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Dicoumarol is an effective post-exposure prophylactic for SARS-CoV-2 Omicron infection in human airway epithelium
《Signal Transduction and Targeted Therapy》2023年第7期3455-3465,共11页Yang Peng Shi-ying Chen Zhao-ni Wang Zi-qing Zhou Jing Sun Gui-an Zhang Jia Li Lei Wang Jin-cun Zhao Xiao Xiao Tang De-Yun Wang Nan-shan Zhong 
The authors would like to thank the study participants who donated their samples for the advancement of scientific knowledge.The authors would also like to thank Dr.Jennie Wong(from the Medical and Scientific Communication,Research Support Unit,Yong Loo Lin School of Medicine,National University of Singapore,Singapore)for assistance in the language editing of this manuscript.This work was supported by The National High-Level Talents Program(X.X.T.),Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01S155);Guangzhou Institute of Respiratory Health Open Project(X.X.T.);the Postdoctoral Science Foundation of China(2022M710897,Y.P.);the Postdoctoral Startup Foundation of Guangzhou City(Y.P.);Zhongnanshan Medical Foundation of Guangdong Province(ZNSA-2020013,Z.Q.Z.).
Repurposing existing drugs to inhibit SARS-CoV-2 infection in airway epithelial cells(AECs)is a quick way to find novel treatments for COVID-19.Computational screening has found dicoumarol(DCM),a natural anticoagulant...
关键词：OMI INFECTION EPITHELIUM 
Structural characteristics of the SARS-CoV-2 Omicron lineages BA.1 and BA.2 virions被引量：1
《Signal Transduction and Targeted Therapy》2023年第4期1381-1383,共3页Xiaoyu Ma Yanqun Wang Yuanzhu Gao Yiliang Wang An Yan Jiantao Chen Lu Zhang Peiyi Wang Jincun Zhao Zheng Liu 
the Cryo-electron Microscopy Center,Southern University of Science and Technology,for their assistance with data collection.This work was supported by the National Natural Science Foundation of China(82070329 to Z.L.,82172240 to Y.W.,82025001 to J.Z.).
Dear Editor,Variants of concern(VOCs)of SARS-CoV-2 have increased transmissibility,virulence,and resistance.The emergence of new VOCs continues to pose great challenges to public health.The detailed structures of the ...
关键词：characteristics OMI resistance. 
Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes被引量：3
《Signal Transduction and Targeted Therapy》2023年第1期10-12,共3页Rayhane Nchioua Federica Diofano Sabrina Noettger Pascal von Maltitz Steffen Stenger Fabian Zech Jan Münch Konstantin M.J.Sparrer Steffen Just Frank Kirchhoff 
supported by the DFG(CRCs 1279 and 1506);the EU commission(Fight-nCoV);the MWK and the BMBF(Restrict-SARS-CoV-2,IMMUNOMOD).
Dear Editor,Since its first description in South Africa in November 2021,the SARS-CoV-2 Omicron variant rapidly outcompeted the previously dominating Delta variant.Omicron is the fifth variant of concern(VOC).It conta...
关键词：STRONG neutral OMI 
Limited cross-variant neutralization after primary Omicron infection:consideration for a variant-containing booster
《Signal Transduction and Targeted Therapy》2022年第9期3174-3176,共3页Harold Marcotte Lennart Hammarstrom Qiang Pan-Hammarstrom 
H.M,L.H,and Q.P.H.are supported by the European Union's Horizon 2020 research and innovation program under grant agreement No 101003650(ATAC);the Swedish Research Council,and the Knut and Alice Wallenberg Foundation(KAW).
In a recent study published in Nature,Suryawanshi et al.showed that primary Omicron infection only elicits a mild humoral immune response and limited cross-variant neutralization in non-vaccinated individuals.1On the ...
关键词：BREAKTHROUGH immunity OMI 
Omicron:increased transmissibility and decreased pathogenicity被引量：2
《Signal Transduction and Targeted Therapy》2022年第6期1865-1867,共3页Gábor Bálint Barbara Vörös-Horváth Aleksandar Széchenyi 
Three research papers were published recently to compare the virological properties of the Omicron variant with the earlier variants of concern(VOC).1,2,3 The SARS-CoV-2 B.1.1.529 variant,Omicron,was first detected in...
关键词：OMI EARLIER REPRODUCTION 
PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron
《Signal Transduction and Targeted Therapy》2022年第6期1885-1887,共3页Jingyi Su Jing Zheng Wei Huang Yali Zhang Cairui Lv Baoding Zhang Lina Jiang Tong Cheng Quan Yuan Ningshao Xia Jianming Zhang Li Li Li Li Xianming Deng 
supported by grants from the National Key R&D Program and the National Natural Science Foundation of China(No.2017YFA0504504,22025702,82021003,91853203,82151211 to X.Deng,and 82073874 to L.Li);the Fundamental Research Funds for the Central Universities of China(No.20720200008 to X.Deng);Health Science and Technology Program of Fujian Province(No.2020CXB050 to J.Zheng);the Program of Introducing Talents of Discipline to Universities(111 Project,B06016).
