HYPOMETABOLISM

作品数：12被引量：32H指数：3
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相关领域：生物学医药卫生更多>>
相关期刊：《Neural Regeneration Research》《Frontiers of Medicine》《Zoological Research》《Journal of Ocean University of China》更多>>
相关基金：国家自然科学基金更多>>
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Surviving winter on the Qinghai-Xizang Plateau:Extensive reversible protein phosphorylation plays a dominant role in regulating hypometabolism in hibernating Nanorana parkeri
《Zoological Research》2024年第1期1-12,共12页Yong-Gang Niu Deng-Bang Wei Xue-Jing Zhang Ti-Sen Xu Xiang-Yong Li Hai-Ying Zhang Zhi-Fang An Kenneth B.Storey Qiang Chen 
supported by the National Natural Science Foundation of China(32001110);Training Program for Cultivating Highlevel Talents by the China Scholarship Council(2021lxjjw01);Open Project of State Key Laboratory of Plateau Ecology and Agriculture,Qinghai University(2021-KF-004)。
Changes in protein abundance and reversible protein phosphorylation(RPP)play important roles in regulating hypometabolism but have never been documented in overwintering frogs at high altitudes.To test the hypothesis ...
关键词：Nanorana parkeri PROTEOMIC Phosphoproteomic HIBERNATION Reversible protein phosphorylation Metabolism 
Altered O-GlcNAcylation and mitochondrial dysfunction,a molecular link between brain glucose dysregulation and sporadic Alzheimer's disease被引量：5
《Neural Regeneration Research》2023年第4期779-783,共5页Chia-Wei Huang Nicholas C.Rust Hsueh-Fu Wu Gerald W.Hart 
supported by the Georgia Research Alliance and the University of Georgia(to GWH)。
Alzheimer’s disease is a neurodegenerative disease that affected over 6.5 million people in the United States in 2021,with this number expected to double in the next 40 years without any sort of treatment.Due to its ...
关键词：Alzheimer’s disease amyloid beta BRAIN glucose deficiency glucose uptake HYPOMETABOLISM mitochondrial dysfunction neurodegenerative disease neurons O-GlcNAc Tau 
^(18)F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma被引量：1
《Frontiers of Medicine》2021年第6期913-921,共9页Chao Lu Kailiang Wang Fei Meng Yihe Wang Yongzhi Shan Penghu Wei Guoguang Zhao 
supported by the National Natural Science Foundation of China(Nos.81801288,81871009,and 82030037)。
Epileptogenic hypothalamic hamartoma is characterized by intractable gelastic seizures.A systematic analysis of the overall brain metabolic pattern in patients with hypothalamic hamartoma(HH)could facilitate the under...
关键词：hypothalamic hamartoma gelastic seizure fluorodeoxyglucose-positron emission tomography voxel-based morphometry 
Transcriptome and Metabolome Analyses of Sea Cucumbers Apostichopus japonicus in Southern China During the Summer Aestivation Period被引量：2
《Journal of Ocean University of China》2021年第1期198-212,共15页YANG Qiuhua ZHANG Xusheng LU Zhen HUANG Ruifang TRAN Ngoc Tuan WU Jianshao YANG Fuyuan GE Hui ZHONG Chenhui SUN Qian ZHOU Chen LIN Qi 
supported by the Science and Technology Program of Fujian Province(Nos.2018R1003-1 and 2019R1013-5);the Special Funds for Marine and Fishery Structure Adjustment(No.2020HYJG02);the Marine Economy Innovation and Area Development Demonstration Project of Fujian Province(No.FJHJF-L-2020-4)。
Aestivation is a common strategy of sea cucumbers(Apostichopus japonicus)in response to high-temperature conditions.Previous studies have individually investigated the immune and physiological alterations at the aesti...
关键词：AESTIVATION Apostichopus japonicus HYPOMETABOLISM fatty acid metabolism carbohydrate hydrolysis PHAGOCYTOSIS 
Functional impact of microRNA regulation n models of extreme stress adaptation被引量：7
《Journal of Molecular Cell Biology》2018年第2期93-101,共9页Kyle K. Biggar Kenneth B. Storey 
When confronted with severe environmental stress, some animals are able to undergo a substantial reorganization of their cellular environment that enables long-term survival. One molecular mechanism of adaptation that...
