PARKINSON_DISEASE

作品数：125被引量：198H指数：7
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相关作者：余舒扬陈滢陈晓春王涛张巧俊更多>>
相关机构：首都医科大学附属北京天坛医院福建医科大学环境与疾病相关基因教育部重点实验室西安交通大学更多>>
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Relationship among Parkinson’s disease, constipation, microbes, and microbiological therapy被引量：1
《World Journal of Gastroenterology》2024年第3期225-237,共13页Xin-Yang Yuan Yu-Sen Chen Zhou Liu 
This comprehensive review elucidates the complex interplay between gut microbiota and constipation in Parkinson’s disease(PD),a prevalent non-motor symptom contributing significantly to patients’morbidity.A marked a...
关键词：Parkinson disease CONSTIPATION Gut microbiota PREBIOTICS PROBIOTICS Fecal microbiota transplantation 
Gene therapy for Parkinson’s Disease and Ethical Challenges: A Systematic Review
《Advances in Parkinson's Disease》2023年第2期9-28,共20页Théodora M. Zohoncon Joseph Sawadogo Abdou Azaque Zoure Abdoul Karim Ouattara Marie N. L. Ouedraogo Luc Zongo Paul Ouedraogo Florencia W. Djigma Christelle W. M. Nadembèga Raphael Kabore Djénéba Ouermi Dorcas Obiri-Yeboah Jacques Simpore 
Background: Parkinson’s disease (PD) is a complex, multifactorial neurodegenerative disorder with a pathophysiology deriving from the synergy of abnormal aggregation of neuroinflammation, synuclein and dysfunction of...
关键词：Neurodegenerative Diseases Parkinson Disease Molecular Mechanism Gene Therapy Gene Therapy Ethics 
Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease被引量：2
《Translational Neurodegeneration》2022年第1期390-400,共11页Matilde Bongianni Mauro Catalan Daniela Perra Elena Fontana Francesco Janes Claudio Bertolotti Luca Sacchetto Stefano Capaldi Matteo Tagliapietra Paola Polverino Valentina Tommasini Giulia Bellavita Elham Ataie Kachoie Roberto Baruca Andrea Bernardini Mariarosaria Valente Michele Fiorini Erika Bronzato Stefano Tamburin Laura Bertolasi Lorenzo Brozzetti Maria Paola Cecchini Gianluigi Gigli Salvatore Monaco Paolo Manganotti Gianluigi Zanusso 
Fondazione Cariverona:“Development and validation of a novel molecular assay forα-synuclein in patients with Parkinson’s disease and otherα-synucleinopathies”#2018.0708 to GZ and Brain Research Verona Foundation to GZ.Dr.Elena Fontana is attending a doctoral fellowship supported by COPAN group.
Background: In patients with Parkinson’s disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate as in other α-synucle...
关键词：Parkinson disease ALPHA-SYNUCLEIN Real-time quaking-induced conversion assay Olfactory mucosa Cerebrospinal fluid 
Effect of Varenicline on Detrusor Overactivity in Rat Model of Parkinson’s Disease Induced by Intranigral 6-Hydroxydopamine
《Advances in Parkinson's Disease》2022年第1期1-10,共10页Zeynep Mine Altunay Fatma Rüyal Tan Nermin Bölükbaşı Funda Fatma Bölükbaşı Hatip Izzettin Hatip-Al-Khatib 
Background: Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Bladder dysfunction is the common non-motor symptom of PD, most often presenting with ...
关键词：Nicotinic Cholinergic Receptors Overactive Bladder VARENICLINE Parkinson Disease Alpha7 Nicotinic Cholinergic Receptor Agonists 
The prevalence of freezing of gait in Parkinson’s disease and in patients with different disease durations and severities被引量：9
《Chinese Neurosurgical Journal》2020年第2期92-102,共11页Hong-Liang Ge Xiao-Yong Chen Yuan-Xiang Lin Ting-Juan Ge Liang-Hong Yu Zhang-Ya Lin Xi-Yue Wu De-Zhi Kang Chen-Yu Ding 
Background:The prevalence rates of freezing of gait(FOG)in Parkinson’s disease(PD)vary widely,ranging from 14.0 to 55.1%.Our aim is to calculate the overall prevalence of FOG in all PD patients with different disease...
