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作品数:1229被引量:1986H指数:18
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相关领域:医药卫生更多>>
相关作者:魏海明孙汭田志刚邹世恩卢芳汀更多>>
相关机构:中国科学技术大学四川大学同济大学附属同济医院浙江省人民医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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  • 期刊=Bioactive Materialsx
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A two-pronged approach to inhibit ferroptosis of MSCs caused by the iron overload in postmenopausal osteoporosis and promote osseointegration of titanium implant被引量:2
《Bioactive Materials》2024年第11期336-354,共19页Yulu Yang Xianhui Zhang Yao Yang Pengfei Gao Wuzhe Fan Tao Zheng Weihu Yang Yu Tang Kaiyong Cai 
State Key Project of Research and Development(2022YFB3804400);National Natural Science Foundation of China(32071334,52333011&51825302);Natural Science Foundation of Chongqing(cstc2021jcyj-cxttX0002 and CSTB2023NSCQ-MSX0074);Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology(Chongqing University);Ministry of Education(CQKLBST-2023-001).
Postmenopausal osteoporosis(PMOP)is a prevalent condition among elderly women.After menopause,women exhibit decreased iron excretion,which is prone to osteoporosis.To design a specific titanium implant for PMOP,we fir...
关键词:Postmenopausal osteoporosis Iron overload Ferroptosis Caffeic acid nanosphere Ti implant 
Barnacle inspired strategy combined with solvent exchange for enhancing wet adhesion of hydrogels to promote seawater-immersed wound healing
《Bioactive Materials》2024年第11期46-60,共15页Guiyuan Zhao Aijia Zhang Xiangyan Chen Guangli Xiang Tianze Jiang Xia Zhao 
National Natural Science Foundation of China(U21A20297);Natural Science Foundation of Qingdao(202406).
Hydrogels are promising materials for wound protection,but in wet,or underwater environments,the hydration layer and swelling of hydrogels can seriously reduce adhesion and limit their application.In this study,inspir...
关键词:BARNACLE Solvent exchange HYDROGEL Wet adhesion Wound healing 
Extracellular vesicles released by transforming growth factor-beta 1-preconditional mesenchymal stem cells promote recovery in mice with spinal cord injury被引量:1
《Bioactive Materials》2024年第5期135-149,共15页Guoliang Chen Kuileung Tong Shiming Li Zerong Huang Shuangjiang Liu Haoran Zhu Yanheng Zhong Zhisen Zhou Genlong Jiao Fuxin Wei Ningning Chen 
supported by the Fundamental Research Funds for the Central Universities(No.21623310);the Dongguan Science and Technology of Social Development Program(No.20231800939902);the National Natural Science Foundation of China(No.81801907);the Guangdong Basic and Applied Basic Research Foundation(No.2022A1515140171);the Medical Joint Fund of Jinan University(No.YXJC2022011);Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research(No.ZDSYS20230626091402006).
Spinal cord injury(SCI)causes neuroinflammation,neuronal death,and severe axonal connections.Alleviating neuroinflammation,protecting residual cells and promoting neuronal regeneration via endogenous neural stem cells...
关键词:Endogenous neural stem cells Extracellular vesicles Mesenchymal stem cells mTORC2/rictor pathway Spinal cord injury TGF-β1 
Micro-nanofiber composite biomimetic conduits promote long-gap peripheral nerve regeneration in canine models被引量:2
《Bioactive Materials》2023年第12期98-115,共18页Xianhao Dong Yueyue Yang Zheheng Bao Adam C.Midgley Feiyi Li Shuxin Dai Zhuangzhuang Yang Jin Wang Lihua Liu Wenlei Li Yayuan Zheng Siyang Liu Yang Liu Weijian Yu Jun Liu Meng Fan Meifeng Zhu Zhongyang Shen Gu Xiaosong Deling Kong 
National Natural Science Foundation of China projects(81921004,D.K.);National Natural Science Foundation of China projects(32201122,X.D.);National Natural Science Foundation of China projects(82272156,M.Z.);China Postdoctoral Science Foundation(2022M711705 X.D.);Key Military Medical Project(No.BLB21J008,D.K.);Tianjin Natural Science Foundation(C100303 F M.).
Peripheral nerve injuries may result in severe long-gap interruptions that are challenging to repair.Autografting is the gold standard surgical approach for repairing long-gap nerve injuries but can result in prominen...
关键词:composite fiber INJURIES 
Microvascular endothelial cells derived from spinal cord promote spinal cord injury repair被引量:7
《Bioactive Materials》2023年第11期36-49,共14页Zhifeng You Xu Gao Xinyi Kang Wen Yang Tiandi Xiong Yue Li Feng Wei Yan Zhuang Ting Zhang Yifu Sun He Shen Jianwu Dai 
the National Natural Science Foundation of China(Nos.81891002,81971178,32200806);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA16040701);the Youth Innovation Promotion Association CAS(No.2021319);the Natural Science Foundation of Jiangsu Province(No.BK20210127);the High-level Innovation and Entrepreneurship Talent Introduction Plan of Jiangsu Province.We acknowledge the CapitalBio Technology Inc.(Beijing,China)for RNA sequencing and proteomic sequencing.Schematic in Fig.2A and 6C were created with BioRender.com and were granted publication permission.We acknowledge a kind gift of PEGDA from Prof.Y.Du(Tsinghua University,Beijing,China)and help from PhD candiate WJ.Li in his lab on schematic preparation.
