云南高校图书馆联盟文献共享服务平台- PRODRUG

PRODRUG: 作品数：209被引量：333H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张礼和杨振军赵玉芬陈益崔永梅更多>>; 相关机构：北京大学上海大学信息技术有限公司郑州大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划湖北省自然科学基金更多>>

Cooperative bond scission by HRP/H_(2)O_(2)for targeted prodrug activation: 《Chinese Chemical Letters》2024年第12期399-404,共6页Yunkang Tong Haiqiao Huang Haolan Li Mingle Li Wen Sun Jianjun Du Jiangli Fan Lei Wang Bin Liu Xiaoqiang Chen Xiaojun Peng; the National Natural Science Foundation of China(No.22090011);the Fundamental Research Funds for China Central Universities(No.DUT22LAB608)for financial support。; The prodrug strategy provides an opportunity for improving the therapeutic index of drugs and avoid ing their side effects.The main challenge lies in the fast and effective release of the parent drugs at the desired s...; 关键词：PRODRUG ENZYME Tumor microenvironment Hydrogen peroxide Photodynamic therapy Fluorescent probe

Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy被引量：2: 《Chinese Chemical Letters》2024年第10期348-352,共5页Lin Li Bingjun Sun jin Sun Lin Chen Zhonggui He; supported by the National Nature Science Foundation of China(No.81803029);the Science and Technology Foundation of Yuzhong District,Chongqing(No.20210179);the Nature Science Foundation of Chongqing(No.cstc2021jcyjmsxmX1089)。; Chemotherapy has been recommended as the standard protocol for triple-negative breast cancer(TNBC)at the advanced stage.However,the current treatment is unsatisfactory due to inefficient drug accumulation and rapid ch...; 关键词：Prodrug nanoassemblies PACLITAXEL Ferroptosis LAT1 Triple-negative breast cancer

Luminescence-activated Pt(Ⅳ)prodrug for in situ triggerable cancer therapy: 《Chinese Chemical Letters》2024年第7期383-387,共5页Huijie An Chen Yang Zhihui Jiang Junjie Yuan Zhongming Qiu Longhao Chen Xin Chen Mutu Huang Linlang Huang Hongju Lin Biao Cheng Hongjiang Liu Zhiqiang Yu; supported by the National Natural Science Foundation of China(Nos.32201171 and 82372115);the Science and Technology Program of Guangzhou(No.202102021266)。; Anticancer platinum prodrugs that can be controllably activated are highly desired for personalized precision medicine and patient compliance in cancer therapy.However,the clinical application of platinum(Ⅳ)prodrugs(...; 关键词：Tumor microenvironment Endogenous luminescence Platinum(Ⅳ)prodrug Activation strategy ANTITUMOR BIOSAFETY

Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin(Ⅳ) prodrug delivery and enhanced colorectal cancer therapy: 《Chinese Chemical Letters》2024年第4期280-286,共7页Wenjia Wang Xingyue He Xiaojie Wang Tiantian Zhao Osamu Muraoka Genzoh Tanabe Weijia Xie Tianjiao Zhou Lei Xing Qingri Jin Hulin Jiang; financially supported by the National Natural Science Foundation of China (Nos.82020108029, 82073398);supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions and the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University (No.SKLNMZZ202021);the"111"Project from the Ministry of Education of China;the State Administration of Foreign Experts Affairs of China (No.B16046);Double First-Rate construction plan of China Pharmaceutical University (Nos.CPU2018GY06,CPU2022QZ18);China Postdoctoral Science Foundation (Nos.2021M703598, 2022M720173);Jiangsu Funding Program for Excellent Postdoctoral Talent and International Postdoctoral Exchange Fellowship Program 2022。; Oxaliplatin(Oxa) is the first-line chemotherapeutic drug for the treatment of colorectal cancer(CRC). However, long-term Oxa chemotherapy can induce inflammation and increase the levels of cyclooxygenase-2(COX-2) and ...; 关键词：OXALIPLATIN Glutathione depletion Tetravalent platinum prodrug Synergistic therapy Colorectal cancer

Paclitaxel-lipid prodrug liposomes for improved drug delivery and breast carcinoma therapy: 《Chinese Chemical Letters》2024年第2期335-340,共6页Xin Wu Xinmei Chen Xinyu Wang Haisheng He Jianming Chen Wei Wu; supported by National Natural Science Foundation of China(Nos.82273867,82030107);Shanghai Science and Technology Project of Little Giant(No.1902HX76600);Shanghai Qingpu District Industry-University-Research Cooperative Development Funding Project(No.2022-7);High-level Talents of Fujian University of Chinese Medicine(No.X2019006-Talents).; Paclitaxel(PTX)is widely applied for the treatment of unresectable and metastasis breast carcinoma as well as other cancers,whereas its efficacy is always impeded by poor solubility.Liposomes are one kind of the most ...; 关键词：PACLITAXEL LIPIDS PRODRUGS Liposomes Drug release CHEMOTHERAPY

