SPHINGOSINE

作品数：80被引量：236H指数：8
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相关领域：医药卫生更多>>
相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Shuangshen Granules Suppress Myeloid-derived Suppressor Cell-mediated Lung Premetastatic Niche Development by Targeting Sphingosine-1-Phosphate Receptor-1/Signal Transducer,Activator of Transcription 3 Signaling
《World Journal of Traditional Chinese Medicine》2024年第4期485-494,共10页Rui Liu Jia-Qi Hu Xing Zhang Xiao-Yi Wu Hua-Min Wei Yuan-Chen Zhao Shu-Lin He Jing Yu Xin Qi Ying-Xia Pei Hong Chen Wei-Dong Li Bao-Jin Hua 
supported by the Special Training of Scientific and Technological Talents,China Academy of Chinese Medical Sciences (grant number ZZ13-YQ-023,ZZ13-YQ-028);the National Natural Science Foundation of China(grant number 82174465,82074338,82274609,82104961,82174463);the Beijing Municipal Science and Technology Commission (grant number Z181100001618006);Scientificand Technological Innovation Project of China Academy of Chinese Medical Sciences (grant number CI2021A01810,CI2021A01814,CI2021A01808,CI2021B009);Traditional Chinese Medicine Innovation Team Project of the National Administration of Traditional Chinese Medicine(grant number ZYYCXTD-C-202205);Central High-Level Traditional Chinese Medicine Hospital Clinical Research and Achievement Transformation Capacity Enhancement Project-Special Project Inheriting the Academic Experienceof Renowned Traditional Chinese Medicine Experts(HLCMHPP2023012);China Academy of Chinese Medical Sciences Special Project for Research and Development of Superior Diseases,Hospital Preparations,New Drugs(ZZ15-XY-PT-01);Xu Hang Project for Cultivating Young Top Talents at Guang'anmen Hospital (CZ40908);The Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ17XRZ-023);Clinical Research Expenses of the Central High-level Hospital of Traditional Chinese Medicine (HLCMHPP2023101)
Background:Shuangshen granule s(SSGs) are extensively utilized for the treatment of lung cancer in China and have been reported to possess tumor-protective and anti-metastatic effects.Therefore,it is crucial to unders...
关键词：Lung metastasis myeloid‑derived suppressor cell premetastatic niche Shuangshen granules sphingosine‑1‑phosphate receptor‑1/signal transducer activator of transcription 3 axis 
Cystathionineγ-lyase-derived H_(2)S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase
《Acta Pharmacologica Sinica》2024年第11期2366-2379,共14页You-tian Hu Zhi-wei Liu Tong-hui Zhang Yu-e Ma Lei He Jie Zhang Yue-yang Zhou Antonio Vidal-Puig De-jing Pan Fang Wu 
supported by the National Natural Science Foundation of China(32271304,31500635,21834005,31771299);Research Fund of Medicine and Engineering of Shanghai Jiao Tong University(YG2021QN144);National Key R&D Program of China(2018YFA0801100);National Center for International Research of Genomics(2017B01012).
Thymic egress is a crucial process for thymocyte maturation,strictly regulated by sphingosine-1-phosphate lyase(S1PL).Recently,cystathionineγ-lyase(CSE),one of the enzymes producing hydrogen sulfide(H_(2)S),has emerg...
关键词：immune cells thymic egress hydrogen sulfide S1P lyase redox motif NSC4056 
Approach to loss of response to advanced therapies in inflammatory bowel disease被引量：1
《World Journal of Gastroenterology》2024年第22期2902-2919,共18页Nikil Vootukuru Abhinav Vasudevan 
BACKGROUND Remarkable progress over the last decade has equipped clinicians with many options in the treatment of inflammatory bowel disease.Clinicians now have the unique opportunity to provide individualized treatme...
关键词：Inflammatory bowel disease Ulcerative colitis CROHN BIOLOGICS Interleukin-12 and interleukin-23 inhibitors Alpha-beta7-integrin inhibitors Janus kinase inhibitors Sphingosine-1-phosphate receptor modulators 
Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling被引量：3
《Acta Pharmacologica Sinica》2024年第1期98-111,共14页Shuang Yang Hou-wei Li Jia-ying Tian Zheng-kai Wang Yi Chen Ting-ting Zhan Chun-yue Ma Min Feng Shifeng Cao Yu Zhao Xue Li Jing Ren Qian Liu Lu-ying Jin Zhi-qi Wang Wen-yu Jiang Yi-xiu Zhao Yan Zhang Xue Liu 
supported by National Natural Science Foundation of China(82170431,81870259,81903608).
Restenosis after angioplasty is caused usually by neointima formation characterized by aberrant vascular smooth muscle cell(VSMC)dedifferentiation.Myeloid-derived growth factor(MYDGF),secreted from bone marrow-derived...
关键词：carotid artery balloon injury neointimal formation VSMC dedifferentiation MYDGF Sphingosine-1-phosphate receptor 2 
The contributions of bacteria metabolites to the development of hepatic encephalopathy
《Liver Research》2023年第4期296-303,共8页Miranda Claire Gilbert Tahereh Setayesh Yu-Jui Yvonne Wan 
the USA National Institutes of Health(NIH)R01CA222490.
Over 20%of mortality during acute liver failure is associated with the development of hepatic encephalopathy(HE).Thus,HE is a complication of acute liver failure with a broad spectrum of neuropsychiatric abnormalities...
