PARKINSON_DISEASE

作品数：125被引量：198H指数：7
导出分析报告
相关作者：余舒扬陈滢陈晓春王涛张巧俊更多>>
相关机构：首都医科大学附属北京天坛医院福建医科大学环境与疾病相关基因教育部重点实验室西安交通大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金北京市自然科学基金国家重点基础研究发展计划陕西省自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
选择条件：
  • 主题=Α-SYNUCLEINx
共 条 记 录，以下是1-6
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease被引量：2
《Translational Neurodegeneration》2022年第1期390-400,共11页Matilde Bongianni Mauro Catalan Daniela Perra Elena Fontana Francesco Janes Claudio Bertolotti Luca Sacchetto Stefano Capaldi Matteo Tagliapietra Paola Polverino Valentina Tommasini Giulia Bellavita Elham Ataie Kachoie Roberto Baruca Andrea Bernardini Mariarosaria Valente Michele Fiorini Erika Bronzato Stefano Tamburin Laura Bertolasi Lorenzo Brozzetti Maria Paola Cecchini Gianluigi Gigli Salvatore Monaco Paolo Manganotti Gianluigi Zanusso 
Fondazione Cariverona:“Development and validation of a novel molecular assay forα-synuclein in patients with Parkinson’s disease and otherα-synucleinopathies”#2018.0708 to GZ and Brain Research Verona Foundation to GZ.Dr.Elena Fontana is attending a doctoral fellowship supported by COPAN group.
Background: In patients with Parkinson’s disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate as in other α-synucle...
关键词：Parkinson disease ALPHA-SYNUCLEIN Real-time quaking-induced conversion assay Olfactory mucosa Cerebrospinal fluid 
Glutathione peroxidase 4 deficit-mediated fer⁃roptosis contributes to dopaminergic neuron degeneration under synucleinopathy
《中国药理学与毒理学杂志》2021年第9期645-646,共2页SUN Jie LU Dan-hua LI Kun LIN Xiao-min PAN Ming-hai GONG Hai-biao SUN Wan-yang WANG Meng LIANG Lei Kurihara Hiroshi LI Yi-fang DUAN Wen-jun ZHANG Li HE Rong-rong 
National Key Research and Development Program of China(2017YFC1700404);Natural Science Foundation of China(81873209);Natural Science Foundation of China(U1801284);Natural Science Foundation of China(81903821);Natural Science Foundation of China(81973718);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036);GDUPS(2019),Fun⁃damental Research Funds for the Central Univer⁃sities(21620448);Natural Science Foundation of Guangdong Province(2019A 1515010909);Nat⁃ural Science Foundation of Guangdong Prov⁃ince(2021A1515011297);Science and Tech⁃nology Program of Guangzhou(201903010062);Science and Technology Program of Guang⁃zhou(907158833068),and the Innovation Team Project of Guangdong Provincial Department of Education(2020KCXT D003)。
OBJECTIVE Intracellular aggre⁃gation ofα-synuclein(SNCA)is one of the core pathological features of neurodegenerative disor⁃ders including Parkinson disease,whilst the detailed mechanism for consequently neuron loss ...
关键词：Parkinson disease ferroptosis glutathione peroxidase-4 phospholipid-omics Α-SYNUCLEIN 
Tetramethylpyrazine analogue T-006 promotes clearance of alpha-synuclein by enhancing proteasome activity in Parkinson disease models被引量：1
《中国药理学与毒理学杂志》2019年第9期658-659,共2页ZHOU He-feng SHAO Min GUO Bao-jian LI Chu-wen LU Yu-cong YANG Xuan-jun LI Sheng-nan LI Hai-tao ZHU Qi ZHONG Han-bing WANG Yu-qiang ZHANG Zai-jun LU Jia-hong LEE Ming-yuen Simon 
Science and Technology Development Fund(FDCT)of Macao SAR(069/2015/A2;134/2014/A3;062-2017-AIR);Research Committee,University of Macao(MYRG2015-00182-ICMS-QRCM;MYRG2015-00214-ICMSQRCM;MYRG139(Y1-L4)-ICMS12-LMY;and MYRG2016-00129-ICMS-QRCM)
OBJECTIVE To investigate the effects of T-006(tetramethylpyrazine derivative)in promotingα-Synuclein(α-Syn)degradation and evaluated the neuroprotective effects in cellular and animalα-Syn model of Parkinson diseas...
关键词：Α-SYNUCLEIN degradation LMP7 proteasome activity Parkinson disease 
Reassessment subacute MPTP-treated mice model of Parkinson disease
《中国药理学与毒理学杂志》2017年第10期1024-1025,共2页Lu WEN Yu-he YUAN Nai-hong CHEN 
supported by National Natural Science Foundation of China(81373997,U1402221,81573640 and 81603316);Beijing Natural Science Foundation(7161011);Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150);CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-1-004);Key Research and Development Project of Hunan Province(2015SK2029-1);Scientific Research Foundation of the Higher Education Institutions of Hunan Province(15K091)
OBJECTIVE(1) To estimate the value of the subacute MPTP mouse model in aspects of behavioral performance,biochemical changes and pathological abnormalities.(2) To find effective positive drugs.METHODS Male C57 BL/6 mi...
关键词：subacute MPTP model Parkinson disease SELEGILINE PRAMIPEXOLE Α-SYNUCLEIN 
The biomarkers of immune dysregulation and inflammation response in Parkinson disease被引量：3
《Translational Neurodegeneration》2016年第1期131-136,共6页Li Chen Mingshu Mo Guangning Li Luan Cen Lei Wei Yousheng Xiao Xiang Chen Shaomin Li Xinling Yang Shaogang Qu Pingyi Xu 
This review was supported by research grants from the State Key Development Program for Basic Research of China(2011CB510000);the National Natural Science Foundation of China(81271428,81471292,U1503222 and 81430021);the keypoint Science Foundation of Guangdong of China(2015A030311021);a grant supported by technology project of Guangzhou(201604020152);a grant supported by assisting research project of science and technology for Xinjiang(201591160).
Parkinson’s disease(PD)is referring to the multi-systemicα-synucleinopathy with Lewy bodies deposited in midbrain.In ageing,the environmental and genetic factors work together and overactive major histocompatibility...
关键词：Parkinson’s disease α-synucleinopathy INFLAMMATION Biomarkers 
Alpha-synuclein and Parkinson disease被引量：2
《Neural Regeneration Research》2007年第4期239-243,共5页Hui Liu Xiaozhong Wang 
OBJECTIVE： To review the recent progresses on the studies of α -synuclein in the pathogenesis of Parkinson disease （PD） and look into the perspective of α -synuclein as a new therapy target. DATA SOURCES： To sea...
关键词：Α-SYNUCLEIN Parkinson＇s disease Lewy＇s body 
全选清除导出
共1页<1>
检索报告 对象比较 聚类工具 使用帮助 返回顶部