Pramipexole is a dopamine agonist used in the treatment of Parkinson’s disease and Restless legs syndrome. Although off-label, the use of Pramipexole as an adjunct therapy in treatment resistant depression has recent...
This work was supported by grants from the National Natural Science Foundation of China (81671250,82071420,82101333,81870997,82171251);Jiangsu Provincial Key R&D Program (BE2018658);the Key Project of Natural Science Foundation of Jiangsu Provincial Higher Education Institutions (21KJA180003);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
Inflammation is one of the pathogenic processes in Parkinson’s disease(PD).Dopamine receptor agonist pramipexole(PPX)is extensively used for PD treatment in clinics.A number of studies show that PPX exerts neuroprote...
supported by grants from Programa de Pos-graduacao em Neurociencias(PGN),Programa INCT-INOVAMED(grant No.465430/2014-7);Fundacao de Apoio à Pesquisa e Inovacao do Estado de Santa Catarina(FAPESC);Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES)。
Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in bio...
Non-ergot dopamine agonists have become popular for treating motor complications associated with long-term use of levodopa-containing drugs. We conducted a retrospective study in which we identified clinical problems ...
Parkinson’s disease is a common condition usually treated by dopaminergic agents and many behavioral abnormalities such as impulse control disorders (ICD) are connected with that usage. Pathological gambling, a form ...
supported by National Natural Science Foundation of China(81373997,U1402221,81573640 and 81603316);Beijing Natural Science Foundation(7161011);Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150);CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-1-004);Key Research and Development Project of Hunan Province(2015SK2029-1);Scientific Research Foundation of the Higher Education Institutions of Hunan Province(15K091)
OBJECTIVE(1) To estimate the value of the subacute MPTP mouse model in aspects of behavioral performance,biochemical changes and pathological abnormalities.(2) To find effective positive drugs.METHODS Male C57 BL/6 mi...
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model remains the most commonly used animal model of Parkinson's disease (PD). There are three MPTP-treatment schemes: acute, subacute and chronic. Consi...
A randomized, double blind, and active reference-controlled study was carried out among 116 patients suffering from idiopathic Parkinson’s disease (PD). The aim of the study was to compare the safety and efficacy of ...
Background: Drug adherence decreased in patients with Parkinson’ s disease (PD) because of taking many different types of drugs. We evaluated drug adherence after switching from immediate-release (IR) to once-daily e...
Background: Apathy occurs frequently in patients with Parkinson’s disease (PD), and has a negative impact on activities of daily living through loss of motivation. Pramipexole (PPX), which shows preferential affinity...