This work was supported by the National institute of Arthritis and Musculoskeletal and Skin Diseases(NIAMS)of the NIH under Award Numbers R01 AR069562 and AR073156(to K.H.P.-M.).
Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion.Macrophage colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,...
financially supported by the National High-Tech Research and Development Program of China(863 Program)(No.2006AA10A201);National Natural Science Foundation(No.30472093)
A serials of novel 5-substituted benzyl-2,4-diamino pyrimidine derivatives have been synthesized and evaluated as inhibitors of c-Fms kinase by the standard MTT method.The results showed that compound 15,5-[3-methoxy...
This study was supported by the National Science Foundation of China( No 30070853 ) and the Science Foundation of Guangdong Province,China (No. 990422)
BACKGROUND: Recent research found abnormal expres- sion of the c-fms oncogene, which encodes the macro- phage colony-stimulating factor receptor (CSF-1R), in several human carcinomas including hepatocellular carcino- ...