RESERPINE

作品数：24被引量：74H指数：5
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相关领域：医药卫生更多>>
相关作者：林浩然李智敏金航刘锡葵饶高雄更多>>
相关机构：中山大学云南省农业科学院中国科学院阿尔伯塔大学更多>>
相关期刊：《Journal of Behavioral and Brain Science》《水生生物学报》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》更多>>
相关基金：中国科学院科学基金军队科研计划项目云南省自然科学基金中国博士后科学基金更多>>
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Botulinum neurotoxin A ameliorates depressive-like behavior in a reserpine-induced Parkinson’s disease mouse model via suppressing hippocampal microglial engulfment and neuroinflammation被引量：1
《Acta Pharmacologica Sinica》2023年第7期1322-1336,共15页Yang Li Qiao Yin Qi Li An-ran Huo Ting-ting Shen Jia-qian Cao Chun-feng Liu Tong Liu Wei-feng Luo Qi-fei Cong 
the National Natural Science Foundation of China(32200778);Natural Science Foundation of Jiangsu Province(BK20220494);Suzhou Medical and Health Technology Innovation Project(SKY2022107);startup funding[NH21500221],[NH21500122];research funding by the Clinical Research Center of Neurological Disease in The Second Affliated Hospital of Soochow University[ND2022A04]to Qi fei Cong;the Suzhou Science and Technology Plan Key Technology Application Research Project[SS2019060];the National Natural Science Foundation of China[No.81671270];the Suzhou Clinical Research Center of Neurological Disease[SZZX201503];the Natural Science Foundation of Jiangsu Province of China[BK2011294]to Wei-feng Luo;the Priority Academic Program Development of Jiangsu Higher Education Institutes(PAPD)to Chun-feng Liu.
Depression is one of the common non-motor symptoms of Parkinson’s disease(PD).In the clinic,botulinum neurotoxin A(BoNT/A)has been used to treat depression.In this study,we investigated the mechanisms underlying the ...
关键词：Parkinson’s disease depression RESERPINE botulinum neurotoxin A microglia COMPLEMENT 
Pramipexole, a dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice被引量：3
《Neural Regeneration Research》2022年第2期450-458,共9页Carlos Pereira Martins Rodrigo Sebben Paes Gabriela Mantovani Baldasso Eduarda Gomes Ferrarini Rahisa Scussel Rubya Pereira Zaccaron Ricardo Andrez Machado-de-Avila Paulo Cesar Lock Silveira Rafael Cypriano Dutra 
supported by grants from Programa de Pos-graduacao em Neurociencias(PGN),Programa INCT-INOVAMED(grant No.465430/2014-7);Fundacao de Apoio à Pesquisa e Inovacao do Estado de Santa Catarina(FAPESC);Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES)。
Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in bio...
关键词：DOPAMINE dopaminergic system FIBROMYALGIA HYPERALGESIA pain PRAMIPEXOLE RESERPINE 
Reserpine-Induced Progressive Parkinsonism in Mice Predisposed and Non-Predisposed to Depressive-Like Behavior
《Journal of Behavioral and Brain Science》2021年第11期267-279,共13页Manuela B. L. Soares Leonardo B. Lopes-Silva Marcela Becegato Vinicius S. Bioni Alvaro C. Lima Gabriela M. Ferreira Ywlliane Meurer Regina H. Silva 
Parkinson’s disease (PD) is a progressive degenerative condition that mainly affects the elderly. The disease comprises motor symptoms such as tremors at rest, loss of voluntary movement, decreased muscle strength, p...
关键词：Parkinson’s Disease DEPRESSION RESERPINE MICE 
Epalrestat improves motor symptoms by reducing oxidative stress and inflammation in the reserpine induced mouse model of Parkinson’s disease被引量：6
《Animal Models and Experimental Medicine》2020年第1期9-21,共13页Md.Mahbubur Rahman Rupali Rani Chakraborti Md.Abdullah Potol Ariful Haque Abir Ozayra Sharmin Mahabub Alam Md.Fazlur Rahman Khan Rownock Afrin Humayra Jannat Rasiqh Wadud Zaki Farhad Habib 
We thank Ms Fahmida Zaman for her initial intellectual support for this project;We are grateful to Ms Noshin Noorjahan for her editorial support for our manuscript.Department of Pharmaceutical Sciences at North South University provided the Laboratory space,including the equipment and basic reagents necessary to conduct this project.
