云南高校图书馆联盟文献共享服务平台- OUABAIN

OUABAIN: 作品数：53被引量：118H指数：6; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：万艳苏萍娄欢洪兰刘光耀更多>>; 相关机构：华中科技大学延边大学第三军医大学大坪医院安徽省药物临床评价中心更多>>; 相关期刊：《Chinese Medical Journal》《哈尔滨医科大学学报》《中国循证儿科杂志》《Open Journal of Biophysics》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划江苏省“科教兴卫工程”医学重点人才基金更多>>

The Radioactive 45Ca Cannot Be Used for Adequate Estimation of the Functional Activity of 40Ca Ions in Cells and Organisms: 《Open Journal of Biophysics》2020年第1期13-26,共14页Anna Nikoghosyan Lilia Narinyan Armenuhi Heqimyan Sinerik Ayrapetyan; Previously we have shown that nM ouabain-induced activation of cAMP-dependent Na/Ca exchange in reverse (R) mode in cell membrane has age-dependent weakening hydration effect on heart muscle and brain tissues and such...; 关键词：Rat Brain Heart Muscle 45Ca Na/Ca Exchange OUABAIN

Ouabain impairs cancer metabolism and activates AMPK-Src signaling pathway in human cancer cell lines被引量：5: 《Acta Pharmacologica Sinica》2020年第1期110-118,共9页Jia-jia Shen Yue-chen Zhan Hui-ying Li Zhen Wang; the National Natural Science Foundation of China(81872286 and 81621064 to ZW);the CAMS Innovation Fund for Medical Sciences(2016-I2M-2-002 to ZW,2019-I2M-1-003 to JS);the CAMS Medical Epigenetics Research Center(2018PT31030 to ZW);the Drug Innovation Major Project(2018ZX09711001-003-006 to ZW).; In addition to the well-known cardiotonic effects,cardiac glycosides(CGs)produce potent anticancer effects with various molecular mechanisms.We previously show that ouabain induces autophagic cell death in human lung ...; 关键词：OUABAIN AMPK SRC CANCER oxidative phosphorylation GLYCOLYSIS

Aging Leads to Over-Expression of Na+/K+Pump Units in Liver and Na+/Ca2+Exchangers in Brain Cortex被引量：1: 《Open Journal of Biophysics》2019年第3期218-237,共20页Anna Nikoghosyan Armenuhi Heqimyan Sinerik Ayrapetyan; The metabolic controlling of tissue hydration is the fundamental parameter determining cell functional activity and its dysfunction is the common consequence of any cell pathology, including aging. The aim of the pres...; 关键词：Rat Hydration Brain Cortex LIVER Spleen [3H]-Ouabain

The Quantum-Mechanical Sensitivity of Cell Hydration in Mammals: 《Open Journal of Biophysics》2018年第3期104-116,共13页Anna Nikoghosyan Lilia Narinyan Armenuhi Heqimyan Sinerik Ayrapetyan; The elucidation of the mechanism on the biological effects of weak chemical and physical factors on cells and organism is one of the modern problems in life sciences. According to the Receptor Theory of Prof. Bernard ...; 关键词：RAT HYDRATION OUABAIN

Ouabain inhibits anchorage-independent growth in human lung cancer cells via integrinαvβ3 reduction: 《Asian Journal of Pharmaceutical Sciences》2016年第1期189-190,共2页Chuanpit Ninsontia Varisa Pongrakhananon Chatchai Chaotham Pithi Chanvorachote; Physiological effects of ouabain (Fig. 1A), a human endogenous hormone, have been intensively investigated nowadays.Recent studies demonstrate anticancer activity of ouabain in sensitization of apoptosis and suppressi...; 关键词：OUABAIN Anchorage-independent growth LUNG cancer cells Integrinαvβ3 REDUCTION

Proliferating cell nuclear antigen involved in the repair process of ouabain-induced brain damage independent of hypertension in rats: 《Chinese Medical Journal》2014年第11期2111-2116,共6页You Beian Shen Lin Qiu Jie Liu Xiangju Zhao Shaohua Ji Xiang Wang Yan Gao Haiqing; This work was supported by grants from the National Natural Science Foundation of China （No.30700884,30873145） and the Key Science and Technology Project of Shandong Province （No.2010GGC10294,BS2009SW015,2012GSF12122）.Acknowledgments： We would like to thank Professor Yan Lee of University of Pennsylvania for her work in revising our paper.; Background Ouabain is a mammalian adrenocortical hormone that is involved in the pathogenesis of hypertension by inhibiting Na-K ATPase activity.It also participates in a variety of kinase-mediated signaling pathways ...; 关键词：OUABAIN proliferating cell nuclear antigen HYPERTENSION brain Na-K ATPase

Effect of ouabain on the pathogenesis of hypertension in rats被引量：1: 《Chinese Medical Journal》2014年第10期1931-1934,共4页Liu Meiyan Ren Yanping Guo Chengjun; Background Ouabain and digoxin are important cardiac glycoside and related to many cardiovascular diseases.The purpose of this study was to investigate the changes of sodium pump α-subunit expression in rats and comp...; 关键词：OUABAIN DIGOXIN HYPERTENSION sodium pump α-subunit

Relationship between Ouabain and Asthenozoospermia被引量：1: 《Journal of Huazhong University of Science and Technology(Medical Sciences)》2014年第1期87-90,共4页杨宜红万艳娄欢薛婷苏萍; supported by 2012 Independence Innovation Foundation of Huazhong University of Science and Technology(No.01-18-519003); A growing number of researches have shown that ouabain can regulate mammalian sperm function and male reproduction by modulating the sperm motility, capacitation and acrosome reaction in vitro. This study further exam...; 关键词：OUABAIN ASTHENOZOOSPERMIA MOTILITY Na＋/K＋ATPase α4 isoform

Ouabain诱导沙鼠蜗外电诱发听性脑干反应变化研究: 《临床和实验医学杂志》2013年第18期1433-1436,1439,共5页王林娥张汝祥张道行; 首都医科大学基础与临床合作课题资助(10JL27); 目的沙鼠耳蜗圆窗应用毒毛旋花甙G(Ouabain),观察沙鼠蜗外电诱发听性脑干反应(EABR)的变化。方法显微镜下将浸有50μl Ouabain(1 mM)的明胶海绵置于沙鼠耳蜗圆窗膜表面,观察应用Ouabain 24 h、96 h后听觉脑干反应(ABR)、耳蜗微音电位(CM...; 关键词：毒毛旋花甙G（Ouabain）沙鼠电诱发听性脑干反应

不同浓度Ouabain对贵州小型猪内耳形态及听力的影响被引量：6: 《中华耳科学杂志》2013年第2期279-283,共5页张雪茹杨仕明李登科马玥莹赵立东郭维维邢光前; 国家973计划重大科学研究计划干细胞项目(2012CB967900);国家自然科学基金面上项目(81721082);国家973计划重大科学问题导向项目(2011CBA01000);江苏省"科教兴卫工程"医学重点人才基金(RC2077064); 目的探讨不同浓度ouabain溶液对贵州小型猪内耳的作用,分析听力改变与药物浓度关系。方法采用健康、黑色2月龄贵州小型猪13只,随机分为实验组、对照组和正常对照组,其中试验组动物通过完整圆窗膜局部应用不同浓度ouabain,分为1mM组、0....; 关键词：内耳毛细胞螺旋神经节听神经病动物模型

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