关键词：HYPOMETABOLISM METABOLISM temperature metabolic rate depression stress response 
Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer＇s disease被引量：12
《Neural Regeneration Research》2018年第1期19-25,共7页Isaac G. Onyango 
Alzheimer’s disease （AD） is an increasingly pressing worldwide public-health, social, political and economic concern. Despite significant investment in multiple traditional therapeutic strategies that have achieved...
关键词：Alzheimer＇s disease mitochondria BIOENERGETICS mitochondrial DNA neuroinflammation mitohormesis caloric restriction HYPOMETABOLISM MITOPHAGY mitochondrial biogenesis recombinant-human mitochondrial transcription factor A antioxidants PROTEASOME mitochondrial transcription activator-like effector nucleases clustered regularly interspaced short palindromic repeats/associated protein 9 （CRISPR/Cas9） caloric restriction stem cells 
Up-regulation of Long Non-coding RNA TUG1 in Hibernating Thirteen-lined Ground Squirrels被引量：1
《Genomics, Proteomics & Bioinformatics》2016年第2期113-118,共6页Jacques J.Frigault Daneck Lang-Ouellette Pier Morin Jr. 
supported by a Discovery Grant from the Natural Sciences and Engineering Research Council of Canada (Grant No. RGPIN/402222-2012) awarded to PJM
Mammalian hibernation is associated with multiple physiological, biochemical, and molecular changes that allow animals to endure colder temperatures. We hypothesize that long non-coding RNAs（lnc RNAs）, a group of no...
关键词：HIBERNATION HYPOMETABOLISM Cold adaptation Non-codiag RNAs lncRNAs 
Modulation of Gene Expression in Key Survival Pathways During Daily Torpor in the Gray Mouse Lemur, Microcebus murinus
《Genomics, Proteomics & Bioinformatics》2015年第2期111-118,共8页Kyle K.Biggar Cheng-Wei Wu Shannon N.Tessier Jing Zhang Fabien Pifferi Martine Perret Kenneth B.Storey 
supported by a Discovery grant from the Natural Sciences and Engineering Research Council (NSERC) of Canada (Grant No. 6793);a grant from the Heart and Stroke Foundation of Canada (Grant No. G-140005874) to KBS. KBS holds the Canada Research Chair in Molecular Physiology;SNT, KKB, and CWW all held NSERC postgraduate scholarships
A variety of mammals employ torpor as an energy-saving strategy in environments of marginal or severe stress either on a daily basis during their inactive period or on a seasonal basis during prolonged multi-day hiber...
关键词：Daily torpor Primate hypometabolism PPAR gamma coactivator Ferritin Chaperone proteins 
Induction of Antioxidant and Heat Shock Protein Responses During Torpor in the Gray Mouse Lemur, Microcebus murinus被引量：1
《Genomics, Proteomics & Bioinformatics》2015年第2期119-126,共8页Cheng-Wei Wu Kyle K.Biggar Jing Zhang Shannon N.Tessier Fabien Pifferi Martine Perret Kenneth B.Storey 
supported by a Discovery grant from the Natural Sciences and Engineering Research Council (NSERC) of Canada (Grant No. 6793);a grant from the Heart and Stroke Foundation of Canada (Grant No. G-140005874) to KBS. KBS holds the Canada Research Chair in Molecular Physiology;CWW, KKB, and SNT all held NSERC postgraduate scholarships
A natural tolerance of various environmental stresses is typically supported by various cytoprotective mechanisms that protect macromolecules and promote extended viability. Among these are antioxidant defenses that h...
关键词：Heat shock proteins Antioxidant capacity Primate hypometabolism Stress response 
The physiology of artificial hibernation
《Journal of Clinical & Translational Research》2015年第2期19-34,共16页Marcel C.Dirkes Thomas M.van Gulik Michal Heger 
Incomplete understanding of the mechanisms responsible for induction of hibernation prevent translation of natural hibernation to its artificial counterpart.To facilitate this translation,a model was developed that id...
关键词：anapyrexia hypometabolic agents HYPOMETABOLISM natural HIBERNATION TORPOR thermoneutral zone HYPOXIA body temperature thermal convection ARRHENIUS law 
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