Neural regeneration after spinal cord injury (SCI) closely relates to the microvascular endothelial cell (MEC)- mediated neurovascular unit formation. However, the effects of central nerve system-derived MECs on neova...
关键词:Microvascular endothelial cells Spinal cord injury NeuroRegen scaffold Neural regeneration 
Microcarriers promote the through interface movement of mouse trophoblast stem cells by regulating stiffness被引量:2
《Bioactive Materials》2023年第10期196-205,共10页Zili Gao Jia Guo Bo Gou Zhen Gu Tan Jia Sinan Ma Liyuan Jiang Wenli Liu Lixun Zhou Qi Gu 
supported by National Natural Science Foundation of China(T2222029 and U21A20396);Strategic Priority Research Program of Chinese Academy of Sciences(XDA16020802);CAS Project for Young Scientists in Basic Research(YSBR-012);CAS Engineering Laboratory for Intelligent Organ Manufacturing(KFJ-PTXM-039).
Mechanical force is crucial in the whole process of embryonic development.However,the role of trophoblast mechanics during embryo implantation has rarely been studied.In this study,we constructed a model to explore th...
关键词:BIOMECHANICS MICROCARRIERS Embryo implantation Cell migration 
Exosomes from young healthy human plasma promote functional recovery from intracerebral hemorrhage via counteracting ferroptotic injury
《Bioactive Materials》2023年第9期1-14,共14页Wenqin Yang Ning Ding Ran Luo Qian Zhang Zhenhua Li Fengchun Zhao Shuixian Zhang Xuyang Zhang Tengyuan Zhou Haomiao Wang Long Wang Shengli Hu Guixue Wang Hua Feng Rong Hu 
supported by grants from National Natural Science Foundation of China(81671228);Program for Innovation research group of universities in Chongqing(CXQT19012);Chongqing municipal Science Fund for Distinguished Young Scholars(cstc2019jcyjjqX0030);Science and Technology Innovation Project of Jinfeng Laboratory,Chongqing,China(jfkyjf202203001).
Intracerebral hemorrhage (ICH), as a type of life-threatening and highly disabled disease, has limited therapeutic approaches. Here, we show that exosomes derived from young healthy human plasma exhibiting typical exo...
关键词:Intracerebral hemorrhage EXOSOMES Young human plasma Ferroptosis Functional recovery 
Secretive derived from hypoxia preconditioned mesenchymal stem cells promote cartilage regeneration and mitigate joint inflammation via extracellular vesicles被引量:7
《Bioactive Materials》2023年第9期98-112,共15页Yanmeng Yang Yingnan Wu Dahou Yang Shu Hui Neo Nurul Dinah Kadir Doreen Goh Jian Xiong Tan Vinitha Denslin Eng Hin Lee Zheng Yang 
supported by National Medical Research Council of Singapore(MOH-000371-00);the National Research Foundation,Prime Minister’s Office,Singapore under its Campus for Research Excellence and Technological Enterprise(CREATE)program,through Singapore-MIT Alliance for Research and Technology(SMART):Critical Analytics for Manufacturing Personalized-Medicine(CAMP)Inter-Disciplinary Research Group.YY was supported by NUS Research Scholarship.
Secretome derived from mesenchymal stem cells (MSCs) have profound effects on tissue regeneration, which could become the basis of future MSCs therapies. Hypoxia, as the physiologic environment of MSCs, has great pote...
关键词:Hypoxia preconditioned MSCs SECRETOME Extracellular vesicles Cartilage regeneration Joint inflammation 
Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway被引量:2
《Bioactive Materials》2023年第4期75-90,共16页Zhaojie Wang Huiyi Yang Xu Xu Hongxing Hu Yuxin Bai Jian Hai Liming Cheng Rongrong Zhu 
This work was financially supported by the INTERNATIONAL COOPERATION Project of National Natural Science Foundation of China(Grant No.81810001048);the National Natural Science Foundation of China(Grant Nos.81922039,81873994,31727801,82225027 and 82001308);Key Basic Research Projects of Shanghai Science and Technology Commission(Grant No.19JC141470)。
Chronic low back pain and dyskinesia caused by intervertebral disc degeneration(IDD)are seriously aggravated and become more prevalent with age.Current clinical treatments do not restore the biological structure and i...
关键词:Mesenchymal stem cells Layered double hydroxide Chondrogenic differentiation Intervertebral disc degeneration Focal adhesion signaling pathway 
TGF-β1-supplemented decellularized annulus fibrosus matrix hydrogels promote annulus fibrosus repair被引量:11
《Bioactive Materials》2023年第1期581-593,共13页Qiang Wei Dachuan Liu Genglei Chu Qifan Yu Zhao Liu Jiaying Li Qingchen Meng Weishan Wang Fengxuan Han Bin Li 
the funding provided for this study by the National Natural Science Foundation of China(81925027,32130059,31872748,32171350,32101103);Natural Science Foundation of Jiangsu Province(BK20200199);China Postdoctoral Science Foundation(2021M702412);the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Annulus fibrosus(AF)repair remains a challenge because of its limited self-healing ability.Endogenous repair strategies combining scaffolds and growth factors show great promise in AF repair.Although the unique and be...
关键词:Decellularized matrix Annulus fibrosus HYDROGEL TGF-Β1 Tissue repair 
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