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作品数：656被引量：1797H指数：16
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Efficacy of Ganshuang granules(肝爽颗粒)on non-alcoholic fatty liver and underlying mechanism:a network pharmacology and experimental verification
《Journal of Traditional Chinese Medicine》2024年第1期122-130,共9页ZHI Guoguo SHAO Bingjie ZHENG Tianyan JI Shaoxiu LI Jingwei DANG Yanni LIU Feng WANG Dong 
the Chengdu University of Traditional Chinese Medicine:Application of A Mouse Model to Explore the Mechanism of Therapeutic Action of Safranin in Type 2 Diabetes Mellitus(No.YXRC2018003)。
OBJECTIVE:To investigate the potential pharmacological mechanisms of Ganshuang granules(肝爽颗粒,GSG)in treating non-alcoholic fatty liver(NAFLD).METHODS:All the active components and targets of GSG were retrieved fro...
关键词：fatty liver ALCOHOLIC network pharmacology models ANIMAL phosphatidylinositol 3-kinase proto-oncogene proteins c-akt signal transduction Ganshuang granules 
Mechanism underlying Fanmugua(Fructus Caricae)leaf multicomponent synergistic therapy for anemia:data mining based on hematopoietic network
《Journal of Traditional Chinese Medicine》2023年第3期542-551,共10页JIA Lihong TIE Defu FAN Zhaohui CHEN Dan CHEN Qizhu CHEN Jun BO Huaben 
Supported by the National Natural Science Foundation of China:Study on the Effect of Intestinal Bacteria on the Hematopoietic Component Absorption Mechanism of Danggui Buxue Tang(No.82104514);Guangzhou Municipal Science and Technology Project:Based on the Multilevel Pharmacodynamic Model to Explore the Material Basis of Regulation of Erythroid Progenitor Cell Differentiation by Danggui Buxue Tang(No.201707010441);Innovation and University Promotion Project of Guangdong Pharmaceutical University(No.2017KCXTD020)。
OBJECTIVE:To investigate the underlying mechanism of Fanmugua(Fructus Caricae) Leaf(CPL) multicomponent synergistic therapy for anemia.METHODS:The components were identified in the literature.Six databases were search...
关键词：ANEMIA data mining network pharmacology molecular docking simulation Carica papaya(Fructus Caricae)Leaf synergistic effect 
Therapeutic mechanisms of integrated traditional Chinese and conventional medicine underlying its treatment of precancerous lesions of gastric cancer被引量：7
《Journal of Traditional Chinese Medicine》2022年第6期1023-1028,共6页XU Qing WANG Yang LI Zhongyu YAN Jiaxing ZHAO Yingpan WANG Ping WEN Yandong 
Supported by National Key Technology R&D Program during the 13th Five-Year Plan Period Evidence-based evaluation and efficacy mechanism of Jianpi-Huoxue principle in the treatment of gastric precancerous lesions (No. 2017YFC1700601);Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences:Screening of miRNAs in different pathological stages of gastric mucosal “inflammation-cancer” transformation and its correlation with symptom patterns (No. CI2021A01005)。
China has a high incidence of gastric cancer. Secondary prevention of gastric cancer is a major public health problem that must be solved urgently. Modern medicine focuses on the pathogenesis of precancerous lesions o...
关键词：stomach neoplasms precancerous lesions MECHANISMS integrative medicine REVIEW 
Mechanism underlying efficacy of Shugan Sanjie decoction(疏肝散结汤) on plasma cell mastitis,based on network pharmacology and experimental verification被引量：8
《Journal of Traditional Chinese Medicine》2022年第3期400-407,共8页QIAO Nan WANG Qinnan MA Chaoqun CHEN Dexuan CHEN Haidong LU Yaoyao 
Supported by Clinical Medicine Project of Nantong University for Youth(No.2019LQ018);Youth Project of Nantong Municipal Health Committee(No.QA2020013);the Grants-in-Aid for Scientific Research from the Ministry of Nantong Science and Technology(No.MSZ18254)
OBJECTIVE:To investigate the mechanism underpinning the effeicay of Shugan Sanjie decoction(疏肝散结汤,SGSJD)on plasma cell mastitis(PCM)based on network pharmacology,and to verify it through in vitro.METHODS:Traditio...
