TUBEIMOSIDE

作品数：7被引量：36H指数：5
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相关领域：医药卫生更多>>
相关作者：王强贾耿王穗暖杨伊林夏锡伟更多>>
相关机构：苏州大学附属第三医院第二军医大学第四军医大学西京医院杭州医学院更多>>
相关期刊：《临床神经外科杂志》《Acta Pharmacologica Sinica》《药学服务与研究》《Science Bulletin》更多>>
相关基金：国家自然科学基金更多>>
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Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR被引量：9
《Acta Pharmaceutica Sinica B》2021年第10期3134-3149,共16页Xiaojia Liu Mingxiao Yin Jingwen Dong Genxiang Mao Wenjian Min Zean Kuang Peng Yang Lu Liu Na Zhang Hongbin Deng 
supported by grants from National Natural Science Foundation of China(81973366,81773782,81903695 and 82003792);CAMS Innovation Fund for Medical Sciences(2016I2M-1-011,China);National Mega-project for Innovative Drugs(2019ZX09721-001,China);Chinese Pharmaceutical Association-Yiling Pharmaceutical Innovation Fund for Biomedicine(GL-1-B04-20180366,China)。
Programmed cell death ligand 1(PD-L1)/programmed cell death protein 1(PD-1)cascade is an effective therapeutic target for immune checkpoint blockade(ICB)therapy.Targeting PD-L1/PD-1 axis by small-molecule drug is an a...
关键词：PD-L1 Immune checkpoint blockade Transcription factor EB LYSOSOME MTOR 
Tubeimoside-1, a triterpenoid saponin, induces cytoprotective autophagy in human breast cancer cells in vitro via Akt-mediated pathway被引量：13
《Acta Pharmacologica Sinica》2019年第7期919-928,共10页Shi-long Jiang Yi-di Guan Xi-sha Chen Peng Ge Xin-luan Wang Yuan-zhi Lao Song-shu Xiao Yi Zhang Jin-ming Yang Xiao-jun Xu Dong-sheng Cao Yan Cheng 
grants from the National Natural Science Foundation of China (Nos. 81422051, 81472593, and 31401208);the Hunan Natural Science Foundation of China (No. 2016JJ1020).
Autophagy, a form of cellular self-digestion by lysosome, is associated with various disease processes including cancers, and modulating autophagy has shown promise in the treatment of various malignancies. A number o...
关键词：tubeimoside-1 AUTOPHAGY apoptosis AKT BREAST cancer cells 
Tubeimoside-1 induces oxidative stress-mediated apoptosis and GJG1 phase arrest in human prostate carcinoma cells in vitro被引量：7
《Acta Pharmacologica Sinica》2016年第7期950-962,共13页Jing-bo YANG Muhammad KHAN Yang-yang HE Min YAO Yong-ming LI Hong-wen GAO Tong-hui MA 
Aim： Tubeimoside-1 （TBMS1）, a triterpenoid saponin extracted from the Chinese herbal medicine Bolbostemma paniculatum （Maxim） Franquet （Cucurbitaceae）, has shown anticancer activities in various cancer cell lin...
关键词：TBMS1 human prostate cancer apoptosis Go/Gi phase arrest oxidative stress mitochondrial dysfunction ER stress Z-VAD-FMK NAC SB203580 SP600125 salubrinal 
土贝母苷甲通过上调FADD/caspase-8/caspase-3的表达促进人胶质瘤U251细胞凋亡被引量：6
《临床神经外科杂志》2014年第6期426-429,共4页贾耿 夏锡伟 彭亚 王强 邵耐远 王穗暖 杨伊林 
国家自然科学基金资助项目(31071046;81302197)
目的研究土贝母苷甲(TBMSⅠ)诱导人胶质瘤U251细胞凋亡及其可能的内在机制。方法四甲基偶氮唑蓝比色法(MTT法)检测不同浓度的土贝母苷甲对U251细胞增殖的影响。Hoechst 33258荧光染色观察不同浓度土贝母苷甲处理U251细胞后细胞核形态的...
关键词：土贝母苷甲 胶质瘤 凋亡 tubeimoside-1 
中药土贝母中环形双糖链皂苷活性成分的分离和鉴定被引量：4
《药学服务与研究》2005年第3期216-223,共8页汤海峰 易杨华 李玲 孙鹏 王忠壮 赵越平 
目的:研究中药土贝母中的环形双糖链皂苷活性成分。方法:采用稻瘟霉模型生物活性追踪方法,应用多种色谱技术进行分离,根据波谱解析和化学手段鉴定其结构。结果:分离并鉴定了4个具有诱导稻瘟霉菌丝变形活性的环形双糖链皂苷:tubeimoside...
关键词：土贝母 环形双糖链皂苷 TUBEIMOSIDE Ⅴ 稻瘟霉 细胞毒性 溶血作用 
A New Cyclic Bisdesmoside from Tubers of Bolbostemma paniculatum被引量：6
《Chinese Chemical Letters》2005年第4期479-482,共4页HaiFengTANG YangHuaYI ShuYuZHANG PengSUN LingLI DaZhengZHOU 
The structure of tubeimoside V (1), a new cyclic bisdesmoside, isolated from tubers of Bolbostemma paniculatum (Tu Bei Mu), was established by means of 2D NMR spectral and chemical methods. Compound 1 has inter-saccha...
关键词：Bolbostemma paniculatum cyclic bisdesmoside triterpenoid saponin tubeimoside V. 
POTENT INHIBITORY EFFECTS OF TUBEIMOSIDE 1 ISOLATED FROM THE BULB OF Bolbostemma paniculatum (MAXIM)FRANQUET ON INFLAMMATORY EAR OEDEMA AND TUMOR PROMOTION IN MICE被引量：1
《Chinese Science Bulletin》1992年第7期602-606,共5页马润娣 于立坚 王永清 HOYOKU NISHINO JUNKO TAKAYASU 
The research work was partly carried out in the Department of Biochemistry Kyoto Prefectural University of Medicine Japan
Numerous attempts have been made to select compounds that might reduce the incidence of cancer. Previously we have found out that several kinds of natural and
关键词：TUBEIMOSIDE 1 anti-inflammatory activity ANTITUMOR promoting action. 
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