supported by the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement(801165),with co-funding through Science Foundation Ireland,Career Development Award(17/CDA/4733);supported by the National Natural Science Foundation of China(12204088,11974069 and U21A2074);Liaoning Revitalization Talents Program(XLYC1902113);the Science and Technology Project of Liaoning Province(2020JH2/10100012)。