SYSTEMS_BIOLOGY

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Constraints on the utilization of cereal straw in lactating dairy cows:A review from the perspective of systems biology被引量：8
《Animal Nutrition》2022年第2期240-248,共9页Bing Wang Huizeng Sun Diming Wang Hongyun Liu Jianxin Liu 
the National Basic Research Program of the China Ministry of Science and Technology(2011CB100801);the National Natural Science Foundation of China(No.31472121,31729004);the China Agriculture(Dairy)Research System(CARS-36).
Cereal straw,a human inedible crop byproduct,can be used as a roughage source in ruminants.However,the nutrition density and palatability are very low,limiting its efficient utilization in animal production.This revie...
关键词：Amino acid metabolism Cereal straw Glucose utilization METABOLITES Rumen microbiome 
Identification of Key Genes for the Ultrahigh Yield of Rice Using Dynamic Cross-tissue Network Analysis被引量：5
《Genomics, Proteomics & Bioinformatics》2020年第3期256-270,共15页Jihong Hu Tao Zeng Qiongmei Xia Liyu Huang Yesheng Zhang Chuanchao Zhang Yan Zeng Hui Liu Shilai Zhang Guangfu Huang Wenting Wan Yi Ding Fengyi Hu Congdang Yang Luonan Chen Wen Wang 
the National Basic Research Program of China(Grant No.2013CB835200);the National Key R&D Program of China(Grant No.2017YFA0505500);the Key Grant of Yunnan Provincial Science and Technology Department(Grant No.2013GA004);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB13040700);the National Natural Science Foundation of China(Grant Nos.11871456 and 31771476);the Shanghai Municipal Science and Technology Major Project(Grant No.2017SHZDZX01);the Open Research Fund of State Key Laboratory of Hybrid Rice(Wuhan University,Grant No.KF201806),China。
Significantly increasing crop yield is a major and worldwide challenge for food supply and security.It is well-known that rice cultivated at Taoyuan in Yunnan of China can produce the highest yield worldwide.Yet,the g...
关键词：Dynamic cross-tissue(DCT) Systems biology RNA-SEQ Ultrahigh yield Rice 
Gene regulatory network stabilized by pervasive weak repressions: micro RNA functions revealed by the May–Wigner theory被引量：3
《National Science Review》2019年第6期1176-1188,共13页Yuxin Chen Yang Shen Pei Lin Ding Tong Yixin Zhao Stefano Allesina Xu Shen Chung-I Wu 
supported by the National Natural Science Foundation of China(31730046 and 91731301);the National Basic Research Program(973 Program)of China(2014CB542006);the 985 Project(33000–18841204);National Institute of Health,USA(5 R01 GM058686-09 to WU,Chung-I)
Food web and gene regulatory networks(GRNs)are large biological networks,both of which can be analyzed using the May-Wigner theory.According to the theory,networks as large as mammalian GRNs would require dedicated ge...
关键词：micro RNAs network stability CANALIZATION May-Wigner theory systems biology RNA crosstalk 
A primer on recent developments in cancer immunotherapy, with a focus on neoantigen vaccines被引量：1
《Journal of Cancer Metastasis and Treatment》2018年第1期10-33,共24页Taku A.Tokuyasu Jian-Dong Huang 
This work was supported by a National Basic Research Program of China(973 Program,No.2014CB745202);the Shenzhen Peacock Team Project(No.KQTD2015033117210153);the Shenzhen Science and Technology Innovation Committee Basic Science Research Grants(No.JCYJ20170413154523577,No.JCYJ20150629151046896);the Guangdong Natural Science Funds for Distinguished Young Scholar Grant(No.S2013050016987).
Cancer immunotherapy has now been conclusively shown to be capable of producing durable responses for a substantial number of patients.Adoptive cell transfer and checkpoint blockade therapies in particular both demons...
