SELEGILINE

作品数：8被引量：39H指数：3
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相关领域：医药卫生更多>>
相关作者：崔凯荣王杉吴侔天吴蔚然王仁刚更多>>
相关机构：国家体育总局中国科学院上海生命科学研究院中山大学附属第一医院更多>>
相关期刊：《质谱学报》《Acta Pharmacologica Sinica》《Chinese Medical Journal》《Advances in Parkinson's Disease》更多>>
相关基金：北京市自然科学基金国家自然科学基金更多>>
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Type-B monoamine oxidase inhibitors in neurological diseases:clinical applications based on preclinical findings被引量：3
《Neural Regeneration Research》2024年第1期16-21,共6页Marika Alborghetti Edoardo Bianchini Lanfranco De Carolis Silvia Galli Francesco E.Pontieri Domiziana Rinaldi 
Type-B monoamine oxidase inhibitors,encompassing selegiline,rasagiline,and safinamide,are available to treat Parkinson's disease.These drugs ameliorate motor symptoms and improve motor fluctuation in the advanced stag...
关键词：glial cell line-derived neurotrophic factor(GDNF) GLUTAMATE neurological disorders NEUROPROTECTION Parkinson's disease preclinical studies RASAGILINE SAFINAMIDE SELEGILINE type-B monoamine oxidase(MAO_(B))inhibitors 
Selegiline improves excessive daytime sleepiness in Parkinson’s disease:an open-label observational study
《Chinese Medical Journal》2022年第14期1762-1764,共3页Jinru Zhang Juping Chen Jia Li Jian Li Hong Miao Xiangyang Zhu Meng Meng Yang Han Jing Chen Xiaoyu Cheng Kangping Xiong Hong Jin Weifeng Luo Chengjie Mao Chunfeng Liu 
supported by grants from Jiangsu Provincial Key R&D Program(BE2018658);Suzhou Science and Technology Development Plan(Minsheng Science and Technology)(SKJY2021089);Discipline Construction Program of the Second Affiliated Hospital of Soochow University(XKTJ-XK202001);Gusu Health Talents Plan(GSWS2020035,GSWS2019041).
To the Editor:Parkinson’s disease(PD)is the second most common neurodegenerative disorder,and sleep disturbance is a major disabling non-motor symptom.[1]Excessive daytime sleepiness(EDS)is defined as inappropriate a...
关键词：SLEEP driving PATIENTS 
Reassessment subacute MPTP-treated mice model of Parkinson disease
《中国药理学与毒理学杂志》2017年第10期1024-1025,共2页Lu WEN Yu-he YUAN Nai-hong CHEN 
supported by National Natural Science Foundation of China(81373997,U1402221,81573640 and 81603316);Beijing Natural Science Foundation(7161011);Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150);CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-1-004);Key Research and Development Project of Hunan Province(2015SK2029-1);Scientific Research Foundation of the Higher Education Institutions of Hunan Province(15K091)
OBJECTIVE(1) To estimate the value of the subacute MPTP mouse model in aspects of behavioral performance,biochemical changes and pathological abnormalities.(2) To find effective positive drugs.METHODS Male C57 BL/6 mi...
关键词：subacute MPTP model Parkinson disease SELEGILINE PRAMIPEXOLE Α-SYNUCLEIN 
Reassessment of subacute MPTP-treated mice as animal model of Parkinson＇s disease被引量：26
《Acta Pharmacologica Sinica》2017年第10期1317-1328,共12页Qiu-shuang ZHANG Yang HENG Zheng MOU Ju-yang HUANG Yu-he YUAN Nai-hong CHEN 
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine （MPTP） mouse model remains the most commonly used animal model of Parkinson＇s disease （PD）. There are three MPTP-treatment schemes： acute, subacute and chronic. Consi...
关键词：Parkinson＇s disease MPTP model SELEGILINE PRAMIPEXOLE medopar behavioral compensation ASTROCYTES Α-SYNUCLEIN blood brain＂barrier myelin sheath 
Quantitative EEG Changes in Patients with Parkinson’s Disease during Therapy with Rasagiline
《Advances in Parkinson's Disease》2014年第3期22-34,共13页Wilfried Dimpfel Christian Oehlwein Josef Anton Hoffmann Thomas Müller 
It has been suggested that in patients with Parkinson’s disease (PD) metabolism of the MAO-B inhibitor selegiline to methamphetamine may contribute and/or exacerbate sleep problems, possibly leading to deficits of co...
关键词：RASAGILINE SELEGILINE Quantitative EEG CATEEM^(■) Parkinson’s Disease COGNITION 
Monoamine oxidase-B (MAO-B) inhibitors: implications for disease-modification in Parkinson’s disease被引量：6
《Translational Neurodegeneration》2013年第1期124-133,共10页Kay Cheong Teo Shu-Leong Ho 
The authors’work is supported by the Henry G Leong Endowed Professorship;the Donation Fund for Neurology Research,University of Hong Kong.
There is a substantial amount of evidence from experimental parkinsonian models to show the neuroprotective effects of monoamine oxidase-B(MAOB)inhibitors.They have been studied for their potential disease-modifying e...
关键词：Parkinson's disease Monoamine oxidase-B inhibitors Disease-modification Neuroprotection SELEGILINE RASAGILINE 
用GC、GC/MS方法检测人尿中Selegiline及其代谢物被引量：3
《质谱学报》2000年第2期19-26,共8页崔凯荣 王杉 吴侔天 
本文采用 GC、GC/MS技术对口服 Selegiline Hydrochloride,一种单胺氧化酶抑制剂的尿中代谢物进行分析测定 ,确认检出 1 0种代谢产物 ,其中三种为新检测到的羟基化代谢物。
关键词：兴奋剂 SELEGILINE GC/MS 检测 尿样 代谢物 
Neuroprotective rather than neurorescue or neurorestorative effect of selegiline against MPTP-induced dopaminergic toxicity被引量：1
《中国药理学报》1999年第2期145-150,共6页吴蔚然 朱兴族 管瀚俊 王仁刚 季新泉 
目的：研究司来吉兰（ｓｅｌｅｇｉｌｉｎｅ，Ｓｅｌ）的神经保护作用及其对单胺氧化酶Ｂ（ＭＡＯＢ）的抑制作用．方法：高效液相电化学检测法测定小鼠纹状体内多巴胺（ＤＡ）及其代谢产物的含量．荧光检测法测定小鼠脑ＭＡＯＢ...
关键词：司来吉兰 多巴胺 纹状体 药理学 神经保护作用 
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