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Apatinib regulates the glycolysis of vascular endothelial cells through PI3K/AKT/PFKFB3 pathway in hepatocellular carcinoma
《World Journal of Gastroenterology》2025年第11期135-152,共18页Yi Wu Bin-Bin Xie Bing-Liang Zhang Qing-Xin Zhuang Shi-Wei Liu Hong-Ming Pan 
Supported by the National Natural Science Foundation of China,No.82100542 and No.81802842.
BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent and aggressive malignancy in the Chinese population;the severe vascularization by the tumor makes it difficult to cure.The high incidence and poor survival rates ...
关键词：Apatinib Hepatocellular carcinoma Vascular endothelial cells GLYCOLYSIS Phosphatidylinositol 3-kinase Protein kinase B 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase 3 
Adoptive transfer of Pfkfb3-disrupted hematopoietic cells to wild-type mice exacerbates diet-induced hepatic steatosis and inflammation被引量：1
《Liver Research》2020年第3期136-144,共9页Xin Guo Bilian Zhu Hang Xu Honggui Li Boxiong Jiang Yina Wang Benrong Zheng Shannon Glaser Gianfranco Alpini Chaodong Wu 
This work was supported in part by the Hickam Endowed Chair,Gastroenterology,Medicine,Indiana University and the Indiana University Health e Indiana University School of Medicine Strategic Research Initiative,the Research Career Scientist to Dr.Alpini from the United States Department of Veteran’s Affairs,Biomedical Laboratory Research and Development Service and National Institutes of Health(NIH)grants DK054811,DK110035,and DK076898 to Drs.G.Alpini and S.Glaser.In addition,this work was supported in whole or in part by grants from the American Diabetes Association(ADA)(1-10-BS-76 to C.Wu);the National Institutes of Health(DK095828 and DK124854 to C.Wu).
Background and objectives:Hepatic steatosis and inflammation are key characteristics of non-alcoholic fatty liver disease(NAFLD).However,whether and how hepatic steatosis and liver inflammation are differentially regu...
关键词：6-Phosphofructo-2-kinase/fructose-2 6-biphosphatase 3(Pfkfb3/iPfk2) Hematopoietic cells Hepatic steatosis INFLAMMATION MACROPHAGES 
Role of PFKFB3 and CD163 in Oral Squamous Cell Carcinoma Angiogenesis被引量：4
《Current Medical Science》2019年第3期410-414,共5页Ji-jia LI Xiao-he MAO Tian TIAN Wei-ming WANG Tong SU Can-hua JIANG Chuan-yu HU 
This study was supported by the National Natural Science Foundation of China (No.81702708 and No.81873717).
6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3), an enzyme producing fructose 2, 6-bisphosphate (F-2, 6-BP), serves as a switch to activate phosphofructokinase-1, and is a critical enzyme for endotheli...
关键词：6-phosphofructo-2-kinase/fructose-2 6-biphosphatase 3 ANGIOGENESIS CD163 CD31 
Structure and Expression Analyses of a Gene Encoding Fructose-6-Phosphate, 2-Kinase/Fructose-2,6-Bisphosphatase from Maize被引量：1
《Acta Botanica Sinica》2003年第4期466-471,共6页王东 杜喜玲 张红生 钱晓茵 杨金水 翟虎渠 
教育部博士点基金 ( 2 0 0 10 30 70 0 3)~~
A full-length cDNA encoding fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase from maize (Zea mays L.) was cloned by the methods of reverse transcription-polymerase chain reaction (RT-PCR) and rapid amplifica...
关键词：maize fructose-2 6-bisphosphate fructose-6-phosphate 2-kinase/fructose-2 6-bisphosphatase seed vigor 
Characterization of the separate kinase domain of chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
《Progress in Natural Science:Materials International》2001年第8期20-28,共9页杨齐衡 朱峥 李林 
Project supported by the National Natural Science Foundation of China (Grant No. 39870187 and 39525005), Chinese Academy of Sciences (STZ-2-01 and KJ952-S1-13) and Shanghai Research Center of Life Sciences.
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase consists of two distinct domains which catalyze the synthesis and hydrolysis of fructose-2, 6-bisphosphate, respectively. In this work the p...
关键词：6-phosphofructo-2-kinase fructose-2 6-bisphosphatase glutathione S-TRANSFERASE fusion pro-tein kinetic property. 
A study on the separate bisphosphatase domain of chicken liver 6-phosphofructo-2- kinase/ fructose- 2,6- bisphosphatase
《Progress in Natural Science:Materials International》1997年第4期120-123,共4页李林 姚炜哲 麦嵩 许根俊 
Project supported by the National Natural Science Foundation of China and Climbing Plan.
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase （6PF-2-K/Fru-2, 6-P2ase; ATP: D-fructose-6-phosphate 2-phosphotransferase/D-fructose-2, 6-bisphosphatase 2-phosphohydrolase, EC...
关键词：fructose-2 6-bisphosphatase expression SITE-DIRECTED mutagenesis. 
Preparation of monoclonal antibodies against chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and their effects on enzyme activities
《Science China(Life Sciences)》1996年第4期342-349,共8页李同元 丁建芳 李林 许根俊 
Project supported by Climbing Project of the State Science and Technology Commission of China and the National Natural Science Foundation of China.
The effects of the monoclonal antibodies (McAbs) directed against chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PF-2-K/Fru-2, 6-P2ase) on the structure and function of the enzyme were studied. U...
关键词：6-phosphofructo-2-kinase/fructose-2 6-bisphosphatase fructose 2 6-bisphosphatase domain MONOCLONAL antibody. 
Preliminary crystallographic analysis of recombinant chicken liver fructose-2,6-bisphosphatase被引量：1
《Science China Chemistry》1996年第1期7-10,共4页包素锦 万柱礼 常文瑞 桂璐璐 梁栋材 凌嵩 李林 许根俊 Simon J. Pilkis 
Project supported by the Science Foundation of Chinese Academy of Sciences (KZ85-04), the Climbing Project of the State Commission of Science and Technology;the National Natural Science Foundation of China.
The bisphosphatase domain of chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphos-phosphatase was expressed in high yield Escherichia coli and purified to homogeneity. Single crystals of chicken liver bisphopha...
关键词：chicken liver 6-phosphofructo-2-kinase/fructose-2 6-bisphosphatase fructose-2 6-bisphosphatase crystallization. 
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