SELF-ADAPTIVE

作品数：245被引量：532H指数：9
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Self-adaptive pyroptosis-responsive nanoliposomes block pyroptosis in autoimmune inflammatory diseases被引量：1
《Bioactive Materials》2024年第6期272-286,共15页Kaiwang Xu Huang Yang Jinghua Fang Kaijie Qiu Haotian Shen Guanrui Huang Qiangqiang Zheng Canlong Wang Tengjing Xu Xinning Yu Jiajie Wang Yunting Lin Jiacheng Dai Yuting Zhong Hongyun Song Sunan Zhu Siheng Wang Zhuxing Zhou Guang Yang Zhengwei Mao Zongyou Pan Xuesong Dai 
sustained by the National Natural Science Foundation of China(82072512,52273152,22161132027);Zhejiang Provincial Natural Science Foundation of China(LY23H060013,LY21H070001,LY20H160044,LBY21H060003).
Nanoliposomes have a broad range of applications in the treatment of autoimmune inflammatory diseases because of their ability to considerably enhance drug transport.For their clinical application,nanoliposomes must b...
关键词：Nanoliposome PYROPTOSIS Autoimmune inflammatory diseases Responsive drug delivery ANTI-INFLAMMATION 
A suture-free, shape self-adaptive and bioactive PEG-Lysozyme implant for Corneal stroma defect repair and rapid vision restoration被引量：2
《Bioactive Materials》2023年第11期1-15,共15页Hang Zhou Shaohua Zhang Miao Lei Yixin Cai Honglei Wang Jianguo Sun Jingyuan Cui Changsheng Liu Xue Qu 
the National Natural Science Foundation of China(31922041,11932012,32171341);National key research and development program(2021YFB3800800),the 111 project(B14018);the Science and Technology Innovation Project and Excellent Academic Leader Project of Shanghai Science and Technology Committee(21S31901500,21XD1421100);the Scientific and Innovative Action Plan of Shanghai(No.19441900600);the Natural Science Foundation of Shanghai(No.19ZR1408300);the China Postdoctoral Science Foundation(D100-5R-22114);the Shanghai Sailing Program(23YF1409700)are acknowledged.
limitation of donor tissue shortage clinically. In addition, suturing-needed transplantation potentially causes postoperative complications. Herein, we design a PEG-Lysozyme injective hydrogel as a suture-free, shape ...
关键词：Injective implant Suture free Shape self-adaptive Intraocular pressure endurance Foraging behavioral test 
An anti-bacterial porous shape memory self-adaptive stiffened polymer for alveolar bone regeneration after tooth extraction被引量：3
《Bioactive Materials》2023年第3期450-463,共14页Weijun Zhang Meilin Yu Yongqiang Cao Zihan Zhuang Kunxi Zhang Dong Chen Wenguang Liu Jingbo Yin 
National Natural Science Foundation of China(No.52173131,51773113).
The regeneration of alveolar bone after tooth extraction is critical for the placement of dental implants.Developing a rigid porous scaffold with defect shape adaptability is of great importance but challenging for al...
关键词：Shape memory scaffold Alveolar bone regeneration Stiffened SELF-ADAPTIVE ANTI-BACTERIAL 
Wound microenvironment self-adaptive hydrogel with efficient angiogenesis for promoting diabetic wound healing被引量：7
《Bioactive Materials》2023年第2期561-573,共13页Zijian Shao Tianyu Yin Jinbo Jiang Yang He Tao Xiang Shaobing Zhou 
supported by the National Natural Science Foundation of China(Nos.52103186,51725303,52033007);the Fundamental Research Funds for the Central Universities(Nos.2682020ZT84,2682021ZTPY008).
Neovascularization is critical to improve the diabetic microenvironment,deliver abundant nutrients to the wound and promote wound closure.However,the excess of oxidative stress impedes the healing process.Herein,a sel...
关键词：Wound microenvironment Self-adaptive hydrogel MMP-9 responsive ANGIOGENESIS Diabetic wound healing 
Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing被引量：15
《Bioactive Materials》2022年第11期1-17,共17页Wanyi Zhou Zhiguang Duan Jing Zhao Rongzhan Fu Chenhui Zhu Daidi Fan 
This work was supported by the National key Research and devel-opment program of China(2019YFA0905200);the National Natural Science Foundation of China(21878247,21808184);Key Program of the National Natural Science Foundation of China(21838009).
Chronic diabetic wounds are an important healthcare challenge. High concentration glucose, high level of matrix metalloproteinase-9 (MMP-9), and long-term inflammation constitute the special wound environment of diabe...
关键词：Dual-responsive Temperature-sensitive Shape self-adaptive hydrogels Diabetic wound healing 
Enzymatically-degradable hydrogel coatings on titanium for bacterial infection inhibition and enhanced soft tissue compatibility via a self-adaptive strategy被引量：4
《Bioactive Materials》2021年第12期4670-4685,共16页Jin Leng Ye He Zhang Yuan Bailong Tao Ke Li Chuanchuan Lin Kun Xu Maowen Chen Liangliang Dai Xuemin Li Tony Jun Huang Kaiyong Cai 
This work was financially supported by the National Natural Science Foundation of China(51825302,21734002&52021004);the State Key Project of Research and Development(Grant No.2016YFC1100300&2017YFB0702603).
Ideal percutaneous titanium implants request both antibacterial ability and soft tissue compatibility.ZnO structure constructed on titanium has been widely proved to be helpful to combat pathogen contamination,but the...
关键词：TITANIUM ZnO Hydrogel coatings ANTI-BACTERIA FIBROBLASTS Soft tissue compatibility 
Intelligent nanogels with self-adaptive responsiveness for improved tumor drug delivery and augmented chemotherapy被引量：1
《Bioactive Materials》2021年第10期3473-3484,共12页Xin Li Helin Li Changchang Zhang Andrij Pich Lingxi Xing Xiangyang Shi 
This research was financially supported by the Sino-German Center for Research Promotion(GZ1505);National Natural Science Foundation of China(81801704 and 81761148028);the Science and Technology Commission of Shanghai Municipality(19XD1400100);Shanghai Sailing Program(18YF1415300);the China Scholarship Council(for X.Li);X.Shi also thanks the support by FCT-Fundaçao para a Ciencia e a Tecnologia through the CQM Base Fund-UIDB/00674/2020;Programmatic Fund-UIDP/00674/2020;by ARDITI-Agencia Regional para o Desenvolvimento da Investigaçao Tecnologia e Inovaçao,through the project M1420-01-0145-FEDER-000005-Centro de Química da Madeira-CQM+(Madeira 14-20 Program).
For cancer nanomedicine,the main goal is to deliver therapeutic agents effectively to solid tumors.Here,we report the unique design of self-adaptive ultrafast charge-reversible chitosan-polypyrrole nanogels(CH-PPy NGs...
关键词：Ultrafast charge conversion NANOGELS Active transportation Deep tumor penetration Enhanced antitumor activity 
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