SPHINGOSINE

作品数：80被引量：236H指数：8
导出分析报告
相关领域：医药卫生更多>>
相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
-
在结果中检索

检索结果分析

结果分析中...
选择条件：
  • 学科=医药卫生—临床医学x
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Approach to loss of response to advanced therapies in inflammatory bowel disease被引量：1
《World Journal of Gastroenterology》2024年第22期2902-2919,共18页Nikil Vootukuru Abhinav Vasudevan 
BACKGROUND Remarkable progress over the last decade has equipped clinicians with many options in the treatment of inflammatory bowel disease.Clinicians now have the unique opportunity to provide individualized treatme...
关键词：Inflammatory bowel disease Ulcerative colitis CROHN BIOLOGICS Interleukin-12 and interleukin-23 inhibitors Alpha-beta7-integrin inhibitors Janus kinase inhibitors Sphingosine-1-phosphate receptor modulators 
The contributions of bacteria metabolites to the development of hepatic encephalopathy
《Liver Research》2023年第4期296-303,共8页Miranda Claire Gilbert Tahereh Setayesh Yu-Jui Yvonne Wan 
the USA National Institutes of Health(NIH)R01CA222490.
Over 20%of mortality during acute liver failure is associated with the development of hepatic encephalopathy(HE).Thus,HE is a complication of acute liver failure with a broad spectrum of neuropsychiatric abnormalities...
关键词：LIVER Gut-liver-brain axis Bile acids(BAs) Bile acid(BA)receptors Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) Brain 
Sphingosine phosphate lyase insufficiency syndrome:a systematic review
《World Journal of Pediatrics》2023年第5期425-437,共13页Zahra Pournasiri Abbas Madani Fatemeh Nazarpack John A.Sayer Zahra Chavoshzadeh Fatemeh Nili Paulina Tran Julie D.Saba Mahnaz Jamee 
Background Sphingosine-1-phosphate lyase insufficiency syndrome(SPLIS)or nephrotic syndrome type-14 is caused by biallelic mutations in SGPL1.Here,we conducted a systematic review to delineate the characteristics of S...
关键词：Nephrotic syndrome type 14 Immunodeficiency LYMPHOPENIA Sphingosine-1-phosphate lyase 1 Sphingosine-1-phosphate lyase insufficiency syndrome 
Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma被引量：1
《Neural Regeneration Research》2023年第4期840-848,共9页Devaraj Basavarajappa Vivek Gupta Nitin Chitranshi Roshana Vander Wall Rashi Rajput Kanishka Pushpitha Samridhi Sharma Mehdi Mirzaei Alexander Klistorner Stuart L.Graham 
This investigator-initiated study grant(to SLG)was funded by Novartis,Australia;the funding support from the National Health and Medical Research Council(NHMRC)of Australia,Perpetual Hilcrest,Ophthalmic Research Institute of Australia(ORIA);Macquarie University,NSW,Australia。
Sphingosine-1-phosphate receptor(S1PR)signaling regulates diverse pathophysiological processes in the central nervous system.The role of S1PR signaling in neurodegenerative conditions is still largely unidentified.Sip...
关键词：GLAUCOMA intraocular pressure NEURODEGENERATION NEUROPROTECTION optic nerve injury retinal ganglion cells siponimod sphingosine-1-phosphate 
Fingolimod protects against neurovascular unit injury in a rat model of focal cerebral ischemia/reperfusion injury被引量：5
《Neural Regeneration Research》2023年第4期869-874,共6页Xiao-Yu Zhu Ting-Ting Ma Yang Li Ming-Qi Zhang Liang Zhao Jia Liang Lian-Qiu Min 
supported by grants from the National Natural Science Foundation of China,No.81971231(to JL);Liaoning Revitalization Talents Program,No.XLYC1907178(to JL)。
Recent research on the underlying mechanisms of cerebral ischemia indicates that the neurovascular unit can be used as a novel subject for general surveys of neuronal damage and protein mechanisms.Fingolimod(FTY-720)i...
关键词：astrocyte blood-brain barrier CLAUDIN-5 FTY-720 INTERLEUKIN-17A ischemic stroke neural protection neurovascular unit OCCLUDIN sphingosine-1-phosphate receptor 1 
S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung被引量：3
《Acta Pharmaceutica Sinica B》2023年第3期1110-1127,共18页Mengyao Hao Rong Fu Jun Tai Zhenhuan Tian Xia Yuan Yang Chen Mingjin Wang Huimin Jiang Ming Ji Fangfang Lai Nina Xue Liping Bai Yizhun Zhu Xiaoxi Lv Xiaoguang Chen Jing Jin 
