云南高校图书馆联盟文献共享服务平台- MONOCROTALINE

MONOCROTALINE: 作品数：20被引量：73H指数：4; 导出分析报告; 相关作者：秦玉明贲晓明梁瑛罗保生李奋更多>>; 相关机构：中国药科大学中国科学院上海第二医科大学附属新华医院武汉大学更多>>; 相关期刊：《Hepatobiliary & Pancreatic Diseases International》《Chinese Medical Journal》《天然产物研究与开发》《Chinese Journal of Integrative Medicine》更多>>; 相关基金：国家自然科学基金北京市自然科学基金广东省自然科学基金更多>>

Experimental animal models of pulmonary hypertension:Development and challenges被引量：3: 《Animal Models and Experimental Medicine》2022年第3期207-216,共10页Xiao-Han Wu Jie-Ling Ma Dong Ding Yue-Jiao Ma Yun-Peng Wei Zhi-Cheng Jing; CAMS Innovation Fund for Medical Sciences (CIFMS):2021-I2M-1-018。; Pulmonary hypertension(PH) is clinically divided into 5 major types, characterized by elevation in pulmonary arterial pressure(PAP) and pulmonary vascular resistance(PVR), finally leading to right heart failure and de...; 关键词：animal models BMPR2 chronic hypoxia MONOCROTALINE pulmonary hypertension Sugen 5416

Early Intervention of Tongxinluo(通心络) on Right Ventricular Function Assessed by Echocardiography in Rats with Pulmonary Arterial Hypertension Induced by Monocrotaline: 《Chinese Journal of Integrative Medicine》2020年第12期913-920,共8页GAO Lu LI Shao-dan ZHANG Yin LIU Yi YANG Ming-hui; Supported by National Key Basic Research Special Foundation of China(No.2012CB518600)。; Objective:To investigate the effect of early intervention of Tongxinluo(通心络,TXL)on right ventricular function(RVF)of rats with pulmonary arterial hypertension(PAH)induced by monocrotaline(MCT).Methods:A total of 30...; 关键词：TONGXINLUO early intervention pulmonary arterial hypertension right ventricular function ECHOCARDIOGRAPHY

3-Bromopyruvate alleviates the development of monocrotalineinduced rat pulmonary arterial hypertension by decreasing aerobic glycolysis,inducing apoptosis,and suppressing inflammation被引量：2: 《Chinese Medical Journal》2020年第1期49-60,共12页Jie Liu Wang Wang Lei Wang Xian-Mei Qi Yu-Hui Sha Ting Yang; This work was supported by grants from the National Natural Science Foundation of China(No.31600939);the Beijing Natural Science Foundation(No.7174280);the Beijing Talents Training Project(No.2015000020124G111).; Background:Pulmonary arterial hypertension(PH)is a progressive disease with limited therapeutic options,ultimately leading to right heart failure and death.Recent findings indicate the role of the Warburg effect(aerob...; 关键词：Pulmonary arterial hypertension MONOCROTALINE 3-Bromopyruvate Aerobic glycolysis

An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families: 《Chinese Journal of Natural Medicines》2019年第7期490-497,共8页CHEN Jia-Yin Jürgen Brockmoller Mladen V.Tzvetkov WANG Li-Jun CHEN Xi-Jing; supported by the Natural Science Foundation of Guangdong Province(No.2018A0303100026);German Research Foundation(DFG) Grant Clinical Research Group “Genotype-phenotype relationships and neurobiology of the longitudinal course of psychosis” in work package 3(No. BR2471/1-1) and DFG Grant(No. TZ74/1-1); Current study systematically investigated the interaction of two alkaloids, anisodine and monocrotaline, with organic cation transporter OCT1, 2, 3, MATE1 and MATE2-K by using in vitro stably transfected HEK293 cells....; 关键词：ANISODINE MONOCROTALINE Organic CATION TRANSPORTER OCT MATE