关键词：plasma cells MASTITIS network pharmacology molecular mechanism Shugan Sanjie decoction 
Mechanism underlying the effect of Liujunzi decoction(六君子汤)on advanced-stage non-small cell lung cancer in patients after first-line chemotherapy被引量：2
《Journal of Traditional Chinese Medicine》2022年第1期108-115,共8页XIN Xiaoli WANG Guodong HAN Ru JIANG Yi LIU Chang LIU Lingshuang XU Zhenye 
Supported by the National Natural Science Foundation of China(NSFC)(81903270)(Therapeutic Effect and Mechanism of Embryonic Lung Progenitor Cell Transplantation on Silicosis Fibrosis)and(81703987)(Study on the Synergistic Effect and Mechanism of Yiqi Yangyin Jiedu Prescription Combined with Anti-CTLA-4 Mab in Inducing Anti-Lung Cancer Immune Response);Jinan Science and Technology Project(201907019)(Study of Therapy and Mechanisms of Embryonic Lung Stem Cell Transplantation on Silicosis Fibrosis);the Shanghai Science and Technology Commission(19401971200)(a Multicenter Randomized Controlled Study on Improving Prognosis of Patients With StageⅢA Non-Small Cell Lung Cancer By Liu Jiaxiang's Prescription for Qi-Yin Differentiation and Treatment);the Emerging Frontier Technology Joint Research Project of Shanghai Shenkang Hospital Development Center(SHDC12018131)(a Multicenter Randomized Controlled Double-Blind Study on the Prevention and Treatment of Postoperative Recurrence and Metastasis Of StageⅢA Non-Small Cell Lung Cancer By Liu Jiaxiang Qi-Yin Differentiation Method);the Major Project of Scientific Research and Innovation Plan of Shanghai Education Commission(No.2017-01-07-00-10-E00064)(Study on the Mechanism of Feyanning Prescription Against Lung Cancer Growth and Metastasis Derived from Jingqi Theory);Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine(AJ-37)(Clinical Study of Yiqi Yangyin Jiedu Prescription Combined With Oxitinib in the Treatment of Advanced Lung Cancer With T790M Mutation)and(AJ-41)(Clinical Study of“Decubitus Chiropractic Therapy”in the Treatment of Vertebral Artery Type Cervical Spondylosis);National Traditional Chinese Medicine Clinical Research Base Long-Yi-Xue-Zhe Nurturing Plan(LYTD-64)(Mechanism of Reversal of EGFR-Tkis Resistance Induced By HGF in Tumor-Bearing H1975-SCID Mice Based on Huachansu Injection)。
OBJECTIVE:To further clarify the anticancer mechanisms of Liujunzi decoction(六君子汤)and provide possible targets for the treatment of advanced-stage nonsmall cell lung cancer(NSCLC)by re-analyzing differential gene ...
关键词：CARCINOMA non-small-cell lung antineoplastic agents computational biology RNA small interfering Liujunzi decoction 
Mechanism underlying effect of Chaihu Shugan San(柴胡疏肝散)on major depressive disorder:a network pharmacology-based study被引量：4
《Journal of Traditional Chinese Medicine》2021年第2期338-348,共11页MU Jie ZHANG Shuang TANG Feifei LIU Shuling ZHANG Qianyi DU Qianlei WANG Xueqian WANG Qingguo CHENG Fafeng 
Supported by the General Program of National Natural Science Foundation of China(No.81774122);Young Teachers Project of Beijing University of Chinese Medicine(No.2017-JYB-JS-002),College Level Project of Beijing University of Chinese Medicine(No.2019-JYB-XS-002);Projects of Sichuan Administration of Traditional Chinese Medicine(No.2020JC0035);Xinglin Scholar Project of Chengdu University of Traditional Chinese Medicine(No.BSH2020016)。
OBJECTIVE:To investigate the mechanism underpinning the effect of Chaihu Shugan San(柴胡疏肝散,CHSGS)on major depressive disorder(MDD).METHODS:We searched the compound components of from seven herbal ingredients of CH...