Dear Editor,COVID-19 pandemic,caused by SARS-CoV-2 infection,is raging around the world and results in millions of deaths since the end of 2019.Although various therapies including vaccines and neutralizing antibodies...
关键词：OMI NEUTRAL WORRY 
Vaccination versus SARS-CoV-2 Omicron:three vaccine doses win the battle
《Signal Transduction and Targeted Therapy》2022年第5期1373-1374,共2页Grzegorz Maria Popowicz Krzysztof Pyrc Kamyar Hadian 
This work is supported by the Bayerische Forschungsstiftung grant AZ-1453-20C(to G.M.P.);the Deutsche Forschungsgemeinschaft,grants PO 1851/4-1(to G.P.);subsidy from the Polish Ministry of Science and Higher Education for research on SARS-CoV-2 and a grant from the National Science Center(UMO-2017/27/B/NZ6/02488)and by EU-Horizon2020 ITN OrganoVir grant 812673(to K.P).Open Access funding enabled and organized by Project DEAL.
The here highlighted study by Garcia-Beltran et al.demonstrates that SARS-CoV-2 Omicron can largely escape the immune responses.Hence,while two doses of COVID-19 vaccines seem to be insufficient to provide protection ...
关键词：doses NEUTRAL OMI 
Sequential immunizations confer cross-protection against variants of SARS-CoV-2,including Omicron in Rhesus macaques被引量：5
《Signal Transduction and Targeted Therapy》2022年第5期1746-1755,共10页Wei Deng Qi Lv Fengdi Li Jiangning Liu Zhiqi Song Feifei Qi Qiang Wei Pin Yu Mingya Liu Shasha Zhou Yaqing Zhang Hong Gao Nan Wang Zijing Jia Kai Gao Jiayi Liu Chong Xiao Haiquan Shang Xiangxi Wang Linlin Bao Chuan Qin 
ACKNOWLEDGEMENTS We thank Sinovac Biotech Ltd for providing the inactivated vaccines as a gift for these prospective studies.This work was supported by the National Research and Development Project of China(Grant Nos.2021YFC0863300,2020YFA0707500,2018YFA0900801);the CAMS Initiative for Innovative Medicine of China(Grant No.2021-I2M-1-035);the Strategic Priority Research Program(XDB29010000,XDB37030000),CAS(YSBR-010);the Special Funds of the National Natural Science Foundation of China(Grant Nos.82061138007 and 92169210);Xiangxi Wang was supported by the Ten Thousand Talent Program and the NSFS Innovative Research Group(No.81921005).
Variants of concern(VOCs)like Delta and Omicron,harbor a high number of mutations,which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies(NAbs).In this study,Rhesus macaques immunize...
关键词：NEUTRAL HARBOR OMI 
Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination
《Signal Transduction and Targeted Therapy》2022年第5期1831-1841,共11页Xiangyang Chi Yingying Guo Guanying Zhang Hancong Sun Jun Zhang Min Li Zhengshan Chen Jin Han Yuanyuan Zhang Xinghai Zhang Pengfei Fan Zhe Zhang Busen Wang Xiaodong Zai Xuelian Han Meng Hao Ting Fang Jinghan Xu Shipo Wu Yi Chen Yingying Fang Yunzhu Dong Bingjie Sun Jinlong Zhang Jianmin Li Guangyu Zhao Changming Yu Qiang Zhou Wei Chen 
We thank the cryo-EM facility and the High-Performance Computing Center of Westlake University for providing technical support.We thank the Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,China,for providing the SARS-CoV-2.This research was supported by grants from the National Natural Science Foundation of China(projects 32022037,81803429);the Young Elite Scientists Sponsorship Program by CAST,the Leading Innovative and Entrepreneur Team Introduction Program of Hangzhou,the Special Research Program of Novel Coronavirus Pneumonia of Westlake University and Tencent Foundation.
The SARS-CoV-2 Omicron variant shows substantial resistance to neutralization by infection-and vaccination-induced antibodies,highlighting the demands for research on the continuing discovery of broadly neutralizing a...
关键词：NEUTRAL VACCINATION OMI 
SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis被引量：4
《Signal Transduction and Targeted Therapy》2022年第4期964-966,共3页Yanan Zhang Ting Zhang Yihui Fang Jie Liu Qinong Ye Lihua Ding 
the National Key Research and Development Program of China(2017YFA0505602);the National Natural Science Foundation(81930078,81872246,81802756,31470773 and 81773135);Military Medical Innovation Project(18CXZ047).
Dear Editor,The SARS-CoV-2 Omicron variant has rapidly displaced the Delta variant and spread across the world.The Omicron variant harbors over 60 mutations,and 15 of the mutations are located in the receptor-binding ...
关键词：HARBOR OMI patients 
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