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A dynamic N^6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors被引量：22
《Cell Research》2018年第11期1062-1076,共15页Fei Yan Aref AI-Kali Zijie Zhang Jun Liu Jiuxia Pang Na Zhao Chuan He Mark R. Litzow Shujun Liu 
N^6-methyladenosine （m^6A） on mRNAs is critical for various biological processes, yet whether m^6A regulates drug resistance remains unknown. Here we show that developing resistant phenotypes during tyrosine kinase ...
关键词：酷氨酸 调整 MRNA 蛋白质合成 生物过程 调查结果 FTO 机械学 
Entosis, a key player in cancer cell competition被引量：2
《Cell Research》2014年第11期1280-1281,共2页Guido Kroemer 
Cell-in-cell structures, also referred to as ＇entosis＇, are frequently found in human malignancies, although their prognostic impact remains to be defined. Two articles recently published in Cell Research report the...
关键词：癌细胞 S期 竞争 球员 肿瘤抑制基因 细胞结构 恶性肿瘤 生物过程 
Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system被引量：17
《Cell Research》2014年第2期247-250,共4页Pei Zhao Zhe Zhang Hongmei Ke Yiren Yue Ding Xue 
Dear Editor, Technologies to achieve specific and precise genome editing, such as knock-in and knock-out, are critical for deciphering the functions of a gene and for under- standing fundamental biological processes. ...
关键词：靶基因 编辑 寡核苷酸 线虫 系统 基因组 基因敲除 生物过程 
Essential role of Fbx114 ubiquitin ligase in regulation of vertebrate axis formation through modulating Mkp3 level被引量：1
《Cell Research》2012年第5期936-940,共5页
The F-box family of proteins （FBPs）, the substrate- recognition components of the Skpl-Cull-F-box-protein （SCF） ubiquitin ligase, are evolutionarily conserved in various species and exhibit key roles in a wide arr...
关键词：蛋白质水平 泛素连接酶 脊椎动物 哺乳动物细胞 轴 MAP激酶 物种进化 生物过程 
Essential role of DOT IL in maintaining normal adul hematopoiesis被引量：2
《Cell Research》2011年第9期1370-1373,共4页
Dear Editor, Histone methylation plays important roles in regulating gene expression and diverse biological processes [1 ]. Methylation of a unique residue, lysine 79 of histone H3 （H3K79）, is evolutionarily conser...
关键词：白细胞介素 造血功能 交通部 组蛋白甲基化 组蛋白H3 生物过程 基因表达 人类进化 
Effective gene silencing in Drosophila ovarian germline by artificial microRNAs被引量：3
《Cell Research》2011年第4期700-703,共4页Hailong Wang YanJun Mu Dahua Chen 
Dear Editor, Drosophila oogenesis is of great interest because it represents an excellent model system to study a number of fascinating biological processes, such as stem cell regulation, germ cell meiosis and oocyte...
关键词：生殖细胞 小分子RNA 卵巢管 基因沉默 果蝇 人工 生物过程 模型系统 
Recent progress in the epigenetics and chromatin field被引量：3
《Cell Research》2011年第3期373-374,共2页Guest editors Yi Zhang 
In eukaryotic cells, the genome is packaged into chromatin by wrapping DNA around histones. Studies in the past decade revealed that chromatin is not a static structure. In response to developmental and environmental ...
关键词：染色质结构 表观遗传学 真核细胞 动态调整 生物过程 DNA 组蛋白 基因组 
A special issue on NF-kB signaling and function被引量：8
《Cell Research》2011年第1期1-2,共2页
Since its discovery about 25 years ago, the NF-kB signaling pathway has remained one of the exciting and extensively studied fields of biomedical research. It is of no doubt that NF-kB functions as an essential intrac...
关键词：信号通路 生物医学 胞内信使 细胞基因 环境信号 生物过程 细胞生长 免疫反应 
A systematic evaluation of the compatibility of histones containing methyl-lysine analogues with biochemical reactions被引量：1
《Cell Research》2009年第10期1217-1220,共4页Guangshuai Jia Weixiang Wang Hong Li Zhuo Mao Gaihong Cai Jian Sun Hui Wu Mo Xu Peng Yang Wen Yuan She Chen Bing Zhu 
Dear Editor, Histone lysine methylation has received a great deal of attention from the chromatin field over the past 10 years. To date, histone lysine methylations have been demonstrated to play pivotal roles in near...
关键词：赖氨酸 组蛋白 生化反应 系统评价 类似物 兼容 DNA修复 生物过程 
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