：Viscum coloratura MISTLETOE Primary structure Plant defensin POLYPEPTIDE

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