PHAGE

作品数:160被引量:171H指数:6
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相关领域:医药卫生更多>>
相关作者:李莉梁玉婷崔泽林洪伟刘思远更多>>
相关机构:上海市第一人民医院中国科学院昆明理工大学河北师范大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家重点实验室开放基金福建省科技计划项目更多>>
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结核分枝杆菌Phage蛋白的抗原表位预测及生物信息学分析
《医学理论与实践》2025年第1期14-19,共6页黄和明 张娟 李高驰 周海金 
广东省深圳市科技创新计划基础研究(No.JCYJ20180305125647151)。
目的:应用生物信息学软件对结核分枝杆菌Rv1579c基因编码的Phage蛋白结构和功能进行预测分析。方法:从NCBI Gene数据库中获取Rv1579c编码的氨基酸序列;通过ProtParam、ProtScale、NetPhos、TMHMM、SOPMA、SWISS-MODEL在线网站分别对Phag...
关键词:结核分枝杆菌 焦亡 PHAGE 生物信息学 
The phage anti-restriction induced system:new insights into bacterial immunity and bacteriophage escape strategies
《Signal Transduction and Targeted Therapy》2024年第11期4753-4754,共2页Yi Zhong Volker M.Lauschke 
funded by the Swedish Research Council[2021-02801 and 2023-03015];the Robert Bosch Foundation.
Two recent publications in Nature reveal the detailed structural mechanisms underlying the recognition of infection by the bacterial Phage Anti-Restriction Induced System(PARIS).1,2 These findings are important as the...
关键词:IMMUNITY SYSTEM finding 
Antibacterial activity evaluation of a novel K3-specific phage against Acinetobacter baumannii and evidence for receptor-binding domain transfer across morphologies
《Virologica Sinica》2024年第5期767-781,共15页Xiangkuan Zheng Meihan Liu Pei Li Sixiang Xu Long Chen Guoxin Xu Xiaoxiao Pang Hong Du Yishan zheng Xiang Huo Zhongming Tan Juan Li Zhirong Li Wei Zhang 
supported by a grant from the NHC Key laboratory of Enteric Pathogenic Microbiology(Jiangsu Provincial Center for Disease Control and Prevention,EM202303);Guizhou Province Science and Technology Plan Project(Grant No.QKH[2023]008);the Science Foundation of Jiangsu Province Health Department(ZDB2020014);National Natural Science Foundation of China(82002108);Science and Technology Program of Suzhou(SKYD2023050);Suzhou Municipal Health Commission(KJXW2023061).
Acinetobacter baumannii(A.baumannii)poses a serious public health challenge due to its notorious antimicrobial resistance,particularly carbapenem-resistant A.baumannii(CRAB).In this study,we isolated a virulent phage,...
关键词:PHAGE A.baumannii CARBAPENEM-RESISTANT Capsule type Tail fiber protein Antibacterial activity 
Another piece of puzzle for the human microbiome: the gut virome under dietary modulation
《Journal of Genetics and Genomics》2024年第10期983-996,共14页Fengxiang Zhao Jinfeng Wang 
This work was supported by the National Key Research and Development Program of China(2022YFA1304102);the National Natural Science Foundation of China(32070122,32370053,T2341010);the Chinese Universities Scientific Fund(2023RC022);Pinduoduo-Chinaa Agricultural University Research Fund(PC2023B02015);the 2115 Talent Development Program of China Agricultural University.
The virome is the most abundant and highly variable microbial consortium in the gut.Because of difficulties in isolating and culturing gut viruses and the lack of reference genomes,the virome has remained a rela-tivel...
关键词:Diet Gut virome Phage lifestyle Auxiliary metabolic genes Horizontal gene transfer 
Mobile CRISPR-Cas9 based anti-phage system in E. coli
《Frontiers of Chemical Science and Engineering》2022年第8期1281-1289,共9页Zhou Cao Yuxin Ma Bin Jia Ying-Jin Yuan 
support from the National Key Research and Development Program of China(Grant No.2019YFA0903800);the National Natural Science Foundation of China(Grant Nos.31800719,21621004);the International(regional)cooperation and exchange projects(Grant No.31861143017).
