PHAGE

作品数：160被引量：171H指数：6
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相关机构：上海市第一人民医院中国科学院昆明理工大学河北师范大学更多>>
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Characterization and genomics analysis of phage PGX1 against multidrug-resistant enterotoxigenic E.coli with in vivo and in vitro efficacy assessment
《Animal Diseases》2025年第1期85-100,共16页Dayue Hu Ping Qian Dongyang Gao Xinxin Li Linkang Wang Hongyue Ji Shuang Wang Xiangmin Li 
supported by grants from the National Program on Key Research Project of China[2022YFD1800800,2021YFD1800300];the Yingzi Tech&Huazhong Agricultural University Intelligent Research Institute of Food Health[No.IRIFH202209,No.IRIFH202301];The National Program on Key Research Project of China,2022YFD1800800,Ping Qian,2021YFD1800300,Ping Qian,The Yingzi Tech&Huazhong Agricultural University Intelligent Research Institute of Food Health,IRIFH202209,Ping Qian,IRIFH202301,Ping Qian.
Enterotoxigenic E.coli is one of the bacterial pathogens contributing to the global resistance crisis in public health and animal husbandry.The problem of antibiotic resistance is becoming more and more serious,and ph...
关键词：Enterotoxigenic E.coli Multidrug-resistant bacteria Phage PGX1 
Characterization and genomic analysis of Pseudoalteromonas phage v B_Pal P_Y7,representing a novel viral genus,Miuvirus
《Journal of Oceanology and Limnology》2025年第1期299-312,共14页Miaolan WU Hongmin WANG Ye MI Yantao LIANG Kaiyang ZHENG Yundan LIU Yue DONG Linyi REN Yue SU Hongbing SHAO Yeong Yik SUNG Wen Jye MOK Li Lian WONG Min WANG 
the National Natural Science Foundation of China(Nos.42188102,42120104006,41976117,42176111);the Fundamental Research Funds for the Central Universities(Nos.202172002,201812002);the funding from Andrew Mc Minn。
Pseudoalteromonas is a group of marine bacteria widespread in diverse marine sediments,producing a wide range of bioactive compounds.However,only a limited number of Pseudoalteromonas phages have been isolated and stu...
关键词：Pseudoalteromonas phage genomic analysis phylogenetic analysis viral cluster 
结核分枝杆菌Phage蛋白的抗原表位预测及生物信息学分析
《医学理论与实践》2025年第1期14-19,共6页黄和明 张娟 李高驰 周海金 
广东省深圳市科技创新计划基础研究(No.JCYJ20180305125647151)。
目的:应用生物信息学软件对结核分枝杆菌Rv1579c基因编码的Phage蛋白结构和功能进行预测分析。方法:从NCBI Gene数据库中获取Rv1579c编码的氨基酸序列;通过ProtParam、ProtScale、NetPhos、TMHMM、SOPMA、SWISS-MODEL在线网站分别对Phag...
关键词：结核分枝杆菌 焦亡 PHAGE 生物信息学 
Harnessing a T1 Phage-Derived Spanin for Developing Phage-Based Antimicrobial Development被引量：1
《BioDesign Research》2024年第1期28-38,共11页Wakana Yamashita Shinjiro Ojima Azumi Tamura Aa Haeruman Azam Kohei Kondo Zhang Yuancheng Longzhu Cui Masaki Shintani Masato Suzuki Yoshimasa Takahashi Koichi Watashi Satoshi Tsuneda Kotaro Kiga 
supported by the Japan Agency for Medical Research and Development under grant numbers JP23wm0325065,JP22fk0108532,JP21fk0108496,and JP21 wm0325022 to K.K.;grant number JP21gm1610002 to L.C.and K.K.;JSPS KAKENHI grants numbers 21H02110 and 21K19666 to K.K.
The global increase in the prevalence of drug-resistant bacteria has necessitated the development of alternative treatments that do not rely on conventional antimicrobial agents.Using bacteriophage-derived lytic enzym...
关键词：DEVELOPMENT ANTIMICROBIAL DEVELOPING harnessing phage-based phage-derived spanin 
The phage anti-restriction induced system:new insights into bacterial immunity and bacteriophage escape strategies
《Signal Transduction and Targeted Therapy》2024年第11期4753-4754,共2页Yi Zhong Volker M.Lauschke 
funded by the Swedish Research Council[2021-02801 and 2023-03015];the Robert Bosch Foundation.
Two recent publications in Nature reveal the detailed structural mechanisms underlying the recognition of infection by the bacterial Phage Anti-Restriction Induced System(PARIS).1,2 These findings are important as the...
