ANISODINE

作品数：9被引量：3H指数：1
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相关领域：医药卫生更多>>
相关作者：卢强吴艳芬仉文升吕雯潘思源更多>>
相关机构：北京大学北京中医药大学香港科技大学更多>>
相关期刊：《Mechanobiology in Medicine》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Science Bulletin》更多>>
相关基金：国家自然科学基金广东省自然科学基金更多>>
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Anisodine hydrobromide alleviates oxidative stress caused by hypoxia/reoxygenation in human cerebral microvascular endothelial cells predominantly via inhibition of muscarinic acetylcholine receptor 4
《BIOCELL》2023年第10期2255-2263,共9页WENLI JIANG JUNYI SHEN XIAOQIANG DU YAN QIU JIAN ZHONG ZHI OUYANG BINGMEI M.FU YE ZENG 
funding from the National Natural Science Foundation of China(12272246);the Key Research and Development Projects of Sichuan Province(2023YFS0075).
Background:Anisodine hydrobromide(AT3),an anti-cholinergic agent,could be delivered to the brain across the blood-brain barrier and has been used clinically for the treatment of cerebral ischemia/reperfusion injury.En...
关键词：HYPOXIA/REOXYGENATION Endothelial cell Anisodine hydrobromide Muscarinic acetylcholine receptors Hypoxia-inducible factor-1α 
Improvement of hemodynamics in mesenteric microcirculation in septic shock rats by anisodamine and anisodine被引量：2
《Mechanobiology in Medicine》2023年第1期51-60,共10页Jian Zhong Zhi Ouyang Junyi Shen Ye Zeng 
supported by the National Natural Science Foundation of China 12272246;the Key Research and Development Projects of Sichuan Province 2023YFS0075.
Anisodamine and anisodine have been used in treatment of septic shock,but the underlying mechanism are still unclear.In the present study,the effects of anisodamine hydrobromide(Ani HBr)and anisodine hydrobromide(AT3)...
关键词：SEPSIS MICROCIRCULATION HEMODYNAMICS Flow pattern LEUKOCYTE ANISODAMINE ANISODINE 
An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families
《Chinese Journal of Natural Medicines》2019年第7期490-497,共8页CHEN Jia-Yin Jürgen Brockmoller Mladen V.Tzvetkov WANG Li-Jun CHEN Xi-Jing 
supported by the Natural Science Foundation of Guangdong Province(No.2018A0303100026);German Research Foundation(DFG) Grant Clinical Research Group “Genotype-phenotype relationships and neurobiology of the longitudinal course of psychosis” in work package 3(No. BR2471/1-1) and DFG Grant(No. TZ74/1-1)
Current study systematically investigated the interaction of two alkaloids, anisodine and monocrotaline, with organic cation transporter OCT1, 2, 3, MATE1 and MATE2-K by using in vitro stably transfected HEK293 cells....
关键词：ANISODINE MONOCROTALINE Organic CATION TRANSPORTER OCT MATE 
Asymmetric Synthesis of Anisodine
《Chinese Chemical Letters》2005年第10期1287-1289,共3页Yan Fen WU Wen LUE Qiang LU Wen Sheng ZHANG 
Anisodine was synthesized from 3α-hydroxy-6β-acetyltropine in 11 steps. Laevorotary isomer of anisodine was prepared from the asymmetric dihydroxylation of compound 10 via the osmium catalyzed process employing p-ch...
关键词：ANISODINE tropine alkaloid total synthesis. 
Total Synthesis of Anisodine被引量：1
《Journal of Chinese Pharmaceutical Sciences》2005年第1期13-17,共5页吴艳芬 卢强 吕雯 仉文升 
Aim To design a practical synthetic route of anisodine. Methods Starting from3α-hydroxy-6β-acetyltropine, anisodine was synthesized in 11 steps. Result Anisodine wasobtainded with an overall yield of 2.6 % . Conclus...
关键词：ANISODINE tropine alkaloid total synthesis 
Learning deficits induced by 4 belladonna alkaloids are preferen-tially attenuated by tacrine
《Acta Pharmacologica Sinica》2000年第2期30-36,共7页潘思源 韩怡凡 
AIM: To examine the antagonism of tacrine on the amnesic effects of scopolamine (Sco), anisodine (AT3), atropine (Atr), and anisodamine (Ani). METHODS: Cognitive functions and locomotor activities were determined usin...
关键词：TACRINE SCOPOLAMINE ANISODINE at-ropine ANISODAMINE belladonna alkaloids avoidance-learning memory motor activity 
~3H—LABELLING OF BELLADONNA ALKALOIDS BY CATALYSED EXCHANGE WITH MICROWAVE EXCITATION
《Nuclear Science and Techniques》1992年第3期171-174,共4页张丽明 郑冬珠 袁建民 蒋晓马 赵夏令 
The Project Supported by National Natural Science Foundation of China
The ~3H-labelled belladonna alkaloids obtained by catalysed exchange method with microwave excitation was investigated. The specific activities of the labelled products Were 16—32 TBq/mol. More than 90% labelled posi...
关键词：~3H- NMR MICROWAVE catalysed EXCHANGE ~3H-anisodamine hydrobromide ~3H-anisodine ~3H-Atropine sulfate ~3H-scopolamine ~3H-labelling 
STRUCTURE AND ABSOLUTE CONFIGURATION OF ANISODINE HYDROBROMIDE
《Chinese Science Bulletin》1988年第16期1397-1399,共3页鲍光宏 徐常富 贺存恒 穆善田 
Anisodine is a noval anticholinergic drug extracted from the Datura plant Scoplia tangutic. Its chemical characteristics and pharmacological effects have been investigated. in detail.
关键词：ANISODINE hydromide ABSOLUTE CONFIGURATION X-RAY DIFFRACTION method 
EFFECT OF ANISODINE ON THE CORTICAL SINGLE NEURON DISCHARGE IN RATS
《Chinese Science Bulletin》1985年第6期839-843,共5页郑永芳 鲍光宏 
Anisodine is an antioholinergic new drug extracted from a varioty of Datura plants, scoplia tangutica. The chemical structure and the nature of pharmacology of this drug are similar to scopolamine. This drug has small...
关键词：PHARMACOLOGY DATURA toxicity DWELL INTRAVENOUS firing ANESTHESIA devoted sequential inhibiting 
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