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作品数：298被引量：718H指数：11
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Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders
《Neural Regeneration Research》2025年第8期2302-2303,共2页Asma Boulksibat Alessandra Tempio Barbara Bardoni 
The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular processes.In the brain,these p...
关键词：formation processes finally 
Stereoselective synthesis of 2-deoxy-α-C-glycosides from glycals
《Chinese Chemical Letters》2024年第12期422-426,共5页Hongjin Shi Guoyin Yin Xi Lu Yangyang Li 
supported by grants from the Fundamental Research Funds for Central Universities(No.2042021kf0190)。
2-Deoxy-α-C-Glycosides are a significant class of carbohydrates found in numerous bioactive molecules and medicines.Developing a concise strategy for the assembly of theseα-configured C-glycosides is crucial in the ...
关键词：Nickel catalysis STEREOSELECTIVITY 2-Deoxy-α-C-glycosides Glycals Cross-coupling reaction 
Stereoselective Synthesis of 2-Deoxy-α-N-Glycosides from Glycals with 1,4,2-Dioxazol-5-ones
《Chinese Journal of Chemistry》2024年第18期2147-2152,共6页Zhenpeng Shen Guoyin Yin Yangyang Li 
supported by the National Natural Science Foundation of China(22122107).
The synthesis of N-glycosides has received significant attention due to their crucial role in carbohydrate chemistry.Despite considerable advancements developed in the construction of N-glycosides,methods for the ster...
关键词：2-Deoxy-α-N-glycosides Nickel catalysis STEREOSELECTIVITY GLYCALS HYDROAMINATION Amides Glycosylation Alkenes ComprehensiveSummary 
Design of antiviral AGO2-dependent short hairpin RNAs
《Virologica Sinica》2024年第4期645-654,共10页Yuanyuan Bie Jieling Zhang Jiyao Chen Yumin Zhang Muhan Huang Leike Zhang Xi Zhou Yang Qiu 
supported by the National Key R&D Program of China(2023YFC2305900 to Y.Q.and X.Z.);the National Natural Science Foundation of China(U21A20423 to X.Z.,82172269 to Y.Q.and 82222028 to Y.Q.).
The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective antivirals.RNA interference(RNAi)is a sequence-specific gene silencing mechanism that is triggered by sm...
关键词：AgshRNA Antiviral strategy Machine learning model 
PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton,modulating emotional behavior被引量：1
《Zoological Research》2024年第3期535-550,共16页Laidong Yu Fangfang Zeng Mengshu Fan Kexuan Zhang Jingjing Duan Yalu Tan Panlin Liao Jin Wen Chenyu Wang Meilin Wang Jialong Yuan Xinxin Pang Yan Huang Yangzhou Zhang Jia-Da Li Zhuohua Zhang Zhonghua Hu 
supported by the National Natural Science Foundation of China(82171506 and 31872778);Discipline Innovative Engineering Plan(111 Program)of China(B13036);Key Laboratory Grant from Hunan Province(2016TP1006);Department of Science and Technology of Hunan Province(2021DK2001,Innovative Team Program 2019RS1010);Innovation-Driven Team Project from Central South University(2020CX016);Hunan Hundred Talents Program for Young Outstanding Scientists。
Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain function.Synaptic abnormalities,such as defects in the density and morphology of posts...
关键词：Synapse development Dendritic spine Mood disorder Actin cytoskeleton Animal behavior 
The risk of prostate cancer on incidental finding of an avid prostate uptake on 2-deoxy-2-[^(18)F]fluoro-D-glucose positron emission tomography/computed tomography for non-prostate cancer-related pathology:A single centre retrospective study
《Asian Journal of Urology》2024年第1期33-41,共9页Anthony Franklin Troy Gianduzzo Boon Kua David Wong Louise McEwan James Walters Rachel Esler Matthew J.Roberts Geoff Coughlina John W.Yaxley 
Objective:To review the risk of prostate cancer(PCa)in men with incidentally reported increased intraprostatic uptake at 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography(18F-FDG PET/CT)...
关键词：Prostatecancer Positionemission tomography Multiparametric magneticresonance imaging Prostatebiopsy 
Aconite aqueous extract inhibits the growth of hepatocellular carcinoma through CCL2-dependent enhancement of natural killer cell infiltration
《Journal of Integrative Medicine》2023年第6期575-583,共9页Kang-di Yang Xu Zhang Ming-cong Shao Li-na Wang 
funded by the National Natural Science Foundation of China(No.81774244).
Objective:Aconite is a traditional Chinese herbal medicine that has been found to inhibit the development of liver cancer;however,its exact molecular mechanisms in this process remain unclear.This study explores how a...
关键词：ACONITE Natural killer cell Tumor infiltration Chemokine CC chemokine ligand 2 HEPATOMA 
Highly Stereoselective Synthesis of 2-Azido-2-Deoxyglycosides via Gold-Catalyzed S_(N)2 Glycosylation被引量：1
《CCS Chemistry》2023年第12期2799-2807,共9页Yongliang Zhang Xu Ma Liming Zhang 
the National Institutes of Health(grant nos.U01GM125289 and R35GM139640)for financial support;the National Science Foundation(grant no.MRI-1920299)for the acquisition of two Bruker NMR instruments.
Highly stereoselective synthesis of 2-azido-2-deoxyglucosides and 2-azido-2-deoxygalactosides is achieved via a gold-catalyzed S_(N)2 glycosylation.The glycosyl donors feature a designed 1-naphthoate leaving group con...
关键词：aminosugar GLYCOSYLATION 1 2-cis-glycosidic linkage gold catalysis directing group 
WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice
《Neuroscience Bulletin》2023年第9期1333-1347,共15页Dan Xu Yiqiang Zhi Xinyi Liu Le Guan Jurui Yu Dan Zhang Weiya Zhang Yaqing Wang Wucheng Tao Zhiheng Xu 
This work was supported by the National Natural Science Foundation of China(31970920,31921002,and 31430037).
Brain size abnormality is correlated with an increased frequency of autism spectrum disorder(ASD)in offspring.Genetic analysis indicates that heterozygous mutations of the WD repeat domain 62(WDR62)are associated with...
关键词：WDR62 MICROCEPHALY Autism spectrum disorder SYNAPSE Retinoic acid 
YBX2-dependent stabilization of oocyte mRNA through a reversible sponge-like cortical partition
《Cell Research》2023年第8期640-643,共4页Zhihua Zhang Ruyi Liu Hongbin Zhou Yuxi Luo Jian Mu Jing Fu Tianyu Wu Biaobang Chen Qing Sang Lei Wang 
the National Natural Science Foundation of China(82288102);the National Key R&D Program for Young Scientists(2022YFC2702300);the National Key R&D Program of China(2021YFC2700100);the National Natural Science Foundation of China(32130029,82171643,81971450,82001538,81971382).
Dear Editor,Oocyte meiotic maturation and early embryogenesis occur in the absence of transcription and rely on maternal mRNA stored in oocytes.Inmice,thetranscription is subsequently silenced from the late germinal v...
关键词：PARTITION STABILIZATION SPONGE 
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