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相关机构：北京大学第二军医大学厦门大学哈尔滨医科大学更多>>
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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway
《Neural Regeneration Research》2025年第11期3245-3258,共14页Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu 
supported by the National Nature Science Foundation of China,No.81471308(to JL);the Innovative Leading Talents of Liaoning Province,No.XLYC1902031(to JL);Science and Technology Projects in Liaoning Province,No.2022-BS-238(to CH);Young Top Talents of Liaoning Province,No.XLYC1907009(to LW);Dalian Science and Technology Innovation Fund,No.2018J11CY025(to JL)。
Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem ce...
关键词：behavior EXOSOME extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT) 
EWSR1-PSMC5 fusion gene variously activating autophagy in drug resistance of osteosarcoma:A novel gene fusion model report and mechanism research
《Genes & Diseases》2025年第3期7-10,共4页Qing Pan Wenbo Yang Fuhua Huang Wei Wu Zengwu Shao Zhicai Zhang 
supported by the National Natural Science Foundation of China(No.82072979).
Sarcoma is a kind of mesenchymal malignant tumor and often has poor chemotherapy response.There are many reasons for the insensitivity of sarcomas to chemotherapy,among which genetic changes are important.As a common ...
关键词：AUTOPHAGY mesenchymal malignant tumor fusion mode drug resistance ewsr psmc fusion gene gene alterationgene fusion OSTEOSARCOMA genetic changes 
Unsaponifiable matter from walnut oil ameliorate memory deficits and mitochondrial dysfunction in aging mice via activating Nrf2 signaling pathway
《Food Science and Human Wellness》2025年第3期1127-1138,共12页Dan Hong Xiao Xiao Aijin Ma Zhou Chen Siting Li Junxia Xia Yiling Tian Yingmin Jia 
supported by the National Key Research and Development Program(2022YFD1600402);Hebei Provincial Major Science and Technology Achievement Transformation Project(21287101Z);Hebei Provincial Innovation and Entrepreneurship Team Project(215A7102D)。
Aging is an inevitable biological phenomenon that involves a multitude of physiological alterations.Dietary interventions are being considered as potential strategies for delaying age-related dysfunction.Unsaponifiabl...
关键词：Unsaponifiable matter Memory impairment mitochondrial dysfunctions Nrf2 signaling pathway Antioxidant stress 
Metastatic pancreatic cancer with activating BRAF V600E mutations:A case report
《World Journal of Clinical Cases》2025年第16期52-59,共8页Fang Li Feng Shen 
Supported by Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province.
BACKGROUND Pancreatic cancer(PC)is a highly malignant tumor that is resistant to chemotherapy,radiotherapy and immunotherapy.Combination chemotherapy regimens are the standard first-line regimens for metastatic diseas...
关键词：Pancreatic cancer BRAF gene mutation Targeted therapy Prognosis Case report 
Activating lithium storage in 2D CaSi_(2) anode via enhancing pseudocapacitive properties with oxygen modification engineering
《Nano Research》2025年第4期199-206,共8页Yongzheng Zhang Lu Sun Kailin Yang Youwang Ye Liang Zhan Qi Wei Jianan Gu 
supported partially by project of the National Natural Science Foundation of China(Nos.62474064 and 52102203);the Fundamental Research Funds for the Central Universities(No.2024MS082);the NCEPU“Double First-Class”Program.
Silicon(Si)has emerged as a promising anode material for lithium-ion batteries(LIBs)due to its extremely high theoretical capacity of 4200 mAh·g^(-1).However,its practical application is limited by several critical c...
关键词：two-dimensional(2D)CaSi_(2)O_(x) Si anode volume change PSEUDOCAPACITIVE surface modification lithium storage 
Chitosan oligosaccharide enhances the anti-cancer effects of 5-fluorouracil on SNU-C5 colorectal cancer cells by activating ERK
《Oncology Research》2025年第4期873-884,共12页JI-SU HAN HYE-JIN BOO JIN WON HYUN HEESANG SONG IN-YOUB CHANG SANG-PIL YOON 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Korea government(2021R1F1A1063023);by the Ministry of Education(RS-2023-00270936).
Background:Chitosan oligosaccharide(COS)is the major degradation product of chitosan by enzymatic processes.COS,with complete water solubility,exerts significant biological effects,including anti-cancer activity.We in...
关键词：Chitosan oligosaccharide(COS) Colorectal cancer(CRC) 5-Fluorouracil(5-FU) ERK(Extracellular signal-regulated protein kinase) 
Mitophagy Promotes Hair Regeneration by Activating Glutathione Metabolism
《Research》2025年第1期854-869,共16页Dehuan Wang Jingwei Jiang Mengyue Wang Ke Li Huan Liang Nian'ou Wang Weiwei Liu Miaomiao Wang Siyi Zhou Man Zhang Yang Xiao Xinyu Shen Zeming Li Wang Wu Xia Lin Xiao Xiang Qiaoli Xie Wanqian Liu Xun Zhou Qu Tang Wei Zhou Li Yang Cheng-Ming Chuong Mingxing Lei 
supported by the National Key Research and Development Program of China(2023YFC2508200);the National Natural Science Foundation of China(82373509,82003384,and 82203960);Fundamental Research Funds for the Central Universities(2022CDJYGRH-003 and 2023CDJKYJH066);the Natural Science Foundation of Chongqing(CSTB2023JXJL-YFX0028);Chongqing Talents:Exceptional Young Talents Project(cstc2021ycjh-bgzxm0197);Inheritance and Innovation Team of TCM Treatment of Immune Diseases,Scientific Research Foundation from Chongqing University(02210011044110);Research Horizontal Projects of Chongqing University(H20231432 and H20230936),China;C.-M.C.is supported by a research contract(GR1035751)between USC and CMU and US NIH grant R37 AR060306.
Mitophagy maintains tissue homeostasis by self-eliminating defective mitochondria through autophagy.How mitophagy regulates stem cell activity during hair regeneration remains unclear.Here,we found that mitophagy prom...
关键词：mitochondrial activity glutathione metabolism probetransmission electron microscopyand tissue homeostasis hair regeneration stem cell activity 
N6-methyladenosine methyltransferase Wilms tumor 1-associated protein impedes diabetic wound healing through epigenetically activating DNA methyltransferase 1
《World Journal of Diabetes》2025年第3期232-242,共11页Ren-Jie Xiao Tian-Jiao Wang Dan-Yin Wu Shui-Fa Yang Hai Gao Pei-Dong Gan Yang-Yan Yi You-Lai Zhang 
BACKGROUND Diabetic wound injury is a significant and common complication in individuals with diabetes.N6-methyladenosine(m6A)-related epigenetic regulation is widely involved in the pathogenesis of diabetes complicat...
关键词：Diabetic wound healing N6-methyladenosine Wilms tumor 1-associated protein DNA methyltransferase 1 Human umbilical vein endothelial cells 
Magnolol inhibits appetite and causes visceral fat loss through Growth/differentiation factor-15(GDF-15)by activating transcription factor 4-CCAAT enhancer binding proteinγ-mediated endoplasmic reticulum stress responses
《Chinese Journal of Natural Medicines》2025年第3期334-345,共12页Keru Cheng Yanyun Zhou Yilong Hao Shengyun Wu Nanping Wang Peng Zhang Yinfang Wang 
supported by the National Natural Science Foundation of China(Nos.82171552 and 82170479);the Natural Science Foundation of Shanghai Ctiy(No.21ZR1457500);the Science and Technology Bureau of Shanghai Putuo District(No.ptkwws202102).
Magnolol,a compound extracted from Magnolia officinalis,demonstrates potential efficacy in addressing metabolic dysfunction and cardiovascular diseases.Its biological activities encompass anti-inflammatory,antioxidant...
关键词：MAGNOLOL Growth/differentiation factor-15 Activating transcription factor 4 CCAAT enhancer binding proteinγ ENHANCER Metabolic disorder 
Fabrication of Ce-doped macroporous carbon fibers for efficient degradation of tetracycline by activating persulfate
《Journal of Rare Earths》2025年第3期480-489,I0003,共11页Chaohai Wang Taiyang Cao Zheng Lv Rongfu Peng Yanli Mao Jinhui zhang Xinfeng Zhu Junning Wang Ke Zhao Gangfu Song 
Project supported by the National Natural Science Foundation of China(22206080);the Natural Science Foundation of Jiangsu(SBK2022041070);the Science and Technology Project of Henan Province(232102321050,232102321035);the International Science,Innovators,Technology Cooperation Projects of Henan Province(232102521009)。
Metal-organic frameworks(MOFs)and their derivatives have gained significant attention in recent years for their ability to catalyze the advanced oxidation of persulfates.Cerium-doped MOFs,in particular,have shown prom...
关键词：CERIUM Metal-organic frameworks ELECTROSPINNING TETRACYCLINE PERSULFATE Rare earths 
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