Escherichia coli is one of the most important microbial cell factories,but infection by bacteriophages in the environment may have a huge impact on its application in industrial production.Here,we developed a mobile C...
关键词:phage infections anti-phage CRISPR-Cas9 conjugative transfer synthetic biology 
Preparation of Monoclonal Antibody Against Clostridium perfringensα-toxin and Screening and Identification of Phage Display Technology
《Journal of Northeast Agricultural University(English Edition)》2020年第3期76-86,共11页Wang Hong-wei Liu Hai-xin Xie Zhen-zhen Zhang Yue Zhong Ming Li Guang-xing 
Supported by the National Natural Science Foundation of China(31370140,31372438)。
Clostridium perfringens phospholipase C(plc),also calledα-toxin,is encoded by the plc gene Clostridium perfringers.The production ofα-toxin can lead to the occurrence of gas gangrene.Vaccination is considered as one...
关键词:Clostridium perfringens phospholipase C PHAGE PEPTIDE 
Biological Effects of Chlamydiaphage phi CPG1 Capsid Protein Vp1 on Chlamydia Trachomatis In Vitro and In Vivo
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2017年第1期115-121,共7页王生 郭睿 郭媛丽 邵丽丽 刘洋 魏世娟 刘原君 刘全忠 
supported by National Natural Science Foundation of China(No.31370211)
The researches on chlamydia in recent years show that chlamydia bacteriophage may be a potential and effective means to solve the clinical infection of chlamydia trachomatis(Ct). We investigated the biological effec...
关键词:chlamydia trachomatis trachoma mice phage Vp1 protein 
Research Progress of Using Phage Display Technology to Screen Virus Affinity Peptides
《Animal Husbandry and Feed Science》2016年第4期194-198,共5页Zhang Nana Zheng Guanmin Wang Fangyu Ren Tingting Hao Huifang Zhang Yifang Zhang Gaiping Lu Qingxia 
Supported by Scientific and Technological Project of Henan Province(162102110136);Science and Technology Foundation for Outstanding Young Scientists of Henan Academy of Agricultural Sciences(2016YQ28)
Development and application of phage display technology and research progress of virus affinity peptide were summarized in the paper,and a preliminary outlook for future development was put forward. The paper laid a f...
关键词:phage affinity Phage Screen screening library preliminary vaccine epitope purification 
Multiple-site mutations of phage Bp7 endolysin improves its activities against target bacteria
《Virologica Sinica》2015年第5期386-395,共10页Can Zhang Yuanchao Wang Huzhi Sun Huiying Ren 
provided by the Natural Science Foundation of Shandong Province,China (ZR2015CM020 and ZR2013 CQ024)
The widespread use of antibiotics has caused serious drug resistance. Bacteria that were once easily treatable are now extremely difficult to treat. Endolysin can be used as an alternative to antibiotics for the treat...
关键词:BACTERIOPHAGE Bp7 endolysin(Bp7e) Bp7 ENDOLYSIN MU 
Variation of resistance and infectivity between Pseudomonas fluorescens SBW25 and bacteriophage Ф2 and its therapeutic implications
《Virologica Sinica》2015年第1期59-62,共4页Hanchen Chen Guohua Chen 
supported by the Open Funding Project of the Engineering Research Center of Eco-environment in Three Gorges Reservoir Region-Ministry of Education (KF2013-07)
Dear Editor,Studies of the coevolutionary dynamics between Pseudomonas fluorescens SBW25 and bacteriophageФ2 can explore host resistance and parasite infectivity with applications in the ecological and therapeutic fi...
关键词:PHAGE PARASITE declined poral PHAGE INFECTIVE VIEWPOINT spatially directional FIGURE 
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