云南高校图书馆联盟文献共享服务平台- OLTIPRAZ

OLTIPRAZ: 作品数：10被引量：17H指数：2; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：柏华李中骞罗贤懋贾燕胡国刚更多>>; 相关机构：中国医学科学院北京协和医学院匹兹堡大学锦州医科大学中国医学科学院中国协和医科大学更多>>; 相关期刊：《Progress in Natural Science:Materials International》《中华疾病控制杂志》《中国实验动物学报》《Acta Pharmacologica Sinica》更多>>; 相关基金：国家自然科学基金更多>>

Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain被引量：8: 《Acta Pharmacologica Sinica》2020年第8期1041-1048,共8页Ya-qun Zhou Dai-qiang Liu Shu-ping Chen Nan Chen Jia Sun Xiao-mei Wang Fei Cao Yu-ke Tian Da-wei Ye; the National Natural Science Foundation of China(Grant Nos.81873732,81400917,81371250,and 81571053).; Paclitaxe-induced neuropathic pain(PINP)is refractory to currently used analgesics.Previous studies show a pivotal role of oxidative stressin PINP.Because the nuclear factor erythroid-2-related factor 2(Nrf2)has been ...; 关键词：PACLITAXEL neuropathic pain oxidative stress NRF2 HO-1 OLTIPRAZ

Exploration of the mechanisms of Aflatoxin B1 toxicity and the targets of Oltipraz by reverse docking: 《Journal of Chinese Pharmaceutical Sciences》2014年第3期182-185,共4页张裕郭丽梅; Aflatoxin B1 toxicity is well known but the mechanism of this toxicity is still unclear. In addition, the target of the anti-aflatoxin chemopreventive drug Oltipraz remains to be identified. In this study, we employed...; 关键词：Reverse docking Aflatoxin B1 OLTIPRAZ

Keap1 eye on the target:chemoprevention of liver cancer被引量：2: 《Acta Pharmacologica Sinica》2007年第9期1331-1342,共12页Melinda Sue YATES Thomas Wells KENSLER; This work was supported by NIH grants(№ CA39416,CA94076,and ES06052);Melinda Sue YATES was supported by T32(№ GM08763); Hepatocellular carcinoma （HCC） is one of the most common cancers worldwide, causing nearly 600000 deaths each year. Increased risk of HCC due to chronic infection with hepatitis B virus （HBV） and exposure to dieta...; 关键词：CHEMOPREVENTION Kelch ECH associating protein 1 Nrf2 SULFORAPHANE OLTIPRAZ TRITERPENOIDS dithiolethiones hepatocellular carcinoma

Quantification of mRNA by RT-competitive-PCR and high performance liquid chromatography: 《Progress in Natural Science:Materials International》2002年第5期353-358,共6页Gary WILLIAMSON; Supported by the Biotechnology and Biological Sciences Research Council, UK; The use of RT-competitive-PCR with high performance liquid chromatography (HPLC) detection to quantify the absolute number of mRNA copies in mammalian cells is reported. As an example, the glutathione transferase (GS...; 关键词：RT-PCR GLUTATHIONE transferase oltipraz HEP G2 cell HPLC.

Chemopreventive effect of oltipraz on AFB_1-induced hepatocarcinogenesis in tree shrew model被引量：5: 《World Journal of Gastroenterology》2000年第5期647-650,共4页TW Kensler BD Roebuck; USPHS grant CA-39416.; INTRODUCTIONHepatocellular carcinoma (HCC) is one of themajor cancers in the world with a mortality of morethan 250 000 cases yearly.More than 137 000 casesof HCC were diagnosed each year in China,whichacount approxim...; 关键词：hepatocellular carcinoma tupajidae AFLATOXIN B1 hepatitis B virus incidence CARCINOGENS environmental

Oltipraz对人肺癌变早期的抑制效应及其影响某些基因表达的研究: 《基础医学与临床》1999年第3期38-42,共5页柏华罗贤懋魏慧娟胡国刚冯益民李中骞; 目的：探讨oltipraz对人肺早期癌变是否有阻断作用及其作用的分子机制。方法：人胚肺组织培养，光镜病理检查、ELISA法分析GST-π蛋白含量，比色法测GSTs活性，免疫组化分析mP53基因表达。结果：病理分析显示oltipraz阻断人肺早期癌变在...; 关键词：OLTIPRAZ 肺癌变肺肿瘤 P53 基因表达治疗

人肺癌变早期阻断及其分子机制研究被引量：1: 《生理科学进展》1998年第3期235-238,共4页柏华; 以人胚肺为实验材料，进行了ｏｌｔｉｐｒａｚ对人肺癌变早期阻断及其分子机制的研究。结果显示：ｏｌｔｉｐｒａｚ阻断人肺癌变在香烟凝聚物（ＣＳＣ）运用前或同时运用效果较好；ｏｌｔｉｐｒａｚ阻断人肺癌变时能使谷胱甘肽－Ｓ－转...; 关键词：OLTIPRAZ 基因表达调控肺癌变 GST-Π 早期阻断

黄曲霉毒素与原发性肝癌关系的研究进展被引量：1: 《中华疾病控制杂志》1998年第3期214-217,共4页陈爱民; 关键词：原发性肝癌黄曲霉毒素暴露 DNA加成物 P53基因突变密码子 HBV感染 OLTIPRAZ 血清白蛋白 P53基因突变 F344大鼠

Oltipraz防癌抑癌作用研究进展: 《国外医学（肿瘤学分册）》1997年第6期333-334,共2页柏华罗贤懋; 就十字花科蔬菜中的提取物oltipraz防癌抑癌的劝物实验结果和人体干预试验作了回顾,并探讨其防治癌症的可能机制。oltipraz主要影响一些代谢解毒酶类如GSTs、AFAR等的代谢和相关基因的表达。; 关键词：OLTIPRAZ 防癌抑癌药物筛选

Oltipraz对细胞恶性转化抑制作用的研究: 《中国实验动物学报》1997年第1期41-46,共6页柏华罗贤懋魏慧娟胡国刚李中骞; 国家自然科学基金; 选用人胚肺为实验材料，研究了十字花科蔬菜提取物ｏｌｔｉｐｒａｚ对人肺癌病变早期细胞恶性转化的阻断作用。将阻断按时间分为ｏｌｔｉｐｒａｚ在ＣＳＣ作用前、后和同时三组，并设ＣＳＣ、ｏｌｔｉｐｒａｚ、ＤＭＳＯ三组对照，将上...; 关键词：CSC 细胞恶性转化人肺癌阻断作用人胚早期恶性转化细胞接种鉴定十字花科蔬菜琼脂培养

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