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Chemical exchange saturation transfer MRI for neurodegenerative diseases:An update on clinical and preclinical studies: 《Neural Regeneration Research》2026年第2期553-568,共16页Ahelijiang Saiyisan Shihao Zeng Huabin Zhang Ziyan Wang Jiawen Wang Pei Cai Jianpan Huang; supported by The University of Hong Kong,China(109000487,109001694,204610401,and 204610519);National Natural Science Foundation of China(82402225)(to JH).; Chemical exchange saturation transfer magnetic resonance imaging is an advanced imaging technique that enables the detection of compounds at low concentrations with high sensitivity and spatial resolution and has been...; 关键词：Alzheimer’s disease chemical exchange saturation transfer Huntington’s disease magnetic resonance imaging molecular imaging multiple sclerosis neurodegenerative disease Parkinson’s disease

ABCA5 lipid transporter is associated with a reduced risk of Parkinson’s disease: 《Neural Regeneration Research》2026年第2期669-670,共2页Jasmin Galper Nicolas Dzamko Woojin Scott Kim; A key pathological feature of Parkinson’s disease(PD)is that lysosomes are overwhelmed with cellular materials that need to be degraded and cleared.While the build-up of protein is characteristic of neurodegenerative...; 关键词：neurodegenerative diseases lipid transporter abca LYSOSOME protein build up Alzheimers disease cellular materials Parkinsons disease

Human stem cell-based cell replacement therapy for Parkinson’s disease:Enhancing the survival of postmitotic dopamine neuron grafts: 《Neural Regeneration Research》2026年第2期689-690,共2页Tae Wan Kim; supported by the DGIST start-up funds from the Ministry of Science and ICT(2024010330);a National Research Foundation of Korea(NRF)grant funded by the Korea Government(MSIT)(No.RS-2024-00351442)(to TWK).; Parkinson’s disease(PD)is the second most common neurodegenerative disorder.The progressive degeneration of dopamine(DA)producing neurons in the midbrain is the pathological hallmark,which leads to debilitating motor...; 关键词：neuronal survival cell replacement therapy dopamine neurons human stem cells bradykinesiadrug treatmentssuch Parkinsons disease neurodegenerative disorderthe parkinson s disease pd

Exosomes in neurodegenerative diseases:Therapeutic potential and modification methods: 《Neural Regeneration Research》2026年第2期478-490,共13页Hongli Chen Na Li Yuanhao Cai Chunyan Ma Yutong Ye Xinyu Shi Jun Guo Zhibo Han Yi Liu Xunbin Wei; supported by the National Natural Science Foundation of China,No.22103055(to JG);the Natural Science Foundation of Hebei Province,No.F2024110001(to HC);and Open Project of Tianjin Key Laboratory of Optoelectronic Detection Technology and System,Nos.2024LODTS215(to NL),2024LODTS216(to XS).; In recent years,exosomes have garnered extensive attention as therapeutic agents and early diagnostic markers in neurodegenerative disease research.Exosomes are small and can effectively cross the blood-brain barrier,...; 关键词：Alzheimer’s disease cell recognition central nervous system diseases enhanced targeting exosome modification exosome targeting neurodegenerative disease Parkinson’s disease stem cell exosomes stem cell therapy

Plasma circulating cell–free DNA integrity and relative telomere length as diagnostic biomarkers for Parkinson's disease and multiple system atrophy:a cross-sectional study: 《Neural Regeneration Research》2025年第12期3553-3563,共11页Chao Ying Chao Han Yuan Li Mingkai Zhang Shuying Xiao Lifang Zhao Hui Zhang Qian Yu Jing An Wei Mao Yanning Cai; supported by the National Key Research and Development Program of China,No.2021YFC2501205(to YC);the Science and Technology Innovation 2030 project,No.2021ZD0201101(to YC);the National Natural Science Foundation of China,Nos.82201409(to YL),82201401(to CH);the Xuanwu Youth Development Project,No.QNPY2021011(to CH)。; In clinical specialties focusing on neurological disorders,there is a need for comprehensive and integrated non-invasive,sensitive,and specific testing methods.Both Parkinson's disease and multiple system atrophy are ...; 关键词：biomarkers cell-free DNA diagnosis multiple system atrophy neurodegenerative diseases Parkinson’s disease risk factors

Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes:potential targets for neural repair in neurological diseases: 《Neural Regeneration Research》2025年第12期3349-3369,共21页Yichen Peng Li Zhou Yaju Jin Danli Wu Na Chen Chengcai Zhang Hongpeng Liu Chunlan Li Rong Ning Xichen Yang Qiuyue Mao Jiaxin Liu Pengyue Zhang; supported by Yunnan Province Innovation Team of Prevention and Treatment for Brain Disease with Acupuncture and Tuina,No.202405AS350007;Youth Top Talent Project of 10-thousand Talent Plan in Yunnan Province,No.YNWR-QNBJ-2018-345;the National Natural Science Foundation of China,No.81960731;Joint Special Project of Traditional Chinese Medicine in Science and Technology Department of Yunnan Province,Nos.2019FF002[-008],202001AZ070001-002 and 202001AZ070001-030;Yunnan Province University Innovation Team Projects No.2019YGC04;Yunnan Province Project Education Fund,Nos.2024Y406,2024Y414(all to PZ)。; The exchange of information and materials between organelles plays a crucial role in regulating cellular physiological functions and metabolic levels.Mitochondria-associated endoplasmic reticulum membranes serve as ph...; 关键词：Alzheimer’s disease amyotrophic lateral sclerosis Ca^(2+)signaling conduction Huntington’s disease ischemic stroke MAMMALS mitochondrial dynamics neural function repair oxidative stress Parkinson’s disease traumatic brain injury

Gut–brain axis and environmental factors in Parkinson's disease:bidirectional link between disease onset and progression: 《Neural Regeneration Research》2025年第12期3416-3429,共14页Soo Jung Park Kyung Won Kim Eun Jeong Lee; supported by the National Research Foundation(NRF)of Korea(2022R1C1C1005741 and RS-2023-00217595)。; Parkinson's disease has long been considered a disorder that primarily affects the brain,as it is defined by the dopaminergic neurodegeneration in the substantia nigra and the brain accumulation of Lewy bodies contain...; 关键词：gut inflammation gut microbiome gut-brain axis micro/nano-plastics Parkinson’s disease Α-SYNUCLEIN

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease: 《Neural Regeneration Research》2025年第10期2917-2918,共2页Leyre Ayerra Maria S.Aymerich; supported by the Spanish Government(ISCIII-FEDER)PI20/01063;by Navarra Government(PC 060-061 and PC 192-193);Fundación Gangoiti(to MSA).LA was funded by FPU19/03255.; Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss o...; 关键词：inflammation LEUKOCYTE generating

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease: 《Neural Regeneration Research》2025年第10期2998-3012,共15页Yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang; supported by the Science and Technology(S&T)Program of Hebei Province,No.22377798D(to YZ).; Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease progression.The proteins,DNA,mRNA,and lipids carried by exosomes reflect...; 关键词：biomarker diagnosis EXOSOMES N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease: 《Neural Regeneration Research》2025年第10期2855-2861,共7页Chanchal Sharma Sehwan Kim Hyemi Eo Sang Ryong Kim; supported by the National Research Foundation of Korea(RS-2023-00245298);the Korea Healthcare Technology R&D(HI21C1795)grants,funded by the Korean government(to SRK).; A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers neurodegeneration.While medications effectively manage symptoms,they offer no long-term benefit because they fail to ...; 关键词：adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

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