关键词：PREVALENCE FREEZING GAIT Parkinson disease 
Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson’s disease被引量：5
《Journal of Traditional Chinese Medicine》2019年第6期800-808,共9页Liu Quanfeng Sang Heon Kim Yung-Wei Sung Sok Cheon Pak Wonwoong Lee Jongki Hong Jaehwan Jang Kyoung Sang Cho Songhee Jeon Byung-Soo Koo 
Supported by the Dongguk University Research Fund of 2014
OBJECTIVE:To examine the role of KSOP1009(a modified formulation of Suhexiang Wan essential oil)in an animal model of Parkinson's disease(PD)induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine(MPTP)injection.METH...
关键词：Parkinson disease 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine Mitochondria Reactive oxygen species Suhexiang Wan 
Racial Disparities in Parkinson Disease: A Systematic Review of the Literature
《Advances in Parkinson's Disease》2016年第4期87-96,共10页Chantale O. Branson Andrew Ferree Anna D. Hohler Marie-Helene Saint-Hilaire 
Racial differences in the prevalence of Parkinson’s disease (PD) have been reported for decades. Many of the earliest reports were flawed because they were based on crude datasets, such as hospital databases, death c...
关键词：Racial and Ethnic Disparities EPIDEMIOLOGY Parkinson’s Disease 
The biomarkers of immune dysregulation and inflammation response in Parkinson disease被引量：3
《Translational Neurodegeneration》2016年第1期131-136,共6页Li Chen Mingshu Mo Guangning Li Luan Cen Lei Wei Yousheng Xiao Xiang Chen Shaomin Li Xinling Yang Shaogang Qu Pingyi Xu 
This review was supported by research grants from the State Key Development Program for Basic Research of China(2011CB510000);the National Natural Science Foundation of China(81271428,81471292,U1503222 and 81430021);the keypoint Science Foundation of Guangdong of China(2015A030311021);a grant supported by technology project of Guangzhou(201604020152);a grant supported by assisting research project of science and technology for Xinjiang(201591160).
Parkinson’s disease(PD)is referring to the multi-systemicα-synucleinopathy with Lewy bodies deposited in midbrain.In ageing,the environmental and genetic factors work together and overactive major histocompatibility...
关键词：Parkinson’s disease α-synucleinopathy INFLAMMATION Biomarkers 
Probabilistic tractography of the posterior subthalamic area in Parkinson’s disease patients
《Journal of Biomedical Science and Engineering》2013年第3期381-390,共10页M.G.GarcIa-Gomar Luis Concha S.Alcauter J.Soto Abraham J.D.Carrillo-Ruiz G.Castro Farfan Francisco Velasco Campos 
supported by the National Council of Science and Technology in Mexico(CONACyT)from grant 0114218-2009;a CONACyT scholarship to GGMG(CVU 468870).
Deep brain stimulation (DBS) is a non-pharmacological treatment for Parkinson’s disease (PD), and its efficacy depends largely on which anatomical structure (target) is stimulated. The subthalamic nucleus (STN) is on...
关键词：Parkinson Disease(PD) Posterior Subthalamic Area(PSA) TRACTOGRAPHY Track-Density Images(TDI) 
Parkinson disease drug screening based on the interaction between D2 dopamine receptor and beta-arrestin 2 detected by capillary zone electrophoresis被引量：1
《Protein & Cell》2011年第11期899-905,共7页Zheng Zhou Jun-Ming Liao Peng Zhang Jun-Bao Fan Jie Chen Yi Liang 
by the National Key Basic Research Foundation of China(Grant No.2006CB910301);the National Programs for High Technology Research and Development Program(863 Program)(No.2004AA404260);the National Natural Science Foundation of China(Grant Nos.30970599 and 30770421);the Fundamental Research Funds for the Central Universities of China(Grant No.1104006).
Parkinson’s disease is the second most common neurodegenerative disease in the world.Beta-arrestin-2 has been reported to be an important protein involved in D2 dopamine receptor desensitization,which is essential to...
关键词：drug screening D2 dopamine receptor beta-arrestin-2 capillary zone electrophoresis proteinprotein interaction Parkinson’s disease 
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