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作品数：178被引量：448H指数：10
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Rapid Identification of Cryptococcus Organisms Easily Possible with Stimulated Raman Histology on a Pulmonary Tiny Biopsy Specimen: A Case Report
《Case Reports in Clinical Medicine》2025年第2期80-85,共6页Howard D. Epstein Cory D. Sessum Christian Freudiger Steven Pastore Javier A. Longoria 
Background: Cryptococcus neoformans is an opportunistic fungal pathogen that primarily affects immunocompromised individuals. While traditional histologic methods such as hematoxylin and eosin (H&E) staining can somet...
关键词：Rapid OnSite Assessment (ROSE) FNA CRYPTOCOCCUS Fungal Infection Diagnosis SRH HISTOLOGY 
Fully automated in vivo screening system for multi-organ imaging and pharmaceutical evaluation
《Microsystems & Nanoengineering》2025年第1期301-311,共11页Junhan Duan Guanming Lin Kangjian Jiao Xiaohui Hong Xudong Lin 
supported by the National Natural Science Foundation of China(82372088);the National Natural Science Foundation of Guangdong Province(2021A1515010266);the Shenzhen Science and Technology Program(202206193000001,20220816161126002);the Foundation of Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument(2020B1212060077);2021 Foshan Science and Technology Innovation Team for Young-Top Talents(2120001010795).
Advancements in screening technologies employing small organisms have enabled deep profiling of compounds in vivo.However,current strategies for phenotyping of behaving animals,such as zebrafish,typically involve tedi...
关键词：small organisms automated vivo screening system screening technologies microfluidic technology deep profiling compounds precise flui evaluation biological responses automated vivo screening system aiss 
Bioengineered therapeutic systems for improving antitumor immunity
《National Science Review》2025年第1期317-339,共23页Ying Cao Wenlu Yan Wenzhe Yi Qi Yin Yaping Li 
supported by the National Key R&D Program of China(2022YFC3401400);the National Natural Science Foundation of China(32130058,32171315 and 31930066);the Shandong Provincial Natural Science Foundation(ZR2019ZD25);the Shandong Laboratory Program(SYS202205).
Immunotherapy,a monumental advancement in antitumor therapy,sti l l yields limited clinical benefits owing to its unguaranteed efficacy and safety.Therapeutic systems derived from cellular,bacterial and viral sources ...
关键词：IMMUNOTHERAPY biological organisms gene engineering synthetic biology surface engineering 
In situ imaging of microplastics in living organisms based on mass spectrometry technology
《Eco-Environment & Health》2024年第4期412-417,共6页Ye Li Xiaoyu Sha Yuan Wang Yanfang Zhao Junje Zhang Ping Wang Xiangfeng Chen Baoshan Xing Lei Wang 
funded by the National Natural Science Foundation of China (42077336);the Asia-Pacific Network for Global Change Research (CRRP2019-FP06-WANG);the 111 Program of the Ministry of Education of China (T2017002);Tianjin Research Innovation Project for Postgraduate Students (2021YJSB042).
Plastic pollution is widely present in terrestrial and aquatic ecosystems,and microplastics(MPs)can be detected in organisms.In situ detection methods for MPs in organisms have attracted widespread attention.Tradition...
关键词：Microplastics ORGANISMS In situ imaging Mass spectrometry imaging 
Promises and challenges in inferring the evolution of ancient organisms using optimum growth temperature
《Science China Earth Sciences》2024年第12期3960-3962,共3页Wenkai TENG Chuanlun ZHANG 
supported by the National Natural Science Foundation of China(Grant Nos.92351301&32393974)。
Scientists from both life and earth sciences have invested generous efforts to investigate the evolutionary history and mechanism of microorganisms in deep time.One of the promising efforts may be inferring the optimu...
