PRODRUG

作品数：211被引量：334H指数：7
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Shape effect of prodrug nanoassemblies on treatment efficacy of cancer therapy
《Nano Research》2025年第2期616-626,共11页Fengxiang Liu Rongzheng Liu Xiaoyuan Fan Xia Wang Kaiyuan Wang Hainan Zhao Hao Ye Shunzhe Zheng Xiao Kuang Yinxian Yang Haotian Zhang Qiming Kan Zhonggui He Jian Chen Jin Sun 
This research was supported by National Natural Science Foundation of China(Nos.82273874 and 82404561);Liaoning Revitalization Talents Program(No.XLYC22202019);the China National Postdoctoral Program for Innovative Talents(No.BX20240233);the Postdoctoral Fellowship Program(Grade B)of China Postdoctoral Science Foundation(No.GZB20240179);the China Postdoctoral Science Foundation(No.2023MD744230);Doctoral Scientific Research Launching Fund Project of Liaoning province(No.2024-BS-075);Prospective Basic research project of 2024 Scientific Research Project of Liaoning Department of Education(No.LJ212410163042).
The tumor microenvironment-sensitive prodrug-based nanoparticles(NPs)have emerged as a promising drug delivery system(DDS).The shape of these particles plays a crucial role in their in vivo behavior.However,non-spheri...
关键词：CAMPTOTHECIN SELF-ASSEMBLY prodrug-based nanoparticles nanorod cancer therapy 
Branched module-modified SN38 prodrug nanoassemblies for improved colorectal cancer therapy:Effectively balance efficacy and safety
《Nano Research》2025年第1期572-585,共14页Qing Wang Shiyi Zuo Shufang Zheng Cuiyun Liu Yaqiao Li Jiayu Guo Danping Wang Shuo Wang Wenjing Wang Bowen Zhang Minglong Huang Xianbao Shi Jin Sun Zhonggui He Bingjun Sun 
gotapproval from the Institutional Animal Ethical Care Committee(IAEC)of Shenyang Pharmaceutical University(ethical code:SYPU-IACUC-2022-0302-010).
The clinical utility of irinotecan is restricted by individual variability in carboxylesterase expression.Direct administration of its active metabolite,7-ethyl-10-hydroxycamptothecin(SN38),presents an appealing alter...
关键词：IRINOTECAN SN38 prodrug nanoassemblies disulfide bonds branched aliphatic chains 
Synergistic enhancement of ultrasound therapy for tumors using hypoxia-activated 6-diazo-5-oxo-L-norleucine(DON)prodrug nanoparticles
《Nano Research》2024年第7期6323-6331,共9页Mengfei Zheng Zhilin Liu Hang Xu Daping Ye Linjie Cui Chenguang Yang Lili Ma Kun Wang Kazuo Sakurai Zhaohui Tang 
financially supported by the Ministry of Science and Technology of China(No.2022YFE0110200);the Natural Science Foundation of Jilin Province(No.20230101037JC);the National Natural Science Foundation of China(Nos.52203198 and 52025035).
Ultrasound(US)has been applied in clinical practice for its non-invasive and high selectivity.However,it is difficult to achieve a satisfactory anti-tumor effect with US alone.Meanwhile,the use of US therapy alone can...
关键词：ultrasound therapy hypoxia-activated prodrug nanoparticles 6-diazo-5-oxo-L-norleucine(DON) glutamine antagonist starvation therapy 
Balancing efficacy and safety of doxorubicin-loaded albumin nanoparticles utilizing pH-sensitive doxorubicin-fatty acid prodrugs
《Nano Research》2024年第6期5491-5500,共10页Yuanhao Yu Shiyi Zuo Jiaxuan Song Lingxiao Li Tian Liu Jiayu Guo Yaqiao Li Danping Wang Qi Lu Helin Wang Dun Zhou Zhonggui He Xiaohong Liu Bingjun Sun Jin Sun 
the National Key R&D Program of China(No.2022YFE0111600);National Natural Science Foundation of China(Nos.82272151 and 82204318)。
Albumin nanoparticles(ANPs)offer unique advantages for antitumor drug delivery system,including non-immunogenicity and inherent tumor-targeting capacity.At present,only a few products,such as ABRAXANE®and FYARRO™,have...
关键词：fatty acid prodrug ALBUMIN DOXORUBICIN pH-sensitive bond NANOMEDICINES 
Fine-tuning the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies via branched aliphatic functionalization被引量：1
《Nano Research》2024年第4期2908-2918,共11页Guanting Li Fengli Xia Hongying Xiao Shunzhe Zheng Shuwen Fu Han Qiao Qianhui Jin Xuanbo Zhang Dun Zhou Chutong Tian Jin Sun Zhonggui He Bingjun Sun 
supported by National Natural Science Foundation of China(Nos.82272151,82204318 and 82173766);Doctoral Scientific Research Staring Foundation of Liaoning Province(No.2021-BS-130);General Program of Department of Education of Liaoning Province(No.LJKZ0953);Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program(No.RC220389).
