FLUOROGENIC

作品数：40被引量：29H指数：3
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Structure-based insights into fluorogenic RNA aptamers被引量：1
《Acta Biochimica et Biophysica Sinica》2025年第1期108-118,共11页Qianqian Song Xiaoqing Tai Qianyu Ren Aiming Ren 
supported by the grants from the Natural Science Foundation of China(Nos.32325029,32022039,91940302,and 91640104);the National Key Research and Development Project of China(Nos.2023YFC2604300 and 2021YFC2300300).
Fluorogenic RNA aptamers are in vitro-selected RNA molecules capable of binding to specific fluorophores,significantly increasing their intrinsic fluorescence.Over the past decade,the color palette of fluorescent RNA ...
关键词：fluorogenic RNA aptamers tertiary structures base quadruples base triples fluorescence activation mechanisms G-QUADRUPLEX 
Deciphering the role of mtH_(2)O_(2) in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe
《Science China Chemistry》2025年第1期297-307,共11页Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding PanPan Li Bo Peng Hua Bai Lin Li 
supported by the National Natural Science Foundation of China(62288102,22077101,62475216);the Natural Science Foundation of Shaanxi Province(2022JM-130);the Key Research and Development Program of Shaanxi(2024GH-ZDXM-37);the Innovation Capability Support Program of Shaanxi(2023-CX-PT-23);the Natural Science Basic Research Program of Shaanxi(2024JC-YBQN-0919);the Open Project Program of the Analytical&Testing Center of Northwestern Polytechnical University(2020T018);the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(CPSF)(GZC20240889);the Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University(CX2022034,CX2023098);the Startup Program of XMU(L.L.);Fundamental Research Funds for the Central Universities。
Hepatic ischemia-reperfusion injury(HIRI)is characterized by mitochondrial dysfunction and oxidative stress.Monitoring mitochondrial hydrogen peroxide(mtH_(2)O_(2))levels in real-time through super-resolution imaging ...
关键词：hepatic ischemia-reperfusion injury LOW-BACKGROUND mtH_(2)O_(2)-activatable super-resolution imaging fluorogenic probe 
Recent advances in dual response molecular probes for biothiols
《Smart Molecules》2024年第4期61-87,共27页Master Mwafulirwa Khamis Abdalla Wenhai Bian Hongbei Wei Liren Xu Wanyi Yu Zhang Hui Qi Yang Xiaolong Sun 
XLS thanks the National Natural Science Foundation of China(No.21907080,22278330);the Youth Innovative Team(No.xtr052022012)from Xi'an Jiaotong University;supported by the Natural Science Basic Research Program of Shaanxi(Program No.2023-JC-QN-0246).
The detection of biothiols such as cysteine(Cys),homocysteine(Hcy),and glutathione(GSH)are critical for understanding their roles in biology and their involvement in various physiological and pathological processes.Re...
关键词：biothiols discriminative response dual-mode imaging fluorescent probe fluorogenic detection 
Rationally engineered IR-783 octanoate as an enzyme-activatable fluorogenic tool for functional imaging of h Notum in living systems
《Chinese Chemical Letters》2024年第11期442-447,共6页Lilin Song Mengru Sun Yuqing Song Feng Zhang Bei Zhao Hairong Zeng Jinhui Shi Huixin Liu Shanshan Zhao Tian Tian Heng Yin Guangbo Ge 
supported by National Natural Science Foundation of China(Nos.81922070,81973286,82273897,U23A20516,81801818);Shanghai Municipal Health Commission’s TCM research project(No.2022CX005);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTDD-202004);Three-year Action Plan for Shanghai TCM Development and Inheritance Program(No.ZY(2021-2023)-0401);Department of Science&Technology of Liaoning Province Grant(No.2022JH2/20200056);supported by the State Key Laboratory of Fine Chemicals;Dalian University of Technology(No.KF 2202)。
As a vital negative regulator of Wnt signaling pathway,human Notum(hNotum)plays a crucial regulatory role in the progression of many human diseases.Deciphering the relevance of h Notum to human diseases requires pract...
关键词：hNotum Optical substrate Computer-aided molecular design In-situ functional imaging Cancer diagnosis 
A mitochondria-targeted H_(2)S-activatable fluorogenic probe for tracking hepatic ischemia-reperfusion injury
《Chinese Chemical Letters》2024年第6期370-375,共6页Bin Fang Jiaqi Yang Limin Wang Haoqin Li Jiaying Guo Jiaxin Zhang Qingyuan Guo Bo Peng Kedi Liu Miaomiao Xi Hua Bai Li Fu Lin Li 
financially supported by the National Natural Science Foundation of China(Nos.22077101,22004099);the Joint Research Funds of Department of Science&Technology of Shaanxi Province and Northwestern Polytechnical University(Nos.2020GXLH-Z-008,2020GXLH-Z-021,2020GXLH-Z-023);Natural Science Foundation of Shaanxi Province(No.2022JM-130);The Natural Science Foundation of Ningbo(Nos.202003N4049,202003N4065);the Open Project Program of Wuhan National Laboratory for Optoelectronics(Nos.2020WNLOKF023,2022WNLOKF009);Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University(No.CX2022034);Innovation Capability Support Program of Shaanxi(No.2023-CX-PT-23)。
Hepatic ischemia-reperfusion injury(HIRI)is the cause of postoperative hepatic dysfunction and failure,and even death.As an important biological effector molecule,hydrogen sulfide(H_(2)S)of mitochondria as a gasotrans...