关键词：IMMUNOTHERAPY cancer vaccine IMMUNOINFORMATICS precision medicine combination therapy theoretical models systems biology 
Deciphering the pharmacological mechanism of the Chinese formula Huanglian-Jie-Du decoction in the treatment of ischemic stroke using a systems biology-based strategy被引量：5
《Acta Pharmacologica Sinica》2015年第6期724-733,共10页Yan-qiong ZHANG Song-song WANG Wei-liang ZHU Yan MA Fang-bo ZHANG Ri-xin LIANG Hai-yu XU Hong-jun YANG 
Aim： Huanglian-Jie-Du decoction （HUDD） is an important multiherb remedy in TCM, which is recently demonstrated to be effective to treat ischemic stroke. Here, we aimed to investigate the pharmacological mechanisms ...
关键词：Traditional Chinese Medicine Chinese herbal formula ischemic stroke Huanglian-Jie-Du decoction systems biology network pharmacology 
Outlier deletion based improvement on the StOMP algorithm for sparse solution of large-scale underdetermined problems被引量：2
《Science China(Information Sciences)》2014年第9期238-251,共14页ZHANG WanHong ZHOU Tong HUANG BoXue 
supported in part by National Basic Research Program of China (973)(Grant No. 2012CB316504);National Natural Science Foundation of China (Grant Nos. 61174122,61021063);Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20110002110045)
StOMP algorithm is well suited to large-scale underdetermined applications in sparse vector estimations. It can reduce computation complexity and has some attractive asymptotical statistical properties.However,the est...
关键词：stagewise orthogonal matching pursuit sparse solution linear underdetermined equations systems biology outlier deletion 
Comparative systems biology between human and animal models based on next-generation sequencing methods
《Zoological Research》2013年第S02期35-41,共7页Yu-Qi ZHAO Gong-Hua LI Jing-Fei HUANG 
This work was supported by the National Natural Science Foundation of China(31123005);the Chinese Academy of Sciences(Y002731071);the National Basic Research Program of China(2009CB941300)。
Animal models provide myriad benefits to both experimental and clinical research.Unfortunately,in many situations,they fall short of expected results or provide contradictory results.In part,this can be the result of ...
关键词：Animal models Comparative systems biology Next-generation sequencing RNA-SEQ CHIP-SEQ 
Comparative systems biology between human and animal models based on next-generation sequencing methods
《Zoological Research》2013年第2期J0001-J0007,共7页Yu-Qi ZHAO Gong-Hua LI Jing-Fei HUANG 
supported by the National Natural Science Foundation of China (31123005);the Chinese Academy of Sciences (Y002731071);the National Basic Research Program of China (2009CB941300)
Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the resul...
关键词：Animal models Comparative systems biology Next-generation sequencing RNA-SEQ ChlP-seq 
Gene Network Analysis and Functional Studies of Senescence-associated Genes Reveal Novel Regulators of Arabidopsis Leaf Senescence被引量：22
《Journal of Integrative Plant Biology》2012年第8期526-539,共14页Zhonahai Li Jinying Peng Xing Wen Hongwei Guo 
supported by grants from the Ministry of Science and Technology of China (2009CB119101);the National Science Foundation of China (91017010) to H.G
Plant leaf senescence has been recognized as the last phase of plant development, a highly ordered process regulated by genes known as senescence associated genes （SAGs）. However, the function of most of SAGs in reg...
关键词：ARABIDOPSIS leaf senescence SAG PHYTOHORMONE systems biology. 
Application of systems biology to the study of chronic kidney disease被引量：2
《Chinese Medical Journal》2012年第14期2603-2609,共7页CAO Yu-han LU Lin-li ZHANG Jian-dong LIU Bi-cheng 
Chronic kidney disease （CKD） is a major public health problem that affects about 10% of the general population. Current approaches to characterize the category and progression of CKD are normally based on renal hist...
关键词：＇ systems biology chronic kidney disease  microarray analysis  genome-wide association study serial analysis of gene expression 
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