关键词：IMMUNITY SYSTEM finding 
Antibacterial activity evaluation of a novel K3-specific phage against Acinetobacter baumannii and evidence for receptor-binding domain transfer across morphologies
《Virologica Sinica》2024年第5期767-781,共15页Xiangkuan Zheng Meihan Liu Pei Li Sixiang Xu Long Chen Guoxin Xu Xiaoxiao Pang Hong Du Yishan zheng Xiang Huo Zhongming Tan Juan Li Zhirong Li Wei Zhang 
supported by a grant from the NHC Key laboratory of Enteric Pathogenic Microbiology(Jiangsu Provincial Center for Disease Control and Prevention,EM202303);Guizhou Province Science and Technology Plan Project(Grant No.QKH[2023]008);the Science Foundation of Jiangsu Province Health Department(ZDB2020014);National Natural Science Foundation of China(82002108);Science and Technology Program of Suzhou(SKYD2023050);Suzhou Municipal Health Commission(KJXW2023061).
Acinetobacter baumannii(A.baumannii)poses a serious public health challenge due to its notorious antimicrobial resistance,particularly carbapenem-resistant A.baumannii(CRAB).In this study,we isolated a virulent phage,...
关键词：PHAGE A.baumannii CARBAPENEM-RESISTANT Capsule type Tail fiber protein Antibacterial activity 
Another piece of puzzle for the human microbiome: the gut virome under dietary modulation
《Journal of Genetics and Genomics》2024年第10期983-996,共14页Fengxiang Zhao Jinfeng Wang 
This work was supported by the National Key Research and Development Program of China(2022YFA1304102);the National Natural Science Foundation of China(32070122,32370053,T2341010);the Chinese Universities Scientific Fund(2023RC022);Pinduoduo-Chinaa Agricultural University Research Fund(PC2023B02015);the 2115 Talent Development Program of China Agricultural University.
The virome is the most abundant and highly variable microbial consortium in the gut.Because of difficulties in isolating and culturing gut viruses and the lack of reference genomes,the virome has remained a rela-tivel...
关键词：Diet Gut virome Phage lifestyle Auxiliary metabolic genes Horizontal gene transfer 
Catalytically active prokaryotic Argonautes employ phospholipase D family proteins to strengthen immunity against different genetic invaders
《mLife》2024年第3期403-416,共14页Feiyue Cheng Aici Wu Zhihua Li Jing Xu Xifeng Cao Haiying Yu Zhenquan Liu Rui Wang Wenyuan Han Hua Xiang Ming Li 
This work was supported by the Science&Technology Fundamental Resources Investigation Program(2022FY101100);the Strategic Priority Research Program of the Chinese Academy of Sciences(Precision seed design and breeding)(XDA24020101);the National Natural Science Foundation of China(Nos.31970544,31970545,32022003,32150020,32200057,and 32270092);the Youth Innovation Promotion Association of CAS(No.2020090);the China National Postdoctoral Program for Innovative Talents(BX20220331);the China Postdoctoral Science Foundation(2022M720160);the Special Research Assistant Program of Chinese Academy of Sciences(No.2023000056).
Prokaryotic Argonautes(pAgos)provide bacteria and archaea with immunity against plasmids and viruses.Catalytically active pAgos utilize short oligonucleotides as guides to directly cleave foreign nucleic acids,while i...
关键词：ARGONAUTE DNA interference genome editing phage defense PLD protein 
Dual role of phage terminase in Salmonella enterica oxidative stress response
《Engineering Microbiology》2024年第3期67-69,共3页Senfeng Zhang Shengsheng Ma Feizuo Wang Chunyi Hu 
The adaptive survival mechanisms of bacterial pathogens under host-induced stress are crucial for understanding pathogenesis.Recently,Uppalapati et al.revealed a unique dual function of the Gifsy-1 prophage terminase ...
关键词：PHAGE TERMINASE Oxidative stress TRNA SOS response 
Molecular and structural basis of an ATPase-nuclease dualenzyme anti-phage defense complex
《Cell Research》2024年第8期545-555,共11页Qiyin An Yong Wang Zhenhua Tian Jie Han Jinyue Li Fumeng Liao Feiyang Yu Haiyan Zhao Yancheng Wen Heng Zhang Zengqin Deng 
supported by the National Key R&D Program of China(2022YFA1303500);the CAS Pioneer Hundred Talents Program to Z.D.
Coupling distinct enzymatic effectors emerges as an efficient strategy for defense against phage infection in bacterial immune responses,such as the widely studied nuclease and cyclase activities in the type III CRISP...
关键词：ENZYMATIC PLANAR neighboring 
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