We thank the National Key R&D Program of China(2021YFA1500200);the National Natural Science Foundation of China(92056105,92256303,22221002,and 22188101);the Haihe Laboratory of Sustainable Chemical Transformations,the Fundamental Research Funds for the Central Universities,and the Frontiers Sciences Center for New Organic Matter at Nankai University(63181206)for financial support.
The design and synthesis of spirochroman-2-on-4,1'-indan-7'-ol(SCIOL)and its application for synthesizing chiral monophosphinite ligands are reported.The synthesis features a tandem double Friedel-Crafts reaction/lact...
A metal-organic framework (MOF) formulated as [Cd2(μ3-L)2(DMF)4]·H2O (CdL) [H2L=9-(pyridin-4-yl)- 9H-carbazole-3,6-dicarboxylic acid, DMF=N,N-dimethylformamide] was synthesized under solvothermal condition...
A simple and efficient protocol has been developed for the synthesis of 3-phenylnaphtho[2,3-b]furan-4,9-diones by domino reaction of a-bromonitroalkenes to 2-hydroxynaphthalene-1,4-dione. With the optimal reaction con...
Application of the Suzuki cross-coupling reaction for efficient synthesis of diverse substituted biaryl-chromen- 4-ones using an optimized palladium(0) catalyst system is reported. The coupling of arylboronic acids ...
A convenient and efficient method for the synthesis of pyrazolo[3,4-d]pyrimidin-4-ones via heterocyclization reaction of 5-amino-lH-pyrazole-4-carboxamides with triethyl orthoesters using two BrCnsted-acidic ionic liq...
Project supported by the National Natural Science Foundation of China (No. 20902073), the Natural Science Foundation of Gansu Province (No. 096RJZA116) and Scientific and Technological Innovation Engineering Program of Northwest Normal University (No. nwnu-kjcxgc-03-64).
A highly efficient synthesis of novel pyrido[2,3-d]pyrimidin-4-ols was developed via an iodine-catalyzed tandem oxidative cyclization under focused microwave irradiation. Pyrido[2,3-d]pyrimidin-4-ols were obtained fro...
Project supported by the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (09KJA430003), Natural Science Foundation of Xuzhou City (XM09B016), Graduate Foundation of Xuzhou Normal University (09YLB030) and Qing Lan Project (08QLT001).
A series of novel fused tetracyclic benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4(3H)-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-thiopyran-3,5(4H,6H)-dione, and 1H-benzo[d]imidaz...
Project supported by the National Natural Science Foundation of China (No. 20672016).
3-Alkyl-2-alkyliminooxazolidin-4-ones were prepared from a copper-catalyzed domino intermolecular nucleophilic addition of a-hydroxy-(or mecapto) carboxylic acid ester to carbodiimide and a followed nucleophilic sub...
A new method for the synthesis of azo Schiff an base ligand in which the azo and azomethine groups are coordination sites was developed through a Schiff base precursor. The precursor, N-4-methoxybenzylidene-3-hydroxyp...
Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent t...