OXIDATIVE_STRESS

作品数：1723被引量：7239H指数：30
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N-acetylcysteine ameliorates erectile dysfunction in rats with hyperlipidemia by inhibiting oxidative stress and corpus cavernosum smooth muscle cells phenotypic modulation
《Asian Journal of Andrology》2024年第1期99-106,共8页Wei Ding Jun-Hong Fan Li-Ren Zhong Nan-Xiong Wang Lu-Hao Liu Hai-Bo Zhang Li Wang Ming-Qiang Wang Bing-Lin He An-Yang Wei 
This work is supported by a grant from the National Natural Science Foundation of China(No.82060809);the Natural Science Foundation of Guangdong Province(No.2017A030313453 and No.2018A030313638);Guangzhou Basic and Applied Basic Research Foundation(No.202102020417).
Hyperlipidemia is a major risk factor for erectile dysfunction(ED).Oxidative stress and phenotypic modulation of corpus cavernosum smooth muscle cells(CcSMCs)are the key pathological factors of ED.N-acetylcysteine(NAC...
关键词：erectile dysfunction HYPERLIPIDEMIA N-ACETYLCYSTEINE oxidative stress henotypic modulation 
Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway
《Asian Journal of Andrology》2024年第1期57-66,共10页Chang-Bo Zhao Wei-Bo Chen Wen-Zhen Wang Fang-Xin Gong Cui-Qin Fan Ye Li Tian Lan Wen-Jing Wang Ming-Zhen Yuan 
The Rongxiang Regenerative Medicine Foundation of Shandong University(No.2019SDRX-xx)supported this study.
The major vascular complications associated with diabetes make the management of diabetic mellitus erectile dysfunction(DMED)a challenging endeavor.Notable factors contributing to DMED include oxidative stress,nitric ...
关键词：APOPTOSIS diabetic mellitus erectile dysfunction nitro-oleic acid NO/cGMP pathway oxidative stress 
The protective effects and underlying mechanisms of dapagliflozin on diabetes-induced testicular dysfunction被引量：4
《Asian Journal of Andrology》2023年第3期331-338,共8页Zhi-Chao Luo Zi-Run Jin Ya-Fei Jiang Tian-Jiao Wei Ya-Lei Cao Zhe Zhang Rui Wei Hui Jiang 
This work was supported by the National Natural Science Foundation of China(81901535 and 82071698);the Natural Science Foundation of Beijing Municipality(7222208);the National Key Research&Developmental Program of China(2021YFC2700203).
Male diabetic individuals present a marked impairment in fertility;however,knowledge regarding the pathogenic mechanisms and therapeutic strategies is unsatisfactory.The new hypoglycemic drug dapagliflozin has shown c...
关键词：DAPAGLIFLOZIN diabetes glucagon-like peptide-1 receptor male infertility oxidative stress 
Bisphenol A induces testicular oxidative stress in mice leading to ferroptosis被引量：4
《Asian Journal of Andrology》2023年第3期375-381,共7页Li Li Min-Yan Wang Hua-Bo Jiang Chun-Rong Guo Xian-Dan Zhu Xia-Qin Yao Wei-Wei Zeng Yuan Zhao Ling-Kan Chi 
This work was supported by grant from the National Natural Science Foundation of China(No.8207152171 and No.82205166)。
Bisphenol A is a common environmental factor and endocrine disruptor that exerts a negative impact on male reproductive ability.By exploring bisphenol A-induced testicular cell death using the Institute of Cancer Rese...
关键词：bisphenol A ferroptosis mitochondrial damage oxidative stress testicular toxicity 
Glutathione S-transferase genetic polymorphisms and fluoride-induced reproductive toxicity in men with idiopathic infertility
《Asian Journal of Andrology》2023年第3期404-409,共6页Jun He Yi Mu Miao Liu Bang-Wei Che Wen-Jun Zhang Ke-Hang Chen Kai-Fa Tang 
This study was supported by the National Natural Science Foundation of China(No.81660263)and the Science and Technology Fund Project of Guizhou Health Commission(No.gzwkj2021-211).
