This work was supported by the National Natural Science Foundation of China(81922032,31900660,81788101);the Young Elite Scientist Sponsorship Program by CAST(2018QNRC001).
Background:Small RNAs(sRNAs)extensively mediate gene-specific chromatin regulation in lower organisms.As a dominant type of functional sRNAs in mature mammals,microRNAs mainly regulate gene expression at posttranscrip...
grants from the National Natural Science Foundation of China (91435203 and 31991222);the Major Program of Guangdong Basic and Applied Basic Research (2019B030302006)。
Dear Editor,CRISPR(clustered regularly interspaced short palindromic repeats)/Cas genome editing is a powerful tool for introducing specific mutations in organisms including plants.The system is composed of a nuclease...
We thank Chunmei Li,Matthew Harris,Erdem Sendinc,and David Valle-Garcia for insightful advice.Y.S.is supported by BCH funds.R.I.G.is a recipient of the NCI Outstanding investigator Award(R35 CA232115-01);E.A.O.was supported by the Pew Latin American Fellows Program and by a Damon Runyon Fellowship(DRG-2378-19);Y.X.is supported by NIH grants(R01GM088342 and R01GM121827);Y.S.is an American Cancer Society Research Professor.
Dear Editor,Protein coding mRNAs and non-coding RNAs are extensively modifed by chemical modifications,'including methylation of the N^6position of adenosine(m^6A).^2While mRNA internal m^6A methylation is mediated by...