Small-molecule prodrug nanoassemblies have emerged as efficient antitumor drug delivery systems.However,in the case of camptothecins-based prodrug nanoassemblies,linear aliphatic side chain modification often results ...
关键词：prodrug nanoassembly self-assembly antitumor efficacy TOLERANCE 7-ethyl-10-hydroxycamptothecin(SN_(3)8) 
Research Article Ferric iron coordinated cisplatin prodrug reprograms the immunecold tumor microenvironment through tumor hypoxia relief for enhanced cancer photodynamic-immunotherapy
《Nano Research》2023年第7期9930-9939,共10页Yinchu Ma Yingli Luo Xinfeng Tang Wei Jiang Hongjun Li Jilong Wang 
This work is supported by the National Natural Science Foundation of China(Nos.52103164,and 52173142);Guangdong Basic and Applied Basic Research Foundation(Nos.2021A1515220033 and 2020A1515111059);the Fundamental Research Funds for the Central Universities(No.JUSRP123079).
The microenvironment of hypoxia and immune-cold limits the therapeutic outcomes of immune checkpoint blockade(ICB)therapy in solid tumors.It is important and imperative to search new strategies to relieve tumor hypoxi...
关键词：immunogenic cell death immune response reprograming cold tumor microenvironment long-term immunological memory effect 
Trojan nanobacteria hybridized with prodrug nanocapsules for efficient combined tumor therapy
《Nano Research》2023年第7期9651-9662,共12页Mingsong Zang Yuancheng Ji Xiaoran Ding Zhengwei Xu Jinxing Hou Jianxin Sun Jiayun Xu Shuangjiang Yu Hongcheng Sun Tingting Wang Junqiu Liu 
This work was supported by the National Key Research and Development Program of China(Nos.2020YFA0908500 and 2018YFA0901600);the National Natural Science Foundation of China(Nos.22275046,22161142015,22075065,22001054,and 22201058);the Hangzhou Leading Innovation and Entrepreneurship Team Project(No.TD2022001);the startup fund from Hangzhou Normal University(No.2019QDL026).
Live bacteria-based drug delivery systems have been raised as promising tools for enhancing drug delivery into tumors due to their active tumor targeting and easy surface modifiability.In this work,a“Trojan nanobacte...
关键词：live bacteria hybrid covalent nanocapsule photothermal therapy chemodynamic therapy 
Erratum to:Boosting SN38-based oral chemotherapy to combine reduction-bioactivated structured lipid-mimetic prodrug with ascorbic acid
《Nano Research》2023年第4期6010-6011,共2页Helin Wang Qi Lu Yifan Miao Jiaxuan Song Mingyang Zhang Haotian Zhang Zhonggui He Zixuan Wang Chutong Tian Jin Sun 
Address correspondence to:Chutong Tian,tianct_spu@126.com;Address correspondence to:Jin Sun,sunjin@syphu.edu.cn。
Erratum to Nano Research 2022,15(10):9092-9104 https://doi.org/10.1007/s12274-022-4544-7 Figure 9 was unfortunately mistakenly typeset.This error did not affect any of the conclusions from the published paper.
关键词：chemotherapy FIGURE COMBINE 
Modularly engineered prodrug-nanoassemblies for cancer therapy:Nonpharmacological moiety dominating delivery fates
《Nano Research》2023年第1期980-990,共11页Yuequan Wang Qian Qiu Rui Liao Xinhui Wang Ziran Zhou Xuanbo Zhang Haotian Zhang Zhonggui He Shenwu Zhang Cong Luo Jin Sun 
This work was financially supported by Shenyang Youth Science and Technology Innovation Talents Program(No.RC210452);the Liaoning Revitalization Talents Program(No.XLYC1907129);the Excellent Youth Science Foundation of Liaoning Province(No.2020-YQ-06);the China Postdoctoral Science Foundation(Nos.2020M670794 and 2021MD703858).
Self-engineered small-molecule prodrug-nanoassemblies have emerged as promising nanomedicines for cancer treatment.Modular design of prodrug molecules is crucial to guarantee the favorable assembly stability,tumor-spe...
关键词：small-molecule prodrug PACLITAXEL self-assembly ability nonpharmacological moiety modular engineering delivery fate 
GSH-responsive camptothecin prodrug-based hybrid micellar nanoparticles enable antitumor chemo-immunotherapy by PD-L1 knockdown被引量：1
《Nano Research》2023年第1期834-848,共15页Xi Tan Hong Zhou Chenhui Wang Xuhan Liu Xiangliang Yang Wei Liu 
The authors acknowledge the support by the National Basic Research Program of China(Nos.2020YFA0710700 and 2018YFA0208900);the National Natural Science Foundation of China(No.31470968).
The combinational chemo-immunotherapy as a novel treatment strategy has been widely studied and applied in clinic to enhance antitumor therapeutic efficacy and relieve side effects.RNA interference(RNAi)targeting PD-L...
关键词：camptothecin prodrug hybrid micellar nanoparticles glutathione(GSH)-responsive PD-L1 knockdown chemoimmunotherapy 
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