Background:Parkinson's disease(PD)is a progressive neurodegenerative disorder affecting a large number of elderly people worldwide.The current therapies for PD are symptom-based;they do not provide a cure but improve ...
关键词：BRADYKINESIA EPALRESTAT GLUTATHIONE OXIDATIVE-STRESS Parkinson's disease 
No association between low-dose reserpine use and depression in older hypertensive patient: result of a multicenter, cross-sectional study被引量：11
《Journal of Geriatric Cardiology》2019年第8期608-613,共6页Guo-Hua ZHU Xi-Peng SUN Jing LI Lin PI Hai-Qin TANG Hai-Qing GAO Hong-Liang CONG Peng QU Xin-Zheng LU Xin-Jun ZHANG Luo-Sha ZHAO Yi-Fang GUO Dong-Xia LIU Liang-Qing ZHANG Hua TANG Yi-Xin HU Li FAN Qi HUA 
Background Reserpine is currently used by millions of Chinese hypertensive patients, in spite of the continued concern of its depressogenic effect, even when used in low dose. This study aimed to investigate the assoc...
关键词：DEPRESSION Hypertension RESERPINE 
Crystal structures of MdfA complexed with acetylcholine and inhibitor reserpine
《Biophysics Reports》2016年第2期78-85,共8页Ming Liu lie Heng Yuan Gao Xianping Wang 
The DHA12 family of transporters contains a number of prokaryotic and eukaryote membrane proteins. Some of these proteins share conserved sites intrinsic to substrate recognition, structural stabilization and conforma...
关键词：MdfA RESERPINE DHA12 ANTIPORTER ACETYLCHOLINE 
Reserpine Improves Working Memory
《Journal of Behavioral and Brain Science》2016年第3期107-112,共6页Raghuraman Vasantharaja Ajeet Kumar Ashok Kumar Jamuna R. Subramaniam 
Despite exhaustive search, no drug is in sight for AD. Earlier, we reported that reserpine, an antihypertensive and antipsychotic drug, ameliorates Amyloid beta (Aβ-AD causing peptide) toxicity and confers several po...
关键词：Alzheimer’s Disease Amyloid-β-Aβ RESERPINE Cognitive Deficits Transgenic Mice Working Memory 
The features of reserpine-induced gastric mucosal lesions被引量：2
《Acta Pharmacologica Sinica》2010年第8期938-943,共6页Xiu-juan MA Guo-cai LU Shu-wei SONG Wei LIU Zhi-peng WEN Xiang ZHENG Qian-zhou LU Ding-feng SU 
Acknowledgements This study was supported by grants from the National Science and Technology Major Project （No 2009ZX09303-002）, the China Postdoctoral Science Foundation Funded Project （No 20080441303） and the Shanghai Postdoctoral Sustentation Fund （No 08R214101）.
Aim： To reinvestigate the characteristics of reserpine-induced gastric mucosal lesions （GMLs）. Methods： The GML-inducing effect of reserpine and the time-course of recovery from reserpine-induced GMLs were examine...
关键词：RESERPINE gastric mucosal lesions VAGOTOMY time course of recovery from gastric lesions compound hypotensive tablets 
利血平(Reserpine)药物资源研究与开发现状被引量：9
《云南中医学院学报》2008年第2期65-67,共3页李智敏 张慧颖 尹华琳 金航 刘锡葵 饶高雄 
云南省自然科学基金项目(No:2006C0010Z)
关键词：利血平 萝芙木 资源开发 种植规划 
The expression of adrenomedullin in rats adrenal medulla hyperplasia induced by reserpine and its significance
《China Medical Abstracts》2007年第2期144-145,共2页张孝斌 
Objective To observe adrenomedullin （ADM） in adrenal tissue and plasma of rats with adrenal medulla hyperplasia induced by reserpine and study its significance.Methods Thirty male Wistar rats were randomly divided i...
关键词：肾上腺增生 症状 临床表现 治疗方法 
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