Salvianolic acid A attenuates vascular remodeling in pulmonary arterial hypertension rats induced by monocrotaline: 《中国药理学与毒理学杂志》2018年第4期279-280,共2页Lian-hua FANG Yu-cai CHEN Tian-yi YUAN Yang LYU Guan-hua DU; supported by National Natural Science Foundation of China(81773935;81573645;81603101); CAMS Innovation Fund for Medical Sciences(2017-I2M-1-010); OBJECTIVE Salvianolic acid A(SAA) is one of the most bioactive compounds from a traditional Chinese medicine called Dan Shen(Salvia Miltiorrhiza Bunge) and exhibits many pharmaco.logical activities.Previous studies ha...; 关键词：丹酚酸中药丹参治疗方法

Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model被引量：14: 《Acta Pharmacologica Sinica》2016年第6期772-782,共11页Yu-cai CHEN Tian-yi YUAN Hui-fang ZHANG Dan-shu WANG Yu YAN Zi-ran NIU Yi-huang LIN Lian-hua FANG Guan-hua DU; Aim： The current therapeutic approaches have a limited effect on the dysregulated pulmonary vascular remodeling, which is characteristic of pulmonary arterial hypertension （PAH）. In this study we examined whether s...; 关键词：salvianolic acid A Dan Shen BOSENTAN MONOCROTALINE pulmonary artery hypertension vascular remolding APOPTOSIS BMPRII SMAD

Application of Precision-Cut Rat Liver Slice to Study the Influence of Monocrotaline, Tussilago farfara Alkaloids on the Expression of Cytochrome P450 Enzymes: 《Health》2016年第4期370-379,共10页Hailin Wang Lianqiang Hui Chun Li Ting Liu Chang’an Yu Chunyu Cao Ran Hao Yi Zhang; Precision-cut liver slice has been successfully used to study the mechanism of drug-induced hepatotoxicity, the prediction of liver toxicity, the discovery of early hepatic toxicity biomarker and the metabolism of dru...; 关键词：Precision-Cut Liver Slices MONOCROTALINE Tussilago farfara Alkaloids Hepatotoxity Cytochrome P450 Enzymes

The potential therapeutic effect DL0805-2 on experimental pulmonary hypertensive rats and the underlying mechanisms: 《中国药理学通报》2015年第B11期60-61,共2页; Aim DL0805-2 is a novel Rho-kinases inhibitor which has been found to have potent cardiovascular effects. In the present research, we aimed to study the potential of DL0805-2 in the treatment of pulmonary arterial hyp...; 关键词：DL0805-2 PULMONARY ARTERY hypertension MECHANISMS MONOCROTALINE Rho/ROCK pathway inflamma-tion vascular REMODELING

Abnormal expression of vesicular transport proteins in pulmonary arterial hypertension in monocrotaline-treated rats被引量：2: 《Acta Biochimica et Biophysica Sinica》2015年第3期156-163,共8页Hongliang Zhang Qin Luo Zhihong Liu YongWang Zhihui Zhao; Intracellular vesicular transport is shown to be dysfunctional in pulmonary arterial hypertension （PAH）. However, the expression of intracellular vesicular transport proteins in PAH remains unclear. To elucidate the...; 关键词：pulmonary arterial hypertension MONOCROTALINE vesicular transport

4epatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in mice被引量：4: 《Acta Pharmacologica Sinica》2014年第2期292-300,共9页Jun YAO Cheng-gang LI Li-kun GONG Chen-chen FENG Chun-zhu LI Man GAO Yang LUAN Xin-ming Qi Jin REN; Aim：Monocrotaline （MCT） in plants of the genus Crotalaria induces significant toxicity in multiple organs including the liver, lung and kidney. Metabolic activation of MCT is required for MCT-induced toxicity. In t...; 关键词：MONOCROTALINE pyrrolizidine alkaloid hepatic cytochrome P450s KETOCONAZOLE metabolic activation hepatic toxicity renaltoxicity

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