关键词：OPTIMUM PROMISE LIFE 
Recent Advances of Bioactive Marine Natural Products in Drug Discovery
《Journal of Ocean University of China》2024年第5期1297-1318,共22页ZHANG Qun LV Liuxia WANG Wenhui WEI Meiyan GU Yucheng SHAO Changlun 
supported by the Shandong Province Special Fund ‘Frontier Technology and Free Exploration’ from Laoshan Laboratory (No. 8-01);the National Natural Science Foundation of China (No. 42376116);the Special Funds of Shandong Province for Qingdao National Laboratory of Marine Science and Technology (No. 2022QN LM030003);the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University (No. CMEMR2023-B16);the National Key Research and Development Program of China (No. 2022YFC2601305);the Innovation Center for Academicians of Hainan Province, and the Fundamental Research Funds for the Central Universities (No. 202461059)
Marine natural products(MNPs)are valuable resources for drug development.To date,17 drugs from marine sources are in clinical use,and 33 pharmaceutical compounds are in clinical trials.Presently the success of drug de...
关键词：marine medicinal organisms natural products marine drug discovery and optimization drug development 
Divergent changes in diversity and network complexity across different trophic-level organisms drive soil multifunctionality of fire-impacted subtropical forests
《Forest Ecosystems》2024年第5期697-707,共11页Luhong Zhou Shangshi Liu Debao Lin Hang-Wei Hu Ji-Zheng He 
financially supported by the National Natural Science Foundation of China(Nos.42377288,32201528);the Natural Science Foundation of Fujian Province(No.2021J05040).
Widespread forest fires pose significant challenges to the diverse communities of soil-dwelling organisms and the multiple ecosystem functions they support.However,whether the biodiversity and interactions of various ...
关键词：Invertebrates MICROORGANISM Multifunctionality PROTISTS Wildfire 
Epidemiology and Clonal Spread Evidence of Carbapenem-Resistant Organisms in the Center of Care and Protection of Orphaned Children, Vietnam
《Open Journal of Medical Microbiology》2024年第3期165-189,共25页Van Kim Nguyen Pirom Noisumdaeng Pol. Maj. Katiya Ivanovitch Stephen Baker Eugene Athan Stephanie Jones Le Thi Lan Larry Croft Yin Peng Lee Tara Cassidy Van Hung Tran Thi Hang Phan Huu Tinh Ho 
Objective: To determine the prevalence of colonization and transmission of carbapenem-resistant Gram-negative organisms in order to develop of an effective infection prevention program. Design: Cross-sectional study w...
关键词：Carbapenem-Resistant Organisms Contamination Hand Hygiene Whole Genome Sequencing Infection Prevention 
Expanding super-resolution imaging versatility in organisms with multi-confocal image scanning microscopy
《National Science Review》2024年第9期152-164,共13页Wei Ren Meiling Guan Qianxi Liang Meiqi Li Boya Jin Guangxing Duan Liya Zhang Xichuan Ge Hong Xu Yiwei Hou Baoxiang Gao Sodmergen Peng Xi 
supported by the National Key R&D Program of China(2022YFC3401100);the National Natural Science Foundation of China(62025501,31971376,92150301,62335008 and 62305004).
Resolving complex three-dimensional(3D)subcellular dynamics noninvasively in live tissues demands imaging tools that balance spatiotemporal resolution,field-of-view and phototoxicity.Image scanning microscopy(ISM),as ...
关键词：super-resolution imaging CONFOCAL image scanning microscopy 
The potential of biodeposition by filter-feeding organisms for microplastic remediation in natural waters
《Science Bulletin》2024年第15期2319-2322,共4页Liujiang Meng Xiaoxia Sun Shan Zheng 
supported by the National Natural Science Foundation of China (U2006206, 42006118);the International Science Partnership Program of the Chinese Academy of Sciences (121311KYSB20190029, 133137KYSB20200002)。
Global plastic production continues to grow as the production of various plastic products greatly facilitates daily life. Plastics are highly persistent in the environment due to their recalcitrant properties, and the...
关键词：eventually POTENTIAL CONTINUE 
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