关键词：LIVER Gut-liver-brain axis Bile acids(BAs) Bile acid(BA)receptors Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) Brain 
Sphingosine phosphate lyase insufficiency syndrome:a systematic review
《World Journal of Pediatrics》2023年第5期425-437,共13页Zahra Pournasiri Abbas Madani Fatemeh Nazarpack John A.Sayer Zahra Chavoshzadeh Fatemeh Nili Paulina Tran Julie D.Saba Mahnaz Jamee 
Background Sphingosine-1-phosphate lyase insufficiency syndrome(SPLIS)or nephrotic syndrome type-14 is caused by biallelic mutations in SGPL1.Here,we conducted a systematic review to delineate the characteristics of S...
关键词：Nephrotic syndrome type 14 Immunodeficiency LYMPHOPENIA Sphingosine-1-phosphate lyase 1 Sphingosine-1-phosphate lyase insufficiency syndrome 
Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma被引量：1
《Neural Regeneration Research》2023年第4期840-848,共9页Devaraj Basavarajappa Vivek Gupta Nitin Chitranshi Roshana Vander Wall Rashi Rajput Kanishka Pushpitha Samridhi Sharma Mehdi Mirzaei Alexander Klistorner Stuart L.Graham 
This investigator-initiated study grant(to SLG)was funded by Novartis,Australia;the funding support from the National Health and Medical Research Council(NHMRC)of Australia,Perpetual Hilcrest,Ophthalmic Research Institute of Australia(ORIA);Macquarie University,NSW,Australia。
Sphingosine-1-phosphate receptor(S1PR)signaling regulates diverse pathophysiological processes in the central nervous system.The role of S1PR signaling in neurodegenerative conditions is still largely unidentified.Sip...
关键词：GLAUCOMA intraocular pressure NEURODEGENERATION NEUROPROTECTION optic nerve injury retinal ganglion cells siponimod sphingosine-1-phosphate 
Fingolimod protects against neurovascular unit injury in a rat model of focal cerebral ischemia/reperfusion injury被引量：5
《Neural Regeneration Research》2023年第4期869-874,共6页Xiao-Yu Zhu Ting-Ting Ma Yang Li Ming-Qi Zhang Liang Zhao Jia Liang Lian-Qiu Min 
supported by grants from the National Natural Science Foundation of China,No.81971231(to JL);Liaoning Revitalization Talents Program,No.XLYC1907178(to JL)。
Recent research on the underlying mechanisms of cerebral ischemia indicates that the neurovascular unit can be used as a novel subject for general surveys of neuronal damage and protein mechanisms.Fingolimod(FTY-720)i...
关键词：astrocyte blood-brain barrier CLAUDIN-5 FTY-720 INTERLEUKIN-17A ischemic stroke neural protection neurovascular unit OCCLUDIN sphingosine-1-phosphate receptor 1 
Sphingosine-1-phosphate derived from PRP-Exos promotes angiogenesis in diabetic wound healing via the S1PR1/AKT/FN1 signalling pathway被引量：4
《Burns & Trauma》2023年第1期229-244,共16页Tianyi Chen Peiyang Song Min He Shunli Rui Xiaodong Duan Yu Ma David G.Armstrong Wuquan Deng 
supported by the Chongqing Youth High-end Talent Studio(Grant No.ZQNYXGDRCGZS2021008);the fund of Sichuan Provincial Western Psychiatric Association’s CSPC LEADING Scientific Research Project(Grant No.WL2021002);the Natural Science Foundation of Chongqing Municipal Science and Technology Bureau(CSTB2022NSCQ-MSX0489);partially supported by National Institutes of Health,National Institute of Diabetes and Digestive and Kidney Diseases Award Number 1R01124789-01A1;National Science Foundation(NSF)Center to Stream Healthcare in Place(#C2SHiP)CNS Award Number 2052578 awarded to DGA.
Background:Sphingosine-1-phosphate(S1P),a key regulator of vascular homeostasis and angiogenesis,is enriched in exosomes derived from platelet-rich plasma(PRP-Exos).However,the potential role of PRP-Exos-S1P in diabet...
关键词：EXOSOMES Platelet-rich plasma Diabetic foot ulcer Wound healing Sphingosine-1-phosphate 
S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung被引量：3
《Acta Pharmaceutica Sinica B》2023年第3期1110-1127,共18页Mengyao Hao Rong Fu Jun Tai Zhenhuan Tian Xia Yuan Yang Chen Mingjin Wang Huimin Jiang Ming Ji Fangfang Lai Nina Xue Liping Bai Yizhun Zhu Xiaoxi Lv Xiaoguang Chen Jing Jin 
supported by National Key Research&Development Program from the Ministry of Science and Technology of the PRC(No.2019YFE0111800,China);National Natural Science Foundation of China(No.81872923,China);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-JKCS-016,China);The Science and Technology Development Fund,Macao SAR(No.0074/2019/AMJ,China).
Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease with unclear etiology and limited treatment options.The median survival time for IPF patients is approximately 2–3 years and there is no effective inter...
关键词：Idiopathic pulmonary fibrosis Endothelial barrier Tight junction Sphingosine-1-phosphate receptor 1 Sphingosine-1-phosphate receptor 1 agonist FTY720 IMMH002 Protein stability 
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