SPECIFICITY

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Structural genomics of the human dopamine receptor system
《Cell Research》2023年第8期604-616,共13页Peiyu Xu Sijie Huang Brian E.Krumm Youwen Zhuang Chunyou Mao Yumu Zhang Yue Wang Xi-Ping Huang Yong-Feng Liu Xinheng He Huadong Li Wanchao Yin Yi Jiang Yan Zhang Bryan L.Roth H.Eric Xu 
the National Key R&D Programs of China(2018YFA0507002)’Shanghai Municipal Science and Technology Major Project(2019SHZDZX02 and XDB08020303)to H.E.X.;the National Key Basic Research Program of China(2019YFA0508800)‘the Key R&D Projects of Zhejiang Province(2021C03039);Fundamental Research Funds for the Central Universities(2019XZZX001-01-06)to Yan Z.;the Zhejiang Province Natural Science Fund for Excellent Young Scholars(LR22C050002);the National Natural Science Foundation of China(32100959)to C.M.;the National Natural Science Foundation of China(31770796);the National Science and Technology Major Project(2018ZX09711002)to Y.J.;grants from the NIMH Psychoactive Drug Screening Program to X.-P.H.,Y.L.,B.L.R.,and RO1MH112205 to B.E.K.and B.L.R.The Special Research Assistant Project of Chinese Academy of Sciences to Youwen Z.
The dopaminergic system,including five dopamine receptors(D1R to D5R),plays essential roles in the central nervous system(CNS);and ligands that activate dopamine receptors have been used to treat many neuropsychiatric...
关键词：DOPAMINE SPECIFICITY SYSTEM 
Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response被引量：18
《Cell Research》2022年第6期530-542,共13页Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou 
supported by grants from the National Key R&D Program of China(2016YFA0500304);the National Nature Science Foundation of China(NSFC)(81773052,81572806,81802854,81802853);the Guangzhou Science Technology and Innovation Commission(201607020038);the Natural Science Foundation of Guangdong Province(2017A030308007);the Guangdong Innovative and Entrepreneurial Research Team Program(2016ZT06S638);the Leading Talents Program of Guangdong Province(2016LJ06S464).
Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect ...
关键词：IMMUNOTHERAPY SPECIFICITY TCR 
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor被引量：5
《Cell Research》2020年第12期1098-1108,共11页Wen Sun Li-Nan Chen Qingtong Zhou Li-Hua Zhao Dehua Yang Huibing Zhang Zhaotong Cong Dan-Dan Shen Fenghui Zhao Fulai Zhou Xiaoqing Cai Yan Chen Yan Zhou Sarina Gadgaard Wijnand JCvan der Velden Suwen Zhao Yi Jiang Mette MRosenkilde HEric Xu Yan Zhang Ming-Wei Wang 
the National Natural Science Foundation of China(81872915(M.W.W.),81922071(Y.Zhang),81773792(D.Y.),81973373(D.Y.),21704064(Q.Z.),31770796(YJ.)and 31971178(S.Z.));the National Science&Technology Major Project of China—Key New Drug Creation and Manufacturing Program(2018ZX09735-001(M.W.W.),2018ZX09711002-002-005(D.Y.)and 2018ZX09711002-002-002(YJ.));the National Key Basic Research Program of China(2018YFA0507000(M.W.W.and S.Z.)and 2019YFA0508800(Y.Zhang));the Shanghai Municipal Science and Technology Major Project(2019SHZDZX02(H.E.X.));the Ministry of Science and Technology of China Major Project(XDB08020303(H.E.X.));Zhejiang Province Science Fund for Distinguished Young Scholars(LR19H310001(Y.Zhang));Fundamental Research Funds for Central Universities(2019XZZX001-01-06(Y.Zhang));Shanghai Science and Technology Development Fund(18ZR1447800(L.H.Z.));Young Innovator Association of CAS(2018325(L.H.Z.));SA-SIBS Scholarship Program(L.H.Z.and D.Y.);Fudan-SIMM Joint Research Fund(FU-SIMM-20174003(L.H.Z.and M.W.W.))and Novo Nordisk-CAS Research Fund grant(NNCAS-2017-1-CC(D.Y.)).
Glucagon-like peptides(GLP-1 and GLP-2)are two proglucagon-derived intestinal hormones that mediate distinct physiological functions through two related receptors(GLP-1R and GLP-2R)which are important drug targets for...
关键词：SPECIFICITY SPITE INSIGHT 
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling被引量：20
《Cell Research》2020年第9期745-762,共18页Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts 
This work was supported by VIB TechWatch funding,Scientific Fund for Research-Flanders(FWO)grants to D.Lambrechts(G065615N),a Stichting tegen Kanker(STK)grant to D.Lambrechts(FAF-C/2016/876),a VIB Grand Challenge grant to D.Lambrechts;The computational resources used in this work were provided by the Flemish Supercomputer Center(VSC),funded by the Hercules Foundation and the Flemish Government,Department of Economy,Science and Innovation(EWI).
The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what ext...
关键词：ORGANS SPECIFICITY CONCLUSION 
Coding GPCR-G protein specificity
《Cell Research》2017年第10期1193-1194,共2页Sebastian GB Furness Patrick M Sexton 
G protein-coupled receptors （GP- CRs） are ubiquitous gatekeepers of cellular response and signal predomi- nantly by recruitment and activation of G proteins. In a recent paper in Nature, Flock et aL use large-scale ...
