PRODRUG

作品数：209被引量：333H指数：7
导出分析报告
相关领域：医药卫生更多>>
相关作者：张礼和杨振军赵玉芬陈益崔永梅更多>>
相关机构：北京大学上海大学信息技术有限公司郑州大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划湖北省自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
选择条件：
  • 期刊=Asian Journal of Pharmaceutical Sciencesx
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
A natural compound-empowered podophyllotoxin prodrug nanoassembly magnifies efficacy-toxicity benefits in cancer chemotherapy
《Asian Journal of Pharmaceutical Sciences》2024年第4期103-114,共12页Ziqi Lin Yuequan Wang Wenwen Li Fei Sun Qingzhi Lv Shenwu Zhang Xiaohong Liu Feng Qin Cong Luo 
supported by the Basic Research Projects of Liaoning Provincial Department of Education(LJKZZ20220109);the Shenyang Youth Science and Technology Innovation Talents Program(No.RC210452);the National Natural Science Foundation of China(No.82204317);the Natural Science Foundation of Liaoning Province(No.2022-BS-162).
Small-molecule prodrug nanoassembly technology with a unique advantage in off-target toxicity reduction has been widely used for antitumor drug delivery.However,prodrug activation remains a rate-limiting step for exer...
关键词：Podophyllotoxin PRODRUG CHEMOSENSITIZATION Hybrid nanoassembly Cancer chemotherapy 
Charge adaptive phytochemical-based nanoparticles for eradication of methicillin-resistant staphylococcus aureus biofilms
《Asian Journal of Pharmaceutical Sciences》2024年第3期160-176,共17页Xilong Cui Fanhui Liu Shuang Cai Tingting Wang Sidi Zheng Xinshu Zou Linlin Wang Siqi He Yanhua Li Zhiyun Zhang 
supported by the National Natural Science Foundation of China(No.3210190403);the Natural Science Foundation of Heilongjiang Province(No.YQ2022C016);the China Postdoctoral Science Foundation(2022T150104and 2020M670877);the Postdoctoral Science Foundation of Heilongjiang Province(LBH-TZ2104 and LBH-Z20039);the China Agriculture Research System of MOF and MARA(No.CARS-35)。
The intrinsic resistance of MRSA coupled with biofilm antibiotic tolerance challenges the antibiotic treatment of MRSA biofilm infections.Phytochemical-based nanoplatform is a promising emerging approach for treatment...
关键词：MRSA biofilm ISOLIQUIRITIGENIN Dimer prodrug Charge adaptive Responsive nanoparticles 
Combination therapy to overcome ferroptosis resistance by biomimetic self-assembly nano-prodrug被引量：1
《Asian Journal of Pharmaceutical Sciences》2023年第5期99-111,共13页Yong Huang Yi Lin Bowen Li Fu Zhang Chenyue Zhan Xin Xie Zhuo Yao Chongzhi Wu Yuan Ping Jianliang Shen 
financial supports from National Natural Science Foundation of China(32000992,21977081,32101124);the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholar(LR23C100001);Wenzhou Medical University(KYYW201901);Zhejiang Qianjiang Talent Plan(QJD20020224)
Ferroptosis has emerged as a potent form of no-apoptotic cell death that offers a promising alternative to avoid the chemoresistance of apoptotic pathways and serves as a vulnerability of cancer.Herein,we have constru...
关键词：Self-assembly nano-prodrug Ferroptosis APOPTOSIS Combination therapy 
Impact of the amount of PEG on prodrug nanoassemblies for efficient cancer therapy被引量：5
《Asian Journal of Pharmaceutical Sciences》2022年第2期241-252,共12页Yaqiao Li Lingxiao Li Qianhui Jin Tian Liu Jin Sun Yongjun Wang Zhijun Yang Zhonggui He Bingjun Sun 
financially supported by National Natural Science Foundation of China (no. 81872816);Doctoral Scientific Research Staring Foundation of Liaoning Province (no. 2021BS-130);General Program of Department of Education of Liaoning Province (no. LJKZ0953)
PEGylation has been widely used to improve the pharmacokinetic properties of prodrug self-assembled nanoparticles(prodrug-SANPs).However,the impacts of the amount of PEG on the self-assemble stability,cellular uptake,...
关键词：PEGYLATION PRODRUG Self-assembly nanoparticles DOCETAXEL Oxidation responsive 
Carrier-free prodrug nanoparticles based on dasatinib and cisplatin for efficient antitumor in vivo被引量：2
《Asian Journal of Pharmaceutical Sciences》2021年第6期762-771,共10页Lu Yang Jiaxi Xu Zheng Xie Faquan Song Xin Wang Rupei Tang 
supported by the National Natural Science Foundation of China(No.51803001 and 51503001);the Natural Science Foundation of Anhui Province(No.2008085ME136 and 2008085QE210);the Research Foundation of Education Department of Anhui Province of China(No.KJ2018ZD003,KJ2018A0006 and KJ2019A0015);the Academic and Technology Introduction Project of Anhui University(AU02303203)grant.
Carrier-free drug self-delivery systems consisting of amphiphilic drug-drug conjugate(ADDC)with well-defined structure and nanoscale features have drawn much attention in tumor drug delivery.Herein,we report a simple ...