Male infertility caused by idiopathic oligoasthenospermia(OAT)is known as idiopathic male infertility.Glutathione S-transferase(GST)and fluoride may play important roles in idiopathic male infertility,but their effect...
关键词：FLUORINE glutathione S-transferase idiopathic male infertility oxidative stress POLYMORPHISM 
Modulation of SIRT1 expression improves erectile function in aged rats
《Asian Journal of Andrology》2022年第6期666-670,共5页Wen Yu Jing Wang Yu-Tian Dai Bin Wang Yang Xu Qing-Qiang Gao Zhi-Peng Xu 
supported by the National Natural Science Foundation of China(No.81170563).
Silent information regulator 2-related enzyme 1(SIRT1)is an aging-related protein activated with aging.Herein,we evaluated the role of SIRT1 in aging-related erectile dysfunction.The expression of SIRT1 was modulated ...
关键词：apoptosis erectile function nitric oxide/cyclic guanosine monophosphate signaling oxidative stress SIRT1 expression 
Metabolic enzyme gene polymorphisms predict the effects of antioxidant treatment on idiopathic male infertility被引量：1
《Asian Journal of Andrology》2022年第4期430-435,共6页Hong-Yan Zhang Yi Mu Pan Chen Dong-Dong Liu Ke-Hang Chen Qi Yu Jun He Fa Sun Jun-Ping Xing Kai-Fa Tang 
supported by the National Natural Science Fund of China(No.81660263 and No.81300541);the China Postdo.ctoral Science Foundation(No.2015M582760XB);the Doctoral Fund of Affiliated Hospital of Guiyang Medical College(No.C-2012-6).
To explore the relationship between genetic polymorphisms of metabolic enzymes such as CYP1A1,CYP2D6,GSTM1,GSTT1,and GSTP1 and idiopathic male infertility.By observing the efficacy of antioxidants in the treatment of ...
关键词：GENE INFERTILITY metabolic enzyme oxidative stress POLYMORPHISMS 
Exploring the potential impact of nutritionally actionable genetic polymorphisms on idiopathic male infertility:a review of current evidence被引量：4
《Asian Journal of Andrology》2021年第5期441-449,共9页Sinda Mahbouli Charlotte Dupont Yaelle Elfassy Eric Lameignere Rachel Levy 
Infertility affects about 15%of the world's population.In 40%-50%of infertile couples,a male factor underlies the problem,but in about 50%of these cases,the etiology of male infertility remains unexplained.Some clinic...
关键词：energy metabolism genetic polymorphisms idiopathic male infertility lifestyle factors NUTRITION oxidative stress semen quality 
Use of a male antioxidant nutraceutical is associated with superior live birth rates during IVF treatment被引量：1
《Asian Journal of Andrology》2021年第1期16-23,共8页Kelton Tremellen Richard Woodman Amy Hill Helana Shehadeh Michelle Lane Deirdre Zander-Fox 
Oxidative stress is prevalent among infertile men and is a significant cause of sperm DNA damage.Since sperm DNA damage may reduce embryo quality and increase miscarriage rates,it is possible that untreated sperm oxid...
关键词：ANTIOXIDANT body mass index in vitro fertilization live birth oxidative stress SPERM 
Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice被引量：4
《Asian Journal of Andrology》2020年第6期590-601,共12页Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang 
This research was supported by the National Basic Research Program of China(Grant No.2014CB943103);National Natural Science Foundation of China(Grant No.31471104,No.31671203,No.31301225,No.31301226,No.31701119,and No.31571192)and was partly realized under the frame of the France-China scientific exchange programs"Xu Guangqi"and"Cai Yuanpei"of the"Partenariat Hubert CurienM attributed to J RD and YLZ The authors thank Prof.Winnie Wai Chi Shum,Prof.Xiaodong Sun,Ms.Aihua Liu,Dr.Chaobao Zhang,Dr.Zhen Lin,Dr.Xueting Luo,and the Bio-Med Big Data Center,CAS-MPG Partner Institute for Computational Biology,Shanghai Institutes for Biological Sciences,and Chinese Academy of Sciences for their kind support.
The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,...
关键词：EPIDIDYMIS GPX5 oxidative stress PIRNA PIWI-interacting RNA small noncoding RNA 
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