RASAGILINE

作品数：17被引量：31H指数：4
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Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals with Parkinson’s Disease: A Systematic Review and Meta-Analysis
《Advances in Parkinson's Disease》2024年第3期27-56,共30页Paula Abola Mitchell Wolden 
Objective: In the manuscript titled Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals with Parkinsons Disease: A Systematic Review and Meta-Analysis, the objective was to ...
关键词：Parkinson’s Disease Monoamine Oxidase-B Inhibitor RASAGILINE Non-Motor Symptoms Motor Symptoms UPDRS PDQ-39 OFF Time 
Type-B monoamine oxidase inhibitors in neurological diseases:clinical applications based on preclinical findings被引量：3
《Neural Regeneration Research》2024年第1期16-21,共6页Marika Alborghetti Edoardo Bianchini Lanfranco De Carolis Silvia Galli Francesco E.Pontieri Domiziana Rinaldi 
Type-B monoamine oxidase inhibitors,encompassing selegiline,rasagiline,and safinamide,are available to treat Parkinson's disease.These drugs ameliorate motor symptoms and improve motor fluctuation in the advanced stag...
关键词：glial cell line-derived neurotrophic factor(GDNF) GLUTAMATE neurological disorders NEUROPROTECTION Parkinson's disease preclinical studies RASAGILINE SAFINAMIDE SELEGILINE type-B monoamine oxidase(MAO_(B))inhibitors 
Clinical Experience with Generic Rasagiline (Ralago<sup>®</sup>) in Patients with Parkinson’s Disease: An Open-Label, Multicenter, Observational Study
《Advances in Parkinson's Disease》2019年第2期18-34,共17页Dávid Pintér Júlia Lajtos József Janszky Norbert Kovács 
Background: Antiparkinsonian pharmacotherapy represents one of the most important expenses related to Parkinson’s disease. The application of generic drugs may help to reduce the economic burden of the disease;howeve...
关键词：Parkinson’s Disease RASAGILINE Generic Antiparkinsonian Drugs HEALTH-RELATED Quality of Life 
Efficacy and safety of rasagiline in Chinese patients with early Parkinson’s disease:a randomized, double-blind,parallel,placebo-controlled,fixed-dose study被引量：6
《Translational Neurodegeneration》2018年第1期352-360,共9页Zhenxin Zhang Jian Wang Shengdi Chen Chunfeng Liu Baorong Zhang Rong Peng Shenggang Sun Xiangru Sun Gang Zhao Qiumin Qu Yansheng Li Suiqiang Zhu Xiaoping Pan Ming Shao Yanping Wang 
Background:Rasagiline is a monoamine oxidase-B inhibitor used for Parkinson’s disease(PD)treatment,but its effectiveness on Chinese patients is unclear.This study aimed to evaluate the efficacy and safety of rasagili...
关键词：Parkinson’s disease MONOAMINE OXIDASE inhibitor RASAGILINE MONOTHERAPY China 
Adjunct rasagiline to treat Parkinson’s disease with motor fluctuations:a randomized,double-blind study in China
《Translational Neurodegeneration》2018年第1期127-137,共11页Zhenxin Zhang Ming Shao Shengdi Chen Chunfeng Liu Rong Peng Yansheng Li Jian Wang Suiqiang Zhu Qiumin Qu Xiaoying Zhang Haibo Chen Xiangru Sun Yanping Wang Shenggang Sun Baorong Zhang Jimei Li Xiaoping Pan Gang Zhao 
Background:The use of adjunct rasagiline in levodopa-treated patients with Parkinson’s disease and motor fluctuations is supported by findings from large-scale clinical studies.This study is to investigate the effica...
关键词：Parkinson’s disease RASAGILINE ADJUNCT Motor fluctuations OFF time Quality of life China 
No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice
《Neural Regeneration Research》2016年第8期1339-1346,共8页Cheng-you Zheng Bao-jian Guo Wei Cai Wei Cui Shing-hung Mak Yu-qiang Wang Simon Ming-yuen Lee Yi-fan Han Zai-jun Zhang 
supported by grants from the Natural Science Foundation of Guangdong Province of China,No.2015A030313317;a grant from the Science and Technology Program of Guangzhou City of China,No.2014J4100097;partially by a grant from the Science and Technology Development Fund(FDCT) of Macao Special Administrative Region,No.134/2014/A3;a grant from the Research Committee of University of Macao,No.MYRG139(Y1-L4)-ICMS12-LMY and MYRG2015-00214-ICMS-QRCM;grants from the Research Grants Council of Hong Kong Special Administrative Region of China,No.561011,15101014;the Hong Kong Polytechnic University of China,No.G-SB10,G-UC15 and G-YBGQ
Rasagiline,a monoamine oxidase-B inhibitor,and bis（propyl）-cognitin（B3C）,a novel dimer are reported to be neuroprotective.Herein,the synergistical neuroprotection produced by rasagiline and B3 C was investigated i...
关键词：nerve regeneration Parkinson＇s disease bis（propyl）-cognitin RASAGILINE monoamine oxidase B DOPAMINE multitarget synergism NEUROPROTECTION neural regeneration 
Quantitative EEG Changes in Patients with Parkinson’s Disease during Therapy with Rasagiline
《Advances in Parkinson's Disease》2014年第3期22-34,共13页Wilfried Dimpfel Christian Oehlwein Josef Anton Hoffmann Thomas Müller 
It has been suggested that in patients with Parkinson’s disease (PD) metabolism of the MAO-B inhibitor selegiline to methamphetamine may contribute and/or exacerbate sleep problems, possibly leading to deficits of co...
关键词：RASAGILINE SELEGILINE Quantitative EEG CATEEM^(■) Parkinson’s Disease COGNITION 
Monoamine oxidase-B (MAO-B) inhibitors: implications for disease-modification in Parkinson’s disease被引量：6
《Translational Neurodegeneration》2013年第1期124-133,共10页Kay Cheong Teo Shu-Leong Ho 
The authors’work is supported by the Henry G Leong Endowed Professorship;the Donation Fund for Neurology Research,University of Hong Kong.
There is a substantial amount of evidence from experimental parkinsonian models to show the neuroprotective effects of monoamine oxidase-B(MAOB)inhibitors.They have been studied for their potential disease-modifying e...
关键词：Parkinson's disease Monoamine oxidase-B inhibitors Disease-modification Neuroprotection SELEGILINE RASAGILINE 
Bio-analytical method development and validation of Rasagiline by high performance liquid chromatography tandem mass spectrometry detection and its application to pharmacokinetic study被引量：2
《Journal of Pharmaceutical Analysis》2012年第5期342-349,共8页Ravi Kumar Konda Babu Rao Chandu B.R.Challa Chandrasekhar B.Kothapalli 
The most suitable bio-analytical method based on liquid liquid extraction has been developed and validated for quantification of Rasagiline in human plasma. Rasagiline-13C3 mesylate was used as an internal standard fo...
关键词：High performance liquid chromatography Mass spectrometry RASAGILINE Liquid-liquid extraction 
(R)-N-丙炔基-1-氨基茚满的合成被引量：3
《科技资讯》2008年第30期6-7,共2页梁丽莉 施小新 孙郁 
上海市教育发展基金(03SG27);国家自然科学基金(A-20172015)
本文以1-茚酮为原料,先合成消旋体,然后经L-酒石酸拆分的方法合成(R)-N-丙炔基-1-氨基茚满(1,Rasagiline)。成本低廉,易于操作,适合工业化生产,总收率10%。
关键词：(R)-N-丙炔基-1-氨基茚满 RASAGILINE 合成 
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