关键词：编码蛋白 G蛋白偶联受体 异性 蛋白相互作用 细胞反应 生物信息 CRS 数据库 
Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters被引量：3
《Cell Research》2014年第3期267-277,共11页You Yu Mingze Zhou Franziska Kirsch Congqiao Xu Li Zhang Yu Wang Zheng Jiang Na Wang Jun Li Thomas Eitinger Maojun Yang 
The energy-coupling factor （ECF） transporters are multi-subunit protein complexes that mediate uptake of transition-metal ions and vitamins in about 50% of the prokaryotes, including bacteria and archaea. Biological...
关键词：energy-coupling factor transporter nickel and cobalt transporters crystal structure 
Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans被引量：3
《Cell Research》2010年第8期886-898,共13页Ying Yang Lulu Hu Ping Wang Haifeng Hou Yan Lin Yi Liu Ze Li Rui Gong Xiang Feng Lu Zhou Wen Zhang Yuhui Dong Huirong Yang Hanqing Lin Yiqin Wang Charlie Degui Chen Yanhui Xu 
Histone lysine methylation can be removed by JmjC domain-containing proteins in a sequence- and methylationstate-specific manner. However, how substrate specificity is determined and how the enzymes are regulated were...
关键词：HISTONE methylation DEMETHYLASE structure PHD JMJC 
Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans被引量：2
《Cell Research》2010年第8期899-907,共9页Hanqing Lin Yiqin Wang Yanru Wang Feng Tian Pu Pu Yi Yu Hailei Mao Ying Yang Ping Wang Lulu Hu Yan Lin Yi Liu Yanhui Xu Charlie Degui Chen 
H3K9me2 and H3K27me2 are important epigenetic marks associated with transcription repression, while H3K4me3 is associated with transcription activation. It has been shown that active and repressive histone methylation...
关键词：KDM7A DEMETHYLASE H3K9me2 H3K27me2 PHD JMJC HISTONE methylation 
A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis被引量：14
《Cell Research》2010年第2期138-153,共16页Lin Teng Jian Zhao Feifei Wang Lan Ma Gang Pei 
Supplementary information is linked to the online version of the paper on the Cell Research website.Acknowledgments We thank Dr David Westaway （University of Alberta） for TgCRND8 mice, Dr David Baltimore （California Institute of Technology） for lentiviral constructs, Dr Raphael Kopan （Washington University） for the plasmid of myc-tagged NotchAE and Dr Johan Lundkvist （Karolinska Institutet） for the plasmid of Gal4-driven luciferase reporter gene, the plasmid of APP/CTFI3-GVP and NAE-GVP. We appreciate Shunmei Xin, Shan Chen and Xianglu Zeng for their technical assistance. We thank all members of the lab for sharing reagents and advice. This research was supported by the Ministry of Science and Technology （2009ZX09103-684）, the National Natural Science Foundation of China （30621091, 30625014, 30623003, 30871285 and 90713047）, the Shanghai Municipal Commission for Science and Technology （07PJ14099 and 09JC1416400）, and the Chinese Academy of Sciences （2007KIP204）.
Dysregulation of β-site APP-cleaving enzyme （BACE） and/or γ-secretase leads to anomalous production of amyloid-β peptide （Aβ） and contributes to the etiology of Alzheimer＇s disease （AD）. Since these secreta...
关键词：G protein-coupled receptor Alzheimer＇s disease BACE Γ-SECRETASE Notch 
Dual-specificity histone demethylase KIAA1718 （KDM7A） regulates neural differentiation through FGF4被引量：16
《Cell Research》2010年第2期154-165,共12页Chengyang Huang Yang Xiang Yanru Wang Xia Li Longyong Xu Ziqi Zhu Ting Zhang Qingqing Zhu Kejing Zhang Naihe Jing Charlie Degui Chen 
Supplementary information is linked to the online version of the paper on the Cell Research website.Acknowledgments We thank Anning Lin （The University of Chicago） for the critical reading of the paper, members in the Chen lab for technical help, the cell biology and molecular biology core facilities for confocal study and Q-PCR, and Shanghai Biochip Co Ltd. for microarray analysis. The H3K27me2 antibody was kindly provided by Li Tang （Fudan University） and Thomas Jenuwein （Research Institute of Molecular Pathology, The Vienna Biocenter）. This work was supported by the National Basic Research Program of China （2007CB957900, 2006CB943902, 2007CB947101, 2008KR0695, 2009CB941100, 2005CB522704）, the Chinese Academy of Sciences （KSCX2-YW-R-04）, the National Natural Science Foundation of China （90919026, 30870538,30623003, 30721065, 30830034, 90919046）, the Shanghai Pujiang Program （0757S11361）, the Shanghai Key Project of Basic Science Research （06DJ14001, 06DZ22032, 08DJ1400501）, and the Council of Shanghai Municipal Government for Science and Technology （088014199）.
Dimethylations of histone H3 lysine 9 and lysine 27 are important epigenetic marks associated with transcription repression. Here, we identified KIAA1718 （KDM7A） as a novel histone demethylase specific for these two...
关键词：histone demethylase KIAA1718 KDM7A neural differentiation FGF4 
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