supported by National Key Research&Development Program from the Ministry of Science and Technology of the PRC(No.2019YFE0111800,China);National Natural Science Foundation of China(No.81872923,China);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-JKCS-016,China);The Science and Technology Development Fund,Macao SAR(No.0074/2019/AMJ,China).
Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease with unclear etiology and limited treatment options.The median survival time for IPF patients is approximately 2–3 years and there is no effective inter...
关键词：Idiopathic pulmonary fibrosis Endothelial barrier Tight junction Sphingosine-1-phosphate receptor 1 Sphingosine-1-phosphate receptor 1 agonist FTY720 IMMH002 Protein stability 
Sphingosine-1-phosphate derived from PRP-Exos promotes angiogenesis in diabetic wound healing via the S1PR1/AKT/FN1 signalling pathway被引量：4
《Burns & Trauma》2023年第1期229-244,共16页Tianyi Chen Peiyang Song Min He Shunli Rui Xiaodong Duan Yu Ma David G.Armstrong Wuquan Deng 
supported by the Chongqing Youth High-end Talent Studio(Grant No.ZQNYXGDRCGZS2021008);the fund of Sichuan Provincial Western Psychiatric Association’s CSPC LEADING Scientific Research Project(Grant No.WL2021002);the Natural Science Foundation of Chongqing Municipal Science and Technology Bureau(CSTB2022NSCQ-MSX0489);partially supported by National Institutes of Health,National Institute of Diabetes and Digestive and Kidney Diseases Award Number 1R01124789-01A1;National Science Foundation(NSF)Center to Stream Healthcare in Place(#C2SHiP)CNS Award Number 2052578 awarded to DGA.
Background:Sphingosine-1-phosphate(S1P),a key regulator of vascular homeostasis and angiogenesis,is enriched in exosomes derived from platelet-rich plasma(PRP-Exos).However,the potential role of PRP-Exos-S1P in diabet...
关键词：EXOSOMES Platelet-rich plasma Diabetic foot ulcer Wound healing Sphingosine-1-phosphate 
Unveiling the biological role of sphingosine-1-phosphate receptor modulators in inflammatory bowel diseases被引量：4
《World Journal of Gastroenterology》2023年第1期110-125,共16页Evanthia Tourkochristou Athanasia Mouzaki Christos Triantos 
Inflammatory bowel disease(IBD)is chronic inflammation of the gastrointestinal tract that has a high epidemiological prevalence worldwide.The increasing disease burden worldwide,lack of response to current biologic th...
关键词：Inflammatory bowel disease Sphingosine-1-phosphate Intestinal inflammation T helper 1/T helper 17 Sphingosine 1 phosphate Modulators Immune responses 
Sphingosine-1-Phosphate Protects Against the Development of Cardiac Remodeling via Sphingosine Kinase 2 and the S1PR2/ERK Pathway
《Current Medical Science》2022年第4期702-710,共9页Hui YAN Hu ZHAO Shao-wei YI Hang ZHUANG Dao-wen WANG Jian-gang JIANG Gui-fen SHEN 
supported by the National Natural Science Foundation of China(No.81873505).
Objective:Cardiac remodeling is a common pathological change in various cardiovascular diseases and can ultimately result in heart failure.Thus,there is an urgent need for more effective strategies to aid in cardiac p...
关键词：sphingosine-l-phosphate cardiac remodeling sphingosine kinase 2 sphingosine-1-phosphate receptor extracellular regulated protein kinase 
Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways被引量：2
《International Journal of Oral Science》2022年第2期192-200,共9页Bongkun Choi Ji-Eun Kim Si-On Park Eun-Young Kim Soyoon Oh Hyuksu Choi Dohee Yoon Hyo-Jin Min Hyung-Ryong Kim Eun-Ju Chang 
supported by a National Research Foundation of Korea(NRF)MRC grant(2018R1A5A2020732);by a grant of the Basic Science and Engineering Research Program(2018R1A2B2001867)funded by the Korean government to E.J.C.;by the Bio&Medical Technology Development Program(NRF2017M3A9E4047243)funded by the Ministry of Science,ICT and Future Planning,the Republic of Korea to H.R.K.
Sphingosine-1-phosphate(S1P)is an important lipid mediator that regulates a diverse range of intracellular cell signaling pathways that are relevant to tissue engineering and regenerative medicine.However,the precise ...
关键词：PULP hinder PRECISE 
全选清除导出
共5页<12345>
检索报告 对象比较 聚类工具 使用帮助 返回顶部