ANTIPORTER

作品数：21被引量：143H指数：8
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相关领域：生物学农业科学更多>>
相关作者：张振华宋海星周婷廖琼王法龙更多>>
相关机构：东北师范大学湖南农业大学中国农业科学院植物保护研究所南京师范大学更多>>
相关期刊：《Biophysics Reports》《Horticulture Research》《农业生物技术学报》《Molecular Plant》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划更多>>
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A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy被引量：1
《Chinese Chemical Letters》2024年第2期295-299,共5页Qi Fu Zhongming Lian Mengya Niu Yaru Huang Yanqiu Ai Long He Dandan Zhang Cuixia Zheng Jian-Jun Yang Lei Wang Dandan Tian 
financially supported by the National Natural Science Foundation of China(No.82001189);The Project Tackling of Key Scientific and Technical Problems of Henan Provine(No.232102311163).
Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and survival.The concurrent treatmen...
关键词：Breast cancer bone metastasis Cancer-induced bone pain Cystine/glutamate antiporter SORAFENIB Photodynamic therapy 
High-level production of𝛾γ-aminobutyric acid via efficient co-expression of the key genes of glutamate decarboxylase system in Escherichia coli
《Engineering Microbiology》2023年第2期65-71,共7页Lili Yao Changjiang Lyu Yuting Wang Sheng Hu Weirui Zhao Hongwei Cao Jun Huang Lehe Mei 
This work was supported by Natural Science Foundation of Zhe-jiang Province(LY23B060001);Zhejiang Provincial Key R&D Pro-gram of China(2021C02049);China Postdoctoral Science Founda-tion(2020M671337);National Natural Science Foundation of China(31670804,31971372);Ningbo"Scientific and Technological In-novation 2025″Key Project(2020Z080,2020Z088).
Biosynthesis of the functional factor𝛾γ-aminobutyric acid(GABA)in bacteria involves two key proteins an intra-cellular glutamate decarboxylase(GadB)and a membrane-bound antiporter(GadC).Efficient co-expression of su...
关键词：Glutamate decarboxylase ANTIPORTER γ-Aminobutyric acid E.COLI Whole-cell biocatalysts 
DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease被引量：9
《Neural Regeneration Research》2023年第1期194-199,共6页Chun-Bo Hu Hui Jiang Yin Yang Guo-Hua Wang Qiu-Hong Ji Zhong-Zheng Jia Li-Hua Shen Qian-Qian Luo 
funded by the National Natural Science Foundation of China, No. 81873924 (to QQL), No. 82171190 (to GHW);Nantong Science and Technology Project of China, No. MS22021010 (to LHS);High-level Innovation and Entrepreneurship Talents Introduction Program of Jiangsu Province of China (to QQL)
DL-3-n-butylphthalide(NBP)-a compound isolated from Apium graveolens seeds-is protective against brain ischemia via various mechanisms in humans and has been approved for treatment of acute ischemic stroke.NBP has sho...
关键词：cystine/glutamate antiporter solute carrier family 7 member 11 DL-3-n-butylphthalide ferritin light chain ferroportin 1 ferroptosis glutathione peroxidase 4 oxidative stress iron ROTENONE transferrin receptor 
Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration被引量：16
《Translational Neurodegeneration》2022年第1期917-930,共14页Manish Verma Britney N.Lizama Charleen T.Chu 
Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system,acting to mediate excitatory neurotransmission.However,high levels of glutamatergic input elicit excitotoxicity,contribut...
关键词：Mitochondrial calcium Mitochondrial calcium uniporter NCLX antiporter Parkinson’s disease Alzheimer’s disease LRRK2 PINK1 BETA-AMYLOID MITOPHAGY EXCITOTOXICITY Amyotrophic lateral sclerosis Huntington’s disease GLUCOCEREBROSIDASE 
Functional characterization of a novel, highly expressed ion-driven sugar antiporter in the thoracic muscles of Helicoverpa armigera
《Insect Science》2022年第1期78-90,共13页Yi-Yang Yuan Yu-Cui Xin Jian-Li Han Yu-Han Zhao Shi-Ming Han Zi-Yan Nangong Xin Chen Zhu-Cheng Wang Mei Li Xing-Hui Qiu 
This work is supported by grants from National Natural Science Foundation of China(grant numbers 31601644 and 31970453);the State Key Laboratory of Integrated Management of Pest Insects and Rodents(grant numbers ChineselPM 1607 and ChineselPMl717).