关键词：PRODRUG NANOPARTICLE DASATINIB CISPLATIN 
Iron-doxorubicin prodrug loaded liposome nanogenerator programs multimodal ferroptosis for efficient cancer therapy被引量：6
《Asian Journal of Pharmaceutical Sciences》2021年第6期784-793,共10页Yinxian Yang Shiyi Zuo Linxiao Li Xiao Kuang Jinbo Li Bingjun Sun Shujun Wang Zhonggui He Jin Sun 
supported by the National Natural Science Foundation of China(no.81872816);the Liaoning Revitalization Talents Program(no.XLYC180801);China Postdoctoral Innovative Talents Support Program(no.BX20190219);China Postdoctoral Science Foundation(no.2019M661134).
Ferroptosis is a new mode of cell death,which can be induced by Fenton reactionmediated lipid peroxidation.However,the insufficient H2O2 and high GSH in tumor cells restrict the efficiency of Fenton reaction-dependent...
关键词：Ferroptosis Iron LIPOSOME Redox PRODRUG 
Investigating the crucial roles of aliphatic tails in disulfide bond-linked docetaxel prodrug nanoassemblies被引量：5
《Asian Journal of Pharmaceutical Sciences》2021年第5期643-652,共10页Yuequan Wang Cong Luo Shuang Zhou Xinhui Wang Xuanbo Zhang Shumeng Li Shenwu Zhang Shuo Wang Bingjun Sun Zhonggui He Jin Sun 
funding from the National Natural Science Foundation of China(No.81703451 and 81773656);the Excellent Youth Science Foundation of Liaoning Province(No.2020-YQ-06);the Liaoning Revitalization Talents Program(No.XLYC1808017 and XLYC1907129);the China Postdoctoral Science Foundation(No.2020M670794);the Science and Technology Major Project of Liaoning(No.2019JH1/10300004)。
Disulfide bond-bridging strategy has been extensively utilized to construct tumor specificity-responsive aliphatic prodrug nanoparticles(PNPs) for precise cancer therapy. Yet, there is no research shedding light on th...
关键词：DOCETAXEL Aliphatic prodrug Disulfide bond Self-assembly capacity In vivo drug delivery fate 
Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies被引量：7
《Asian Journal of Pharmaceutical Sciences》2021年第3期337-349,共13页Lingxiao Li Shiyi Zuo Fudan Dong Tian Liu Yanlin Gao Yinxian Yang Xin Wang Jin Sun Bingjun Sun Zhonggui He 
This work was supported by China Postdoctoral Innovative Talents Support Program(no.BX20190219);China Postdoctoral Science Foundation(no.2019M661134);National Natural Science Foundation of China(no.81872816).
Homodimeric prodrug-based self-assembled nanoparticles,with carrier-free structure and ultrahigh drug loading,is drawing more and more attentions.Homodimeric prodrugs are composed of two drug molecules and a pivotal l...
关键词：Diselenide bond Homodimeric prodrug DOCETAXEL Self-assembly Redox responsive 
The design and synthesis of dextran-doxorubicin prodrug-based pH-sensitive drug delivery system for improving chemotherapy efficacy被引量：5
《Asian Journal of Pharmaceutical Sciences》2020年第5期605-616,共12页Xiaoli Zhang Tian Zhang Xianbin Ma Yajun Wang Yi Lu Die Jia Xiaohua Huang Jiucun Chen Zhigang Xu Feiqiu Wena 
supported by Science and Technology Project from the Science Technology and Innovation Committee of Shenzhen Municipality(JCYJ20170817170110940 and JCJY20170307163529489);the Sichuan Science and Technology Program(2018JY0392 and 2018GZYZF0008);Sanming Project of Medicine in Shenzhen(SZSM201512033);Shenzhen Public Service Platform of Molecular Medicine in Pediatric Hematology and Oncology。
Tumor cells show acidic conditions compared with normal cells,which further inspires scientist to build nanocarrier responsive to tumor microenvironment(TME)for enhancing tumor therapeutic efficacy.Here,we report a pH...
关键词：DEXTRAN CHEMOTHERAPY PRODRUG Tumor acidic microenvironment Controlled release 
Oxidation-strengthened disulfide-bridged prodrug nanoplatforms with cascade facilitated drug release for synergetic photochemotherapy被引量：2
《Asian Journal of Pharmaceutical Sciences》2020年第5期637-645,共9页Bin Yang Lin Wei Yuequan Wang Na Li Bin Ji Kaiyuan Wang Xuanbo Zhang Shenwu Zhang Shuang Zhou Xiaohui Yao Hang Song Yusheng Wu Haotian Zhang Qiming Kan Tao Jin Jin Sun 
financially supported by National Nature Science Foundation of China(No.81872816,81703451);Liaoning Revitalization Talents Program,No XLYC1808017;Key projects of Technology bureau in Shenyang,No18400408;Key projects of Liaoning Province Department of Education,No.2017LZD03;supported by Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region。
One of the major barriers in utilizing prodrug nanocarriers for cancer therapy is the slow release of parent drug in tumors.Tumor cells generally display the higher oxidative level than normal cells,and also displayed...
关键词：Prodrug nanoplatform Disulfide bond Pyropheophorbide a Redox-heterogeneity Accurate therapy 
全选清除导出
共2页<12>
检索报告 对象比较 聚类工具 使用帮助 返回顶部