关键词：Mitochondria-targeted Bioimaging H2S-activatable Fluorogenic probe Hepatic ischemia-reperfusion injury(HIRI) 
Advances in FRET-based biosensors from donor-acceptor design to applications被引量：1
《Aggregate》2024年第2期17-38,共22页Wen-Chao Yang Shuang-Yu Li Shengnan Ni Guozhen Liu 
National Natural Science Foundation of China,Grant/Award Numbers:U20A2038,32372584,22174121,22211530067,T2250710180;2022 Natural Science Foundation of Guangdong Provincial Basic and Applied Basic Research Fund(Guangdong Hybribio),Guangdong Peral River Talent Program,Grant/Award Number:2021CX02Y066;Shenzhen Bay Open Laboratory Fund 2021 by Shenzhen Bay Laboratory,CUHK(SZ)-Boyalife Joint Laboratory Fund,CUHK(SZ)-The Second Affiliated Hospital Joint Fund,Grant/Award Number:YXLH2205;University Development Fund,Grant/Award Number:UDF01002012。
Fluorogenic biosensors are essential tools widely used in biomedicine,chemical biology,environmental protection and food safety.Fluorescence resonance energy transfer(FRET)is a crucial technique for developing fluorog...
关键词：BIOIMAGING donor-acceptor pairs fluorescence resonance energy transfer fluorogenic biosensors NANOMATERIALS 
Matthew effect:General design strategy of ultra-fluorogenic nanoprobes with amplified dark–bright states in aggregates
《Aggregate》2024年第2期482-492,共11页Shinsuke Segawa Xinwen Ou Tianruo Shen Tomohiro Ryu Yuki Ishii Herman H.Y.Sung Ian D.Williams Ryan T.K.Kwok Ken Onda Kiyoshi Miyata Xuewen He Xiaogang Liu Ben Zhong Tang 
Hong Kong PhD Fellowship Scheme,Grant/Award Number:PF18-15484;National Natural Science Foundation of China,Grant/Award Numbers:21788102,22274106;Research Grants Council of Hong Kong,Grant/Award Numbers:16306620,16303221,N_HKUST609/19,C6014-20W;Innovation and Technology Commission,Grant/Award Number:ITC-CNERC14SC01;Shenzhen Science and Technology Innovation Committee;JSPS KAKENHI,Grant/Award Numbers:JP23H01977,JP23H04631;JST the establishment of university fellowships towards the creation of science technology innovation,Grant/Award Number:JPMJFS2132。
Fluorescence imaging,a key technique in biological research,frequently utilizes fluorogenic probes for precise imaging in living systems.Tetrazine is an effective emission quencher in fluorogenic probe designs,which c...
关键词：aggregation-induced emission bioorthogonal chemistry click chemistry fluorescence imaging TETRAZINE 
Portable fluorogenic probe for monitoring of volatile amine vapour and food spoilage被引量：1
《Chinese Chemical Letters》2024年第3期257-261,共5页Jian-Hao Zhao Wen-Xing Xu Bin Li Wei Xu Wu-Kun Zhang Ming-Shuai Yuan Hui-Zi Li Qing-Guo He Xiang Ma Jian-Gong Cheng Yan-Yan Fu 
supported by the National Key Research and Development Program of China(No.2022YFB3203500);the National Natural Science Foundation of China(Nos.62022085,61831021);the Science and Technology Commission of Shanghai Municipality(No.22QA1410800)。
There are urgent needs of volatile amine gas sensors with high-performance in food quality control,disease monitoring and environmental pollution.Thin-film fluorescent probe is suitable for amine vapour sensing due to...
关键词：Fluorescent probe Volatile amine Gas sensing TRIMETHYLAMINE Food spoilage 
Fluorogenic sensing of amorphous aggregates,amyloid fibers,and chaperone activity via a near-infrared aggregation-induced emission-active probe
《Aggregate》2024年第1期309-320,共12页Wei He Yuanyuan Yang Yuhui Qian Zhuoyi Chen Yongxin Zheng Wenping Zhao Chenxu Yan Zhiqian Guo Shu Quan 
Natural Science Foundation of Shanghai,Grant/Award Number:23ZR1415300;National Natural Science Foundation of China,Grant/Award Numbers:32222049,31661143021,32171269,32201043;National Key Research and Development Program of China,Grant/Award Number:2022YFF1102900;Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism Shanghai Municipal Education Commission,Grant/Award Number:2021Sci&Tech0328。
The presence of protein aggregates in numerous human diseases underscores the significance of detecting these aggregates to comprehend disease mechanisms and develop novel therapeutic approaches for combating these di...
关键词：aggregation-induced emission fluorescence molecular chaperone protein aggregation 
RNA Imaging in Live Cells
《Chinese Journal of Chemistry》2023年第19期2531-2535,共5页Jingfang Zhao Limin Xiang 
supports from National Key R&D Pro-gram of China(Grant 2022YFA1305400);National Natural Sci-ence Foundation of China(Grant 22104113,Grant 22274122).
Traditional molecular biology tools have elucidated the identities and functions of RNA molecules,which are essential to the understanding of gene transcription and protein translation.Deepening this research field wo...
关键词：Fluorescent imaging RNA imaging Fluorogenic RNA RNA Fluorescent probes RNA recognition 
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