State Key Project of Research and Development(2022YFB3804400);National Natural Science Foundation of China(32071334,52333011&51825302);Natural Science Foundation of Chongqing(cstc2021jcyj-cxttX0002 and CSTB2023NSCQ-MSX0074);Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology(Chongqing University);Ministry of Education(CQKLBST-2023-001).
Postmenopausal osteoporosis(PMOP)is a prevalent condition among elderly women.After menopause,women exhibit decreased iron excretion,which is prone to osteoporosis.To design a specific titanium implant for PMOP,we fir...
National Natural Science Foundation of China(U21A20297);Natural Science Foundation of Qingdao(202406).
Hydrogels are promising materials for wound protection,but in wet,or underwater environments,the hydration layer and swelling of hydrogels can seriously reduce adhesion and limit their application.In this study,inspir...
supported by the Fundamental Research Funds for the Central Universities(No.21623310);the Dongguan Science and Technology of Social Development Program(No.20231800939902);the National Natural Science Foundation of China(No.81801907);the Guangdong Basic and Applied Basic Research Foundation(No.2022A1515140171);the Medical Joint Fund of Jinan University(No.YXJC2022011);Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research(No.ZDSYS20230626091402006).
Spinal cord injury(SCI)causes neuroinflammation,neuronal death,and severe axonal connections.Alleviating neuroinflammation,protecting residual cells and promoting neuronal regeneration via endogenous neural stem cells...
National Natural Science Foundation of China projects(81921004,D.K.);National Natural Science Foundation of China projects(32201122,X.D.);National Natural Science Foundation of China projects(82272156,M.Z.);China Postdoctoral Science Foundation(2022M711705 X.D.);Key Military Medical Project(No.BLB21J008,D.K.);Tianjin Natural Science Foundation(C100303 F M.).
Peripheral nerve injuries may result in severe long-gap interruptions that are challenging to repair.Autografting is the gold standard surgical approach for repairing long-gap nerve injuries but can result in prominen...
the National Natural Science Foundation of China(Nos.81891002,81971178,32200806);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA16040701);the Youth Innovation Promotion Association CAS(No.2021319);the Natural Science Foundation of Jiangsu Province(No.BK20210127);the High-level Innovation and Entrepreneurship Talent Introduction Plan of Jiangsu Province.We acknowledge the CapitalBio Technology Inc.(Beijing,China)for RNA sequencing and proteomic sequencing.Schematic in Fig.2A and 6C were created with BioRender.com and were granted publication permission.We acknowledge a kind gift of PEGDA from Prof.Y.Du(Tsinghua University,Beijing,China)and help from PhD candiate WJ.Li in his lab on schematic preparation.
Neural regeneration after spinal cord injury (SCI) closely relates to the microvascular endothelial cell (MEC)- mediated neurovascular unit formation. However, the effects of central nerve system-derived MECs on neova...
supported by National Natural Science Foundation of China(T2222029 and U21A20396);Strategic Priority Research Program of Chinese Academy of Sciences(XDA16020802);CAS Project for Young Scientists in Basic Research(YSBR-012);CAS Engineering Laboratory for Intelligent Organ Manufacturing(KFJ-PTXM-039).
Mechanical force is crucial in the whole process of embryonic development.However,the role of trophoblast mechanics during embryo implantation has rarely been studied.In this study,we constructed a model to explore th...
supported by grants from National Natural Science Foundation of China(81671228);Program for Innovation research group of universities in Chongqing(CXQT19012);Chongqing municipal Science Fund for Distinguished Young Scholars(cstc2019jcyjjqX0030);Science and Technology Innovation Project of Jinfeng Laboratory,Chongqing,China(jfkyjf202203001).
Intracerebral hemorrhage (ICH), as a type of life-threatening and highly disabled disease, has limited therapeutic approaches. Here, we show that exosomes derived from young healthy human plasma exhibiting typical exo...
supported by National Medical Research Council of Singapore(MOH-000371-00);the National Research Foundation,Prime Minister’s Office,Singapore under its Campus for Research Excellence and Technological Enterprise(CREATE)program,through Singapore-MIT Alliance for Research and Technology(SMART):Critical Analytics for Manufacturing Personalized-Medicine(CAMP)Inter-Disciplinary Research Group.YY was supported by NUS Research Scholarship.
Secretome derived from mesenchymal stem cells (MSCs) have profound effects on tissue regeneration, which could become the basis of future MSCs therapies. Hypoxia, as the physiologic environment of MSCs, has great pote...
This work was financially supported by the INTERNATIONAL COOPERATION Project of National Natural Science Foundation of China(Grant No.81810001048);the National Natural Science Foundation of China(Grant Nos.81922039,81873994,31727801,82225027 and 82001308);Key Basic Research Projects of Shanghai Science and Technology Commission(Grant No.19JC141470)。
Chronic low back pain and dyskinesia caused by intervertebral disc degeneration(IDD)are seriously aggravated and become more prevalent with age.Current clinical treatments do not restore the biological structure and i...
the funding provided for this study by the National Natural Science Foundation of China(81925027,32130059,31872748,32171350,32101103);Natural Science Foundation of Jiangsu Province(BK20200199);China Postdoctoral Science Foundation(2021M702412);the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Annulus fibrosus(AF)repair remains a challenge because of its limited self-healing ability.Endogenous repair strategies combining scaffolds and growth factors show great promise in AF repair.Although the unique and be...