PROTEASOME

作品数：158被引量：433H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：邹晓民徐萍田蕊李卉王超更多>>
相关机构：北京大学苏州大学北京协和医学院吉林大学第二医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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20S proteasome and glyoxalase 1 activities decrease in erythrocytes derived from Alzheimer’s disease patients被引量：2
《Neural Regeneration Research》2020年第1期178-183,共6页Hui Lv Gui-Yuan Wei Can-Shou Guo Yu-Feng Deng Yong-Ming Jiang Ce Gao Chong-Dong Jian 
supported by the National Natural Science Foundation of China,No.81860244;the Natural Science Foundation of Guangxi Zhuang Autonomous Region of China,No.2018JJA140311 and 2018GXNSFAA281051;the Basic Ability Enhancement Program for Young and Middle-aged Teachers of Guangxi Zhuang Autonomous Region of China,No.2017KY0516(all to CDJ)
As a result of accumulating methylglyoxal and advanced glycation end products in the brains of patients with Alzheimer’s disease,it is considered a protein precipitation disease.The ubiquitin proteasome system is one...
关键词：20S proteasomal activity Alzheimer’s disease erythrocytes GLYOXALASE 1 H2O2 MALONDIALDEHYDE nerve regeneration total UBIQUITIN 
Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer＇s disease被引量：12
《Neural Regeneration Research》2018年第1期19-25,共7页Isaac G. Onyango 
Alzheimer’s disease （AD） is an increasingly pressing worldwide public-health, social, political and economic concern. Despite significant investment in multiple traditional therapeutic strategies that have achieved...
关键词：Alzheimer＇s disease mitochondria BIOENERGETICS mitochondrial DNA neuroinflammation mitohormesis caloric restriction HYPOMETABOLISM MITOPHAGY mitochondrial biogenesis recombinant-human mitochondrial transcription factor A antioxidants PROTEASOME mitochondrial transcription activator-like effector nucleases clustered regularly interspaced short palindromic repeats/associated protein 9 （CRISPR/Cas9） caloric restriction stem cells 
Modification of ubiquitin C-terminal hydrolase L1 by reactive lipid species: role in neural regeneration and diseases of aging
《Neural Regeneration Research》2016年第6期908-909,共2页Steven H.Graham 
supported in part by NIH R01 NS37459-15
Role of ubiquitin C-terminal hydrolase L1（UCHL1）in brain function：Ubiquitin is used by a variety of cellular systems to tag proteins for transport to various organelles.There are a number of enzymes in the ubiquiti...
关键词：ubiquitin proteasome regeneration Ubiquitin hydrolase Modification synaptic neuronal lipid enzymes 
Targeting BPOZ-2 in Lewy body disease
《Neural Regeneration Research》2016年第6期910-911,共2页Avik Roy 
funded by MJ FOX Foundation Rapid Response Innovation Award Grant to AR
Formation of Lewy body inclusions（LBs）in the substantia nigra（SN）is a very well-characterized pathological hallmark of Parkinson’s disease（PD）.LBs are aggregates of many biologically inactive proteins including...
关键词：Targeting substantia proteasome nigra ubiquitin biologically inactive mitochondria dopamine parkin 
Calcium-dependent proteasome activation is required for axonal neurofilament degradation被引量：2
《Neural Regeneration Research》2013年第36期3401-3409,共9页Joo Youn Park So Young Jang Yoon Kyung Shin Duk Joon Suh Hwan Tae Park 
supported by research funds from Dong-A University,South Korea
Even though many studies have identified roles of proteasomes in axonal degeneration, the mo- lecular mechanisms by which axonal injury regulates proteasome activity are still unclear. In the present study, we found e...
关键词：neural regeneration peripheral nerve injury neurofilament degradation sciatic nerve CALCIUM calpain mitochondria microtubule depolymerization axon axon degeneration neuroregeneration 
Synthetic protease inhibitor-induced inclusions in PC12 cells Potential proteomic characterization of six subunits in the 26S proteasome
《Neural Regeneration Research》2010年第22期1685-1693,共9页Mingxiu Tian Xing'an Li Yingjiu Zhang Yihong Hu Ming Chang Tao Liu Danping Wang Yu Zhang Linsen Hu 
the Science and Technology Commission Foundation of Jilin Province,No.200505200;the Distinguished Professor Foundation of Jilin University,No.450011011204
Proteasome dysfunction during dopaminergic degeneration induces proteolytic stress, and is a contributing factor for the onset and formation of Lewy bodies. Results from our previous studies showed that synthetic prot...
关键词：PC12 cells proteasome inhibitor-induced inclusions proteasome subunit two-dimensional gel peptide mass fingerprints PROTEOMIC 
Proteasome alteration and delayed neuronal death in hippocampal CA1 and dentate gyrus regions following transient cerebral ischemia
《Neural Regeneration Research》2009年第10期744-748,共5页Pengfei Ge Tianfei Luo Jizhou Zhang Haifeng Wang Wenchen Li Yongxin Luan Feng Ling Yi'nan Luo 
Supported by:the Postdoctoral Foundation of China,No.20080440422;International Cooperation G rant,No.20070721;Outstanding Youth Grant of the Science and Technology Department of Jilin Province, No.20080139;a grant from the Science and Technology Department of Changchun City,No.2007128
BACKGROUND： Proteasome dysfunction has been reported to induce abnormal protein aggregation and cell death. OBJECTIVE： To investigate the effect of proteasome changes on delayed neuronal death in CA1 and dentate gyr...
关键词：transient cerebral ischemia neuronal death PROTEASOME 
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