关键词：Depressive disorder major PHARMACOLOGY Chaihu Shugan San 
Possible mechanisms underlying treatment of Alzheimer’s disease with Traditional Chinese Medicine: active components, potential targets and synthetic pathways of Bulao Elixir被引量：8
《Journal of Traditional Chinese Medicine》2020年第3期484-496,共13页Ren Beida Cheng Fafeng Wang Xueqian Wan Yuxiang Ji Wenting Du Xin Zhang Shuang Liu Shilling Ma Chongyang Xiong Yiliang Hao Gaoting Wang Qingguo 
Supported by the National Natural Science Foundation of China(No.2010071420012;1000071220002;2010072120020;2010072220008 and 20180072020005);the Classical Prescription Basic Research Team of Beijing University of Chinese Medicine。
OBJECTIVE: To elucidate the mechanisms underlying the treatment of Alzheimer’s disease(AD) with Traditional Chinese Medicine(TCM), by examining the active components, potential targets and synthetic pathways of Bulao...
关键词：Alzheimer disease PHARMACOLOGY Components TARGETS Pathway Bulao Elixir 
Possible mechanism underlying analgesic effect of Tuina in rats may involve piezo mechanosensitive channels within dorsal root ganglia axon被引量：11
《Journal of Traditional Chinese Medicine》2018年第6期834-841,共8页Song Pengfei Lin Zhigang Zhu Qingguang Jiang Shichao Zhang Hao Cheng Yanbin Sun Wuquan Wu Zhiwei Zhou Xin Lv Zhizhen Fang Min 
Supported by High Level Innovation Team of Traditional Chinese Medicine Peak Plateau Subject(No.30304114316);Study on the Core Technical Specifications and Clinical Evaluation of Guided Exercise Therapy Combined with Acupoints Application in the Prevention of Chronic Fatigue Syndrome(No.2015468003-1);the National Natural Science Foundation of China(No.81603710);the National Natural Science Foundation of China(No.8150151117);Natural Science Foundation of Fujian Province(No.2017J01828);Major Disease Clinical Skills Upgrading Project of Shanghai Shen-kang Hospital Development Center(No.16CR1023A)
OBJECTIVE: To demonstrate the analgesic effect of Tuina mainly from mechanically sensitive ion channels in peripheral myelinated nerve fibers.METHODS: A total of 40 healthy and pathogen-free adult male Sprague-Dawley ...
关键词：TUINA GANGLIA SPINAL HYPERALGESIA Mechansensitiveion channels 
Mechanism underlying treatment of diabetic kidney disease using Traditional Chinese Medicine based on theory of Yin and Yang balance被引量：11
《Journal of Traditional Chinese Medicine》2018年第5期797-802,共6页Piao Yuanlin Yin Dehai 
Supported by the National Natural Science Foundation of China,No.81573921;Beijing Scientific and Technological Development Project for Traditional Chinese Medicine,No.JJ2015-55
The pathogenic mechanism of diabetic kidney disease(DKD) is complex. The development of DKD cannot be fully explained by a single mechanism.Traditional Chinese Medicine(TCM) has been applied extensively for the treatm...
关键词：DIABETIC KIDNEY disease Traditional Chinese Medicine YIN and Yang theory 
Twirling reinforcing-reducing manipulation--central mechanism underlying antihypertensive effect on spontaneous hypertension in rats被引量：6
《Journal of Traditional Chinese Medicine》2018年第3期391-398,共8页Guo Qiulei Liu Qingguo Sun Dongmei Nie Binbin 
Supported by the National Natural Science Foundation of China(Use PET Brain Imaging Technology to Study the Acupuncture Manipulation of Twirling Reinforcing-Reducing Regulation in Spontaneously Hypertensive Rats by Central Integration Signaling Network Construction,No.8157150840)
OBJECTIVE: To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation(TRRM) might be the central mechanism underlying the action.METHODS: In the study,^(18) F-2-...
关键词：Twirling reinforcing reducing method HYPERTENSION Blood pressure Positron-Emission to-mography CENTRAL MECHANISM 
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