PROTEOMIC

作品数：225被引量：569H指数：13
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Insights from a proteomic atlas of human Alzheimer's disease brain tissue
《Neural Regeneration Research》2025年第3期799-800,共2页Tomas Kavanagh Eleanor Drummond 
supported by the Bluesand Foundation;TDM Foundation;Faculty of Medicine and Health, University of Sydney (FMH EMCR Emerging Star Grant), NIH (P01AG060882) to ED。
There is an urgent need to identify new drug targets for Alzheimer's disease(AD). While new immunotherapies show promise, clinical benefit appears low, and side effects are high. A greater understanding of the disease...
关键词：ALZHEIMER CLINICAL driving 
Circulating proteomic biomarkers for diagnosing sporadic amyotrophic lateral sclerosis:a cross-sectional study被引量：5
《Neural Regeneration Research》2024年第8期1842-1848,共7页Lu He Qinming Zhou Chaoyang Xiu Yaping Shao Dingding Shen Huanyu Meng Weidong Le Sheng Chen 
supported by the grants from Shanghai Shuguang Plan Project,No.18SG15(to SC);Shanghai Outstanding Young Scholars Project;Shanghai Talent Development Project,No.2019044(to SC);Medical-engineering cross fund of Shanghai Jiao Tong University,No.YG2022QN009(to QZ);the National Natural Science Foundation of China,No.82201558(to QZ)。
Biomarke rs are required for the early detection,prognosis prediction,and monitoring of amyotrophic lateral sclerosis,a progressive disease.Proteomics is an unbiased and quantitative method that can be used to detect ...
关键词：amyotrophic lateral sclerosis cathelicidin-related antimicrobial peptide HEMOGLOBIN label-free quantitative proteomics multi-protein combined diagnostic panel serum biomarkers talin-1 translationally-controlled tumor protein ZYXIN 
Quantitative proteomic and phosphoproteomic analyses of the hippocampus reveal the involvement of NMDAR1 signaling in repetitive mild traumatic brain injury被引量：1
《Neural Regeneration Research》2023年第12期2711-2719,共9页Zhicheng Tian Zixuan Cao Erwan Yang Juan Li Dan Liao Fei Wang Taozhi Wang Zhuoyuan Zhang Haofuzi Zhang Xiaofan Jiang Xin Li Peng Luo 
funded by the National Natural Science Foundation of China,Nos.82171363(to PL),82171321(to XL),82171458(to XJ);the Youth Nova Program of Shaanxi,No.2021KJXX-19(to PL)。
The cumulative damage caused by repetitive mild traumatic brain injury can cause long-term neurodegeneration leading to cognitive impairment.This cognitive impairment is thought to result specifically from damage to t...
关键词：cognitive impairment Grin1 HIPPOCAMPUS learning memory N-METHYL-D-ASPARTATE N-methyl-D-aspartate receptor 1 phosphoproteomic PROTEOMIC repetitive mild traumatic brain injury(rmTBI) secondary injury 
Altered proteomic expression in the prefrontal cortex of morphine-addicted rats
《Neural Regeneration Research》2011年第4期300-303,共4页Ye Yang Chunyan Zhang Han Liu Bin Wang Haiying Lin Lisha Wu 
sponsored by a grant from the Sichuan Provincial Education Department(Influence of AGS3 on"reversible protein phosphorylation"in cortical neu-rons of morphine-addicted rats),No.2005B016
The prefrontal cortex is involved in the regulation and control of substance addiction-related cognitive, behavioral, and emotional changes. The present study identified prefrontal cortex protein profiles in morphine-...
关键词：ADDICTION MORPHINE prefrontal cortex PROTEOME 2-dimensional gel electrophoresis 
Synthetic protease inhibitor-induced inclusions in PC12 cells Potential proteomic characterization of six subunits in the 26S proteasome
《Neural Regeneration Research》2010年第22期1685-1693,共9页Mingxiu Tian Xing'an Li Yingjiu Zhang Yihong Hu Ming Chang Tao Liu Danping Wang Yu Zhang Linsen Hu 
the Science and Technology Commission Foundation of Jilin Province,No.200505200;the Distinguished Professor Foundation of Jilin University,No.450011011204
Proteasome dysfunction during dopaminergic degeneration induces proteolytic stress, and is a contributing factor for the onset and formation of Lewy bodies. Results from our previous studies showed that synthetic prot...
关键词：PC12 cells proteasome inhibitor-induced inclusions proteasome subunit two-dimensional gel peptide mass fingerprints PROTEOMIC 
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