Nanozyme-activating prodrug therapies:A review: 《Chinese Chemical Letters》2024年第2期138-150,共13页Yudong Wu Wujun Chen Chao Wang Dongming Xing; financially supported by the Shandong Provincial Natural Science Foundation of China(No.ZR2021QC088).; Enzyme prodrug therapies(EPTs)have been intensively explored as attractive approaches to selective activation of systemically administered benign prodrugs by the exogenous enzymes or enzymes expressed at the desired t...; 关键词：Enzyme prodrug therapy Nanozyme Prodrug activation CHEMOTHERAPY Drug synthesis

Multifunctional biodegradable nanoplatform based on oxaliplatin prodrug cross-linked mesoporous polydopamine for enhancing cancer synergetic therapy被引量：1: 《Chinese Chemical Letters》2024年第1期379-384,共6页Ping Sun Zimu Li Dan Zhang Wenfeng Zeng Yi Zheng Lin Mei Hongzhong Chen Nansha Gao Xiaowei Zeng; the National Natural Science Foundation of China(Nos.32071342 and 32101065);the Natural Science Foundation of Guangdong Province(Nos.2023A1515012015,2022A1515110271 and 2020A1515011353).; Due to the limitations of conventional chemotherapy including side effects,poor prognosis,and drug resistance,there is an urgent need for the development of a novel multi-functional combined therapy strategy.Dopamine-...; 关键词：Oxaliplatin prodrug Mesoporous polydopamine Charge reversal Synergetic therapy Cancer nanotechnology

PDLLA length on anti-breast cancer efficacy of acid-responsive self-assembling mPEG-PDLLA–docetaxel conjugates: 《Chinese Chemical Letters》2023年第9期225-229,共5页Tao Liu Hui Zou Jingqing Mu Xi Zhang Guohua Liu Na Yu Bo Yuan Xiaoyong Yuan Xingjie Liang Shutao Guo; financially supported by National Natural Science Foundation of China(Nos.32171386 and 32201157);the Natural Science Foundation of Tianjin of China(No.21JCZDJC01250);the China Postdoctoral Science Foundation(No.2021M690793)。; Engineering small-molecule drugs into nanoparticulate formulations provides an unprecedented opportunity to improve the performance of traditional chemo drugs,but suffers from poor compatibility between drugs and nano...; 关键词：NANOMEDICINE PRODRUG DOCETAXEL mPEG-PDLLA Acid-sensitive

Iridium photosensitizer constructed liposomes with hypoxia-activated prodrug to destrust hepatocellular carcinoma: 《Chinese Chemical Letters》2023年第4期110-115,共6页Shuangling Luo Chao Liang Qianling Zhang Pingyu Zhang; the financial support of the National Natural Science Foundation of China (NSFC, Nos. 22077085, 22007104,22177078, 21907069);the Project of the Natural Science Foundation of Guangdong Province (No. 2019A1515011958);the Science and Technology Foundation of Shenzhen (Nos.JCYJ20210324095200002 and JCYJ20190808153209537)。; Hypoxic tumor microenvironment is a major challenge for photodynamic therapy(PDT). To overcome this problem, PDT combined hypoxia-activated chemotherapy is a promising strategy for hypoxic cancer therapy. Herein, a mu...; 关键词：Hypoxia activation Iridium photosensitizer Ferroptosis Photodynamic therapy CHEMOTHERAPY

A GSH-depleted platinum(Ⅳ) prodrug triggers ferroptotic cell death in breast cancer: 《Chinese Chemical Letters》2022年第10期4595-4599,共5页Dachuan Qi Lei Xing Lijun Shen Wenshuang Sun Cheng Cai Chunhua Xue Xuwei Song Hua Yu Hulin Jiang Chengjun Li Qingri Jin Zhiqi Zhang; financially supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions and Double First-classUniversity Projects(No.CPU2018GY06);Six Talent Peaks Projectin Jiangsu Province(No.WSW-112);Zhejiang province basic public welfare research project(No.LGN20C180001);Wenzhou Engineering Research Center of Pet(No.WP02)。; Cisplatin is the first-line drug for treatment of various solid tumors including breast cancer due to the broad anti-tumor spectrum and strong anti-tumor effect.However,serious side effects and long-term medication of...; 关键词：CISPLATIN Ferroptosis Cancer therapy Glutathione depletion Tetravalent platinum prodrug

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