NEURAL_STEM_CELL

作品数：153被引量：663H指数：13
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  • 期刊=Neural Regeneration Researchx
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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases
《Neural Regeneration Research》2025年第6期1582-1598,共17页Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia 
supported by the Natural Science Foundation of Heilongjiang Province of China,Outstanding Youth Foundation,No.YQ2022H003 (to DW)。
N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis a...
关键词：Alzheimer's disease cell self-renewal central nervous system MEMORY MICROGLIA nerve regeneration neurodegenerative diseases NEUROGENESIS RNA methylation 
New insights on the role of chondroitin sulfate proteoglycans in neural stem cell–mediated repair in spinal cord injury
《Neural Regeneration Research》2025年第6期1699-1700,共2页Seyed Mojtaba Hosseini Soheila Karimi-Abdolrezaee 
funding support from the Canadian Institutes of Health Research;supported by a Doctoral Studentship from the Wings for Life Foundation。
Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord under...
关键词：PEROXIDATION FISCHER INJURY 
Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury
《Neural Regeneration Research》2025年第5期1416-1430,共15页Mou Gao Qin Dong Dan Zou Zhijun Yang Lili Guo Ruxiang Xu 
supported by the National Natural Science Foundation of China,Nos.82271397(to MG),82001293(to MG),82171355(to RX),81971295(to RX),and 81671189(to RX)。
Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells ...
关键词：Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell MICROGLIA NEUROINFLAMMATION 
Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis被引量：1
《Neural Regeneration Research》2025年第3期821-835,共15页Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu 
supported by the Fundamental Research Program of Shanxi Province of China,No.20210302124277;the Science Foundation of Shanxi Bethune Hospital,No.2021YJ13(both to JW)。
Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive impairment.However,the mechanism underlying this neurogenesis impairment remains unknown.In ...
关键词：complement C1 dendrite dentate gyrus hippocampus neural stem cell NEUROGENESIS NEUROINFLAMMATION neurological function neuron traumatic brain injury 
Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke
《Neural Regeneration Research》2025年第3期845-857,共13页Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi 
supported by the Natural Science Foundation of Jiangsu Province of China,No.BK20211348(to SHQ);Xuzhou Basic Research Program,No.KC21030(to LYH);Leadership Program of Xuzhou Medical University,No.JBGS202203(to SHQ);Research Grant Council GRF of Hong Kong Special Administrative Region of China,No.17105220(to JGS)。
It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late stroke.Indeed,previous studies have shown that excessive increases ...
关键词：cell differentiation cerebral ischemia/reperfusion injury CHLORINATION hypochlorous acid MICROGLIA neural stem cell NEUROGENESIS nuclear translocation stroke β-catenin 
Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis
《Neural Regeneration Research》2025年第2期518-532,共15页Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei 
supported by the National Natural Science Foundation of China,No.8227050826(to PL);Tianjin Science and Technology Bureau Foundation,No.20201194(to PL);Tianjin Graduate Research and Innovation Project,No.2022BKY174(to CW).
Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor prognosis.Human-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)...
关键词：AKT ASTROCYTE blood-brain barrier cerebral edema EXOSOMES human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells NEUROINFLAMMATION PI3K 
Emerging strategies for nerve repair and regeneration in ischemic stroke:neural stem cell therapy被引量：5
《Neural Regeneration Research》2024年第11期2430-2443,共14页Siji Wang Qianyan He Yang Qu Wenjing Yin Ruoyu Zhao Xuyutian Wang Yi Yang Zhen-Ni Guo 
supported by the National Natural Science Foundation of China,No.81971105(to ZNG);the Science and Technology Department of Jilin Province,No.YDZJ202201ZYTS677(to ZNG);Talent Reserve Program of the First Hospital of Jilin University,No.JDYYCB-2023002(to ZNG);the Norman Bethune Health Science Center of Jilin University,No.2022JBGS03(to YY);Science and Technology Department of Jilin Province,Nos.YDZJ202302CXJD061,20220303002SF(to YY);Jilin Provincial Key Laboratory,No.YDZJ202302CXJD017(to YY).
Ischemic stroke is a major cause of mortality and disability worldwide,with limited treatment options available in clinical practice.The emergence of stem cell therapy has provided new hope to the field of stroke trea...
关键词：bystander effect cell replacement extracellular vesicles ischemic stroke neural stem cells neural stem cell engineering 
High-frequency repetitive transcranial magnetic stimulation promotes neural stem cell proliferation after ischemic stroke被引量：8
《Neural Regeneration Research》2024年第8期1772-1780,共9页Jing Luo Yuan Feng Zhongqiu Hong Mingyu Yin Haiqing Zheng Liying Zhang Xiquan Hu 
supported by the National Natural Science Foundation of China,Nos.81672261(to XH),81972151(to HZ),82372568(to JL);the Natural Science Foundation of Guangdong Province,Nos.2019A1515011106(to HZ),2023A1515030080(to JL)。
Prolife ration of neural stem cells is crucial for promoting neuronal regeneration and repairing cerebral infarction damage.Transcranial magnetic stimulation(TMS)has recently emerged as a tool for inducing endogenous ...
关键词：AKT/β-catenin signaling brain stimulation Ca2+influx cell proliferation ischemic stroke middle cerebral artery occlusion neural stem cells neurological rehabilitation repetitive transcranial magnetic stimulation 
Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease被引量：3
《Neural Regeneration Research》2024年第7期1593-1601,共9页Bo Li Yujie Chen Yan Zhou Xuanran Feng Guojun Gu Shuang Han Nianhao Cheng Yawen Sun Yiming Zhang Jiahui Cheng Qi Zhang Wei Zhang Jianhui Liu 
supported by the National Natural Science Foundation of China,Nos.82171194 and 81974155(both to JL);the Shanghai Municipal Science and Technology Commission Medical Guide Project,No.16411969200(to WZ);Shanghai Municipal Science and Technology Commission Biomedical Science and Technology Project,No.22S31902600(to JL)。
Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheime...
关键词：Alzheimer’s disease mitochondrial biogenesis neural stem cell-derived exosome SIRT1-PGC1α regional brain distribution whole brain clearing and imaging 
Epigenetic memory of drug exposure history controls neural stem cell quiescence in the adult brain
《Neural Regeneration Research》2024年第4期711-712,共2页Masakazu Iwamoto Taito Matsuda 
supported by a Grant-in-Aid for Scientific Research(B)JP21H02808(to TM);JST SPRING JPMJSP2136(to MI)。
Neural stem cells(NSCs)are the source of all neurons and glial cells(astrocytes and oligodendrocytes)in the central nervous system.The adult mammalian brain retains NSCs in the subgranular zone of the dentate gyrus in...
关键词：NEURAL INTEGRATE continuously 
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