Sugar transporters(STs),which mainly mediate cellular sugar exchanges,play critical physiological roles in living organisms,and they may be responsible for sugar exchanges among various insect tissues.However,the mole...
关键词：CRISPR/Cas9 GLUCOSE Helicoverpa armigera sugar transporter TREHALOSE thoracic muscles 
Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H^(+)-ATPase and Na^(+)/H^(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress被引量：14
《Molecular Plant》2021年第12期2000-2014,共15页Yongqing Yang Xiuli Han Liang Ma Yujiao Wu Xiao Liu Haiqi Fu Guoyong Liu Xiaoguang Lei Yan Guo 
supported by grants ofrom the National Natural Science Foundation of China(31430012,31872659,32070301,U1706201,31921001,31861133005,21625201,21961142010,21661140001,91853202,and 21521003);the National Key Research and Development Program of China(2017YFA0505200);the Beijing Outstanding Young Scientist Program(BJJWZYJH01201910001001).
Plant metabolites are dynamically modified and distributed in response to environmental changes.How-ever,it is poorly understood how metabolic change functions in plant stress responses.Maintaining ion ho-meostasis un...
关键词：Arabidopsis thaliana endogenous small molecules H^(+)-ATPase Na^(+)/H^(+)antiporter salt stress 
Neuroprotective effect of deferoxamine on erastin-induced ferroptosis in primary cortical neurons被引量：11
《Neural Regeneration Research》2020年第8期1539-1545,共7页Yan Zhang Bao-You Fan Yi-Lin Pang Wen-Yuan Shen Xu Wang Chen-Xi Zhao Wen-Xiang Li Chang Liu Xiao-Hong Kong Guang-Zhi Ning Shi-Qing Feng Xue Yao 
supported by the National Natural Science Foundation of China,Nos.81672171(to XY),81620108018(to SQF),81772342(to GZN);the State Key Laboratory of Medicinal Chemical Biology of Nankai University of China,No.2017027(to XY)
The iron chelator deferoxamine has been shown to inhibit ferroptosis in spinal cord injury.However,it is unclear whether deferoxamine directly protects neurons from ferroptotic cell death.By comparing the survival rat...
关键词：cystine/glutamate antiporter system light chain DEFEROXAMINE erastin ferroptosis glutathione peroxidase 4 neurons NEUROPROTECTION reactive oxygen species 
甘蓝型油菜钙离子转运蛋白CAX家族基因生物信息学及其对镉胁迫响应表达分析被引量：10
《植物生理学报》2019年第5期596-608,共13页廖琼 周婷 肖燕 唐天骄 宋海星 官春云 华营鹏 张振华 
国家重点研发计划(2017YFD0200103);国家自然科学基金(31801923、31101596和31372130);湖南农业大学‘双一流’建设(kxk201801005)~~
CAXs(Cation/H+ exchanger antiporter)是一类重要的阳离子跨膜转运蛋白,在调控植物Ca2+平衡,参与转运金属离子Cd2+和Mn2+中发挥了重要作用,但在甘蓝型油菜中尚缺乏系统研究。本文利用生物信息学的方法对甘蓝型油菜CAX家族成员的基因拷...
关键词：CAX(Cation/H+ EXCHANGER antiporter) 甘蓝型油菜 镉胁迫 生物信息学 
A Putative Chloroplast-Localized Ca2＋/H＋ Antiporter CCHA1 Is Involved in Calcium and pH Homeostasis and Required for PSII Function in Arabidopsis被引量：2
《Molecular Plant》2016年第8期1183-1196,共14页Chao Wang Weitao Xu Honglei Jin Taijie Zhang Jianbin Lai Xuan Zhou Shengchun Zhang Shengjie Liu Xuewu Duan Hongbin Wang Changlian Peng Chengwei Yang 
Calcium is important for chloroplast, not only in its photosynthetic but also nonphotosynthetic functions. Mul- tiple Ca2＋/H＋ transporters and channels have been described and studied in the plasma membrane and orga...
关键词：Ca2＋/H＋ antiporter Ca2＋ homeostasis pH homeostasis CCHA1 
Crystal structures of MdfA complexed with acetylcholine and inhibitor reserpine
《Biophysics Reports》2016年第2期78-85,共8页Ming Liu lie Heng Yuan Gao Xianping Wang 
The DHA12 family of transporters contains a number of prokaryotic and eukaryote membrane proteins. Some of these proteins share conserved sites intrinsic to substrate recognition, structural stabilization and conforma...
关键词：MdfA RESERPINE DHA12 ANTIPORTER ACETYLCHOLINE 
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