Despite existing curative options like surgical removal,tissue destruction techniques,and liver transplantation for early-stage hepatocellular carcinoma(HCC),the rising incidence and mortality rates of this global hea...
Ministry of Science and Technology of China,Grant/Award Number:2022YFE0110200;Natural Science Foundation of Jilin Province,Grant/Award Number:20230101037JC;National Natural Science Foundation of China,Grant/Award Numbers:52203198,52025035。
Ultrasound-generated antigens combined with TLR7/8 agonists as adjuvants have demonstrated significant anti-tumor efficacy as an in-situ vaccine.However,the use of TLR7/8 agonists can cause severe inflammatory respons...
supported by Key Project at Central Government Level:the ability establishment of sustainable use for valuable Chinese medicine resources(2060302-2305-04);CAMS Innovation Fund for Medical Sciences(2021-1-I2M-031,2022-I2M-1-018,2022-I2M-2-002);Jilin Provincial Fiscal Construction Program for High-Tech Industries and Technologies(2022C041-5,20220401117YY);Hohhot Science and Technology Program(2021-Social-4)。
The study of tumor nanovaccines(NVs)has gained interest because they specifically recognize and eliminate tumor cells.However,the poor recognition and internalization by dendritic cells(DCs)and insufficient immunogeni...
The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-...
In the last few decades,the treatment strategy for locally advanced resectable gastric cancer(GC)has shifted to a multimodal approach,which potentially decreases recurrence risk and improves survival rates.Perioperati...
Surgery followed by adjuvant chemotherapy is the standard of care for selectedpatients with early‐stage or locally advanced non‐small cell lung cancer(NSCLC). However, many of these patients still experience postope...
Immune-checkpoint inhibitors are extensively used in cancer treatment and have transformed the therapeutic landscape by inducing durable responses. Immunotherapy with checkpoint inhibitors targeting programmed death 1...
supported by National Natural Science Foundation of China(nos.21874097 and 12075164);National Key Research Program of China(no.2018YFA0208800);Suzhou Administration of Science and Technology(no.sys2018021);Jiangsu Province’s Natural Science Foundation(no.SBK2020041529);Pre-Research Foundation of the Second Affiliated Hospital of Soochow University(no.SDFEYBS1906);the Scientific Research Program for Young Talents of China National Nuclear Corporation;A Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the support by the Youth Innovation Promotion Association,Chinese Academy of Sciences(no.2020010).
Engineering synthetic vaccines is promising for improving the efficacy of cancer immunotherapy.One of the major challenges in the development of vaccines is achieving controllable codelivery of antigen and adjuvant to...
This work was supported by the CAMS Innovation Fund for Medical Sciences(2017-I2M-1-005).
A recent study1 published in The New England Journal of Medicine by Kelly RJ presented interim results from a phase 3 clinical trial(CheckMate 577),a global,randomized,double-blind,interventional